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APP amyloid beta precursor protein [ Homo sapiens (human) ]

Gene ID: 351, updated on 27-Nov-2024

Summary

Official Symbol
APPprovided by HGNC
Official Full Name
amyloid beta precursor proteinprovided by HGNC
Primary source
HGNC:HGNC:620
See related
Ensembl:ENSG00000142192 MIM:104760; AllianceGenome:HGNC:620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP
Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in brain (RPKM 395.2), kidney (RPKM 282.2) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See APP in Genome Data Viewer
Location:
21q21.3
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (25880550..26171128, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (24238622..24529258, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (27252861..27543446, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372757 Neighboring gene uncharacterized LOC105372756 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27290380-27290953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27290954-27291526 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:27326978-27328177 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27333032-27333727 Neighboring gene RNA, U6 small nuclear 123, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27360167-27360668 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27369694-27370507 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27370508-27371320 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27395669-27396168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27451148-27451673 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:27452711-27453576 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27453577-27454444 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr21:27454445-27455310 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:27456082-27456619 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr21:27479739-27480384 Neighboring gene uncharacterized LOC124900466 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr21:27511930-27513129 Neighboring gene NANOG hESC enhancer GRCh37_chr21:27521254-27521823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13235 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:27542299-27542823 Neighboring gene APP divergent transcript Neighboring gene RNA, U6 small nuclear 926, pseudogene Neighboring gene myristoylated alanine rich protein kinase C substrate pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced upregulation of APP protein production involves JNK MAPK signaling pathway in human cells PubMed
env Transgenic (tg) mice overexpressing both human amyloid precursor proteins and HIV-1 gp120 at moderate levels show significantly less neuronal loss, synapto-dendritic degeneration, and gliosis than singly tg mice expressing gp120 alone PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 Env is identified to have a physical interaction with amyloid beta (A4) precursor protein (APP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Envelope transmembrane glycoprotein gp41 env A putative immunosuppressive domain (amino acids 583-599) of HIV-1 gp41 downregulates the interleukin 1beta- (IL-1beta) induced elevation of the secreted form of APP (sAPP alpha) PubMed
Tat tat HIV-1 Tat increases secreted and intracellular levels of APP (Ab); increases are dependent upon Tat amino acids 31-61 and can be inhibited by caffeine PubMed
tat HIV-1 Tat recruits APP into lipid rafts to facilitate the processing of APP by beta-secretase, which leads to increased levels of ABeta42 in HIV-1 infected U-87 MG cells PubMed
tat HIV-1 Tat co-localizes with APP and promotes localization of APP to lipid rafts with flotillin-1 in HIV-1 infected U-87 MG cells PubMed
tat Immunoprecipitation assay demonstrates that HIV-1 Tat directly interacts with APP and the cysteine-rich domain (residues 21-37) of Tat is required to APP binding in U-87 MG cells PubMed
tat HIV-1 Tat treatment results in a 125% increase in soluble amyloid beta (Abeta) in brain cultures PubMed
tat Binding of HIV-1 Tat to LRP inhibits neuronal binding, uptake and degradation of physiological ligands for LRP, including alpha2-macroglobulin, apolipoprotein E4, amyloid precursor and amyloid beta-protein PubMed
retropepsin gag-pol HIV-1 protease cleaves amyloid protein precursor at amino acid sites 200-201, 229-230, and 535-536 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables G protein-coupled receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables PTB domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RAGE receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables acetylcholine receptor activator activity TAS
Traceable Author Statement
more info
PubMed 
enables acetylcholine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables amylin binding TAS
Traceable Author Statement
more info
PubMed 
enables apolipoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chemoattractant activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables chromatin binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables heparan sulfate binding TAS
Traceable Author Statement
more info
PubMed 
enables heparan sulfate proteoglycan binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables insulin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables integrin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables low-density lipoprotein particle receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in NMDA selective glutamate receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in adult locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in amyloid fibril formation EXP
Inferred from Experiment
more info
PubMed 
involved_in amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in antifungal humoral response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in associative learning IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in astrocyte activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in astrocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in astrocyte activation involved in immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axo-dendritic transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axon midline choice point recognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT involved_in chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in collateral sprouting in absence of injury ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cytosolic mRNA polyadenylation IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendrite development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in endocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in extracellular matrix organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in forebrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular copper ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoprotein metabolic process IC
Inferred by Curator
more info
PubMed 
involved_in locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in low-density lipoprotein particle mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mating behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microglia development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in microglial cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microglial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in modulation of excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of blood circulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of gene expression TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of miRNA transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of presynapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein localization to nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron cellular homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuron projection maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron remodeling ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_positive_effect phospholipase D-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of G protein-coupled receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of T cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Toll signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of amyloid fibril formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of amyloid precursor protein catabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of cAMP/PKA signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of chemokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of endothelin production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of excitatory postsynaptic potential IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of gene expression, epigenetic IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of glycolytic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-6 production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of membrane protein ectodomain proteolysis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of monocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of monocyte chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of nitric oxide biosynthetic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein import IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of superoxide anion generation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of type II interferon production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein homooligomerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in protein tetramerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein tetramerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in protein trimerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein trimerization IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in regulation of Wnt signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in regulation of amyloid fibril formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of regulation of amyloid-beta clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of dendritic spine maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of long-term neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of multicellular organism growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neurotransmitter uptake IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of presynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of presynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of spontaneous synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of synapse structure or activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of toll-like receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in response to auditory stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to interleukin-1 ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 
involved_in response to yeast IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in smooth endoplasmic reticulum calcium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in suckling behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synaptic assembly at neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
involved_in visual learning ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in Golgi-associated vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of amyloid-beta complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of amyloid-beta complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of amyloid-beta complex TAS
Traceable Author Statement
more info
PubMed 
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
 
