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App amyloid beta (A4) precursor protein [ Mus musculus (house mouse) ]

Gene ID: 11820, updated on 18-Sep-2018

Summary

Official Symbol
Appprovided by MGI
Official Full Name
amyloid beta (A4) precursor proteinprovided by MGI
Primary source
MGI:MGI:88059
See related
Ensembl:ENSMUSG00000022892
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik
Expression
Ubiquitous expression in cerebellum adult (RPKM 142.7), lung adult (RPKM 135.8) and 25 other tissues See more
Orthologs

Genomic context

See App in Genome Data Viewer
Location:
16 C3.3; 16 46.92 cM
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (84952666..85173952, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (84954688..85173948, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene junction adhesion molecule 2 Neighboring gene predicted gene, 46557 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F Neighboring gene GA repeat binding protein, alpha Neighboring gene predicted gene 10791 Neighboring gene predicted gene, 41482 Neighboring gene predicted gene, 41483

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (31)  1 citation
  • Endonuclease-mediated (2) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
PTB domain binding ISO
Inferred from Sequence Orthology
more info
 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
heparin binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
peptidase activator activity ISO
Inferred from Sequence Orthology
more info
 
peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
astrocyte activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
axo-dendritic transport IGI
Inferred from Genetic Interaction
more info
PubMed 
axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
axon midline choice point recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular copper ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular process ISO
Inferred from Sequence Orthology
more info
 
cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
cellular response to norepinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cognition IDA
Inferred from Direct Assay
more info
PubMed 
collateral sprouting in absence of injury IGI
Inferred from Genetic Interaction
more info
PubMed 
dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ionotropic glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning ISO
Inferred from Sequence Orthology
more info
 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
long-term synaptic potentiation TAS
Traceable Author Statement
more info
PubMed 
mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
mating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
memory TAS
Traceable Author Statement
more info
PubMed 
microglia development ISO
Inferred from Sequence Orthology
more info
 
modulation of age-related behavