U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF429 zinc finger protein 429 [ Homo sapiens (human) ]

Gene ID: 353088, updated on 5-Mar-2024

Summary

Official Symbol
ZNF429provided by HGNC
Official Full Name
zinc finger protein 429provided by HGNC
Primary source
HGNC:HGNC:20817
See related
Ensembl:ENSG00000197013 AllianceGenome:HGNC:20817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 2.7), ovary (RPKM 1.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF429 in Genome Data Viewer
Location:
19p12
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21505602..21540668)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21644168..21679216)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21688404..21723470)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372321 Neighboring gene MPRA-validated peak3411 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21643213-21643712 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21646023-21646921 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21657297-21657950 Neighboring gene long intergenic non-protein coding RNA 664 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21688185-21688787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21688788-21689389 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21694415-21695021 Neighboring gene BCL2 interacting protein 3 pseudogene 26 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21734180-21734961 Neighboring gene uncharacterized LOC124904670 Neighboring gene uncharacterized LOC101929007 Neighboring gene uncharacterized LOC105372323

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001415.4NP_001001415.2  zinc finger protein 429 isoform a

    See identical proteins and their annotated locations for NP_001001415.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC010615, BM981242, DA533537
    Consensus CDS
    CCDS42537.1
    UniProtKB/Swiss-Prot
    A6NLV7, Q86V71, Q9BZE6
    Related
    ENSP00000351280.3, ENST00000358491.9
    Conserved Domains (5) summary
    smart00349
    Location:463
    KRAB; krueppel associated box
    COG5048
    Location:229624
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:427447
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:443
    KRAB; KRAB box
    pfam13465
    Location:467492
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001346912.2NP_001333841.1  zinc finger protein 429 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC010615
  3. NM_001346913.2NP_001333842.1  zinc finger protein 429 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 4 and 5, encodes isoform c.
    Source sequence(s)
    AC010615
  4. NM_001346914.2NP_001333843.1  zinc finger protein 429 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 3 and 5, encodes isoform c.
    Source sequence(s)
    AC010615
  5. NM_001346915.2NP_001333844.1  zinc finger protein 429 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 3 and 4, encodes isoform c.
    Source sequence(s)
    AC010615
  6. NM_001346916.2NP_001333845.1  zinc finger protein 429 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC010615

RNA

  1. NR_144522.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615, KC877715
  2. NR_144523.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615, KC877715
  3. NR_144524.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615, KC877715
  4. NR_144525.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615
    Related
    ENST00000598747.1
  5. NR_144526.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC010615
    Related
    ENST00000597556.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    21505602..21540668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438765.1XP_047294721.1  zinc finger protein 429 isoform X1

  2. XM_017026748.3XP_016882237.1  zinc finger protein 429 isoform X1

  3. XM_017026752.2XP_016882241.1  zinc finger protein 429 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    21644168..21679216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320855.1XP_054176830.1  zinc finger protein 429 isoform X1

  2. XM_054320857.1XP_054176832.1  zinc finger protein 429 isoform X1

  3. XM_054320856.1XP_054176831.1  zinc finger protein 429 isoform X1

  4. XM_054320858.1XP_054176833.1  zinc finger protein 429 isoform X2