located_in axon ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with cell body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell surface NAS
Non-traceable Author Statement
more info
PubMed 
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
NOT colocalizes_with dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
NOT colocalizes_with dendrite membrane IDA
Inferred from Direct Assay
more info
PubMed 
NOT colocalizes_with dendrite membrane TAS
Traceable Author Statement
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome lumen TAS
Traceable Author Statement
more info
PubMed 
located_in endosome to plasma membrane transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 
part_of high-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of high-density lipoprotein particle IPI
Inferred from Physical Interaction
more info
PubMed 
part_of intermediate-density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of intermediate-density lipoprotein particle IPI
Inferred from Physical Interaction
more info
PubMed 
part_of lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of low-density lipoprotein particle IPI
Inferred from Physical Interaction
more info
PubMed 
colocalizes_with lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
colocalizes_with postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in smooth endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in spindle midzone IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
NOT colocalizes_with synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in trans-Golgi network membrane TAS
Traceable Author Statement
more info
 
part_of very-low-density lipoprotein particle IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
amyloid-beta precursor protein
Names
alzheimer disease amyloid A4 protein homolog
alzheimer disease amyloid protein
amyloid beta (A4) precursor protein
amyloid beta A4 protein
amyloid precursor protein
beta-amyloid peptide
beta-amyloid peptide(1-40)
beta-amyloid peptide(1-42)
beta-amyloid precursor protein
cerebral vascular amyloid peptide
peptidase nexin-II
protease nexin-II
testicular tissue protein Li 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007376.2 RefSeqGene

    Range
    5359..295579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000484.4NP_000475.1  amyloid-beta precursor protein isoform a precursor

    See identical proteins and their annotated locations for NP_000475.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as PreA4 770).
    Source sequence(s)
    AK312326, BC065529, BI559391, BM876312
    Consensus CDS
    CCDS13576.1
    UniProtKB/Swiss-Prot
    B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P05067, P09000, P78438, Q13764, Q13778, Q13793, Q16011, Q16014, Q16019, Q16020, Q6GSC0, Q8WZ99, Q9BT38, Q9UC33, Q9UCA9, Q9UCB6, Q9UCC8, Q9UCD1, Q9UQ58
    UniProtKB/TrEMBL
    A0A140VJC8, A0A218KGR2
    Related
    ENSP00000284981.4, ENST00000346798.8
    Conserved Domains (5) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294341
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:677713
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:716766
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
  2. NM_001136016.3NP_001129488.1  amyloid-beta precursor protein isoform d

    See identical proteins and their annotated locations for NP_001129488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus and lacks an internal segment compared to isoform a.
    Source sequence(s)
    AK295621, AK311717, BM876312, Y00264
    Consensus CDS
    CCDS56212.1
    UniProtKB/TrEMBL
    A0A218KGR2
    Related
    ENSP00000387483.2, ENST00000440126.7
    Conserved Domains (7) summary
    smart00006
    Location:19183
    A4_EXTRA; amyloid A4
    pfam00014
    Location:289337
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:26126
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:651689
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:692742
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:128183
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:342524
    APP_E2; E2 domain of amyloid precursor protein
  3. NM_001136129.3NP_001129601.1  amyloid-beta precursor protein isoform e precursor

    See identical proteins and their annotated locations for NP_001129601.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AF282245, BC065529, BI559391, BM876312
    Consensus CDS
    CCDS46638.1
    UniProtKB/TrEMBL
    B4DQM1
    Related
    ENSP00000346129.3, ENST00000354192.7
    Conserved Domains (4) summary
    pfam03494
    Location:544582
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:585635
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:235417
    APP_E2; E2 domain of amyloid precursor protein
    cl26273
    Location:19132
    APP_N; Amyloid A4 N-terminal heparin-binding
  4. NM_001136130.3NP_001129602.1  amyloid-beta precursor protein isoform f precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (f) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK294534, BC065523, BC065529, BI559391, BM876312
    Consensus CDS
    CCDS46639.1
    UniProtKB/TrEMBL
    B4DGD0, E9PG40
    Related
    ENSP00000398879.2, ENST00000439274.6
    Conserved Domains (6) summary
    pfam00014
    Location:238286
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:1975
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:619657
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:660710
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:77132
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:310492
    APP_E2; E2 domain of amyloid precursor protein
  5. NM_001136131.3NP_001129603.1  amyloid-beta precursor protein isoform g

    See identical proteins and their annotated locations for NP_001129603.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate in-frame exons compared to variant 1. The resulting isoform (g) is shorter at the N-terminus and lacks an internal segment compared to isoform a.
    Source sequence(s)
    AK296229, BM876312, Y00264
    Consensus CDS
    CCDS56211.1
    UniProtKB/TrEMBL
    A0A0A0MRG2, B4DJT9
    Related
    ENSP00000352760.4, ENST00000359726.7
    Conserved Domains (4) summary
    smart00006
    Location:1153
    A4_EXTRA; amyloid A4
    pfam03494
    Location:565603
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:606656
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:256438
    APP_E2; E2 domain of amyloid precursor protein
  6. NM_001204301.2NP_001191230.1  amyloid-beta precursor protein isoform h precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (h, also known as L-APP752) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
    Source sequence(s)
    AK294534, AK312326, BI559391, BM876312, Y00264
    Consensus CDS
    CCDS56213.1
    UniProtKB/TrEMBL
    A0A218KGR2
    Related
    ENSP00000351796.3, ENST00000358918.7
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:657695
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:698748
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
  7. NM_001204302.2NP_001191231.1  amyloid-beta precursor protein isoform i precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (i, also known as L-APP733) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
    Source sequence(s)
    BI559391, BM876312, X06989, Y00264
    UniProtKB/TrEMBL
    A0A218KGR2
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:638676
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:679729
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:347529
    APP_E2; E2 domain of amyloid precursor protein
  8. NM_001204303.2NP_001191232.1  amyloid-beta precursor protein isoform j precursor

    See identical proteins and their annotated locations for NP_001191232.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (j, also known as L-APP677) has the same N- and C-termini but is shorter compared to isoform a. No full-length transcript is available for this transcript; however, it is supported by PMID:1429732 and other publications.
    Source sequence(s)
    BI559391, BM876312, Y00264
    UniProtKB/TrEMBL
    B4DQM1
    Conserved Domains (3) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12925
    Location:291473
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:600674
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
  9. NM_001385253.1NP_001372182.1  amyloid-beta precursor protein isoform k precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (k) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AP001439, AP001440, AP001441, AP001442, AP001443, KC877827
    UniProtKB/TrEMBL
    B4DQM1
    Conserved Domains (3) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12925
    Location:310492
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:637711
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins
  10. NM_201413.3NP_958816.1  amyloid-beta precursor protein isoform b precursor

    See identical proteins and their annotated locations for NP_958816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b, also known as PreA4 751) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC065529, BI559391, BM876312
    Consensus CDS
    CCDS33523.1
    UniProtKB/TrEMBL
    A0A218KGR2
    Related
    ENSP00000350578.3, ENST00000357903.7
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:656694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:697747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:347529
    APP_E2; E2 domain of amyloid precursor protein
  11. NM_201414.3NP_958817.1  amyloid-beta precursor protein isoform c precursor

    See identical proteins and their annotated locations for NP_958817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (c, also known as PreA4 695) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BI559391, BM876312, Y00264
    Consensus CDS
    CCDS13577.1
    UniProtKB/TrEMBL
    B4DQM1
    Related
    ENSP00000345463.5, ENST00000348990.9
    Conserved Domains (3) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12925
    Location:291473
    APP_E2; E2 domain of amyloid precursor protein
    cl41775
    Location:618692
    JMTM_Notch_APP; juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    25880550..26171128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    24238622..24529258 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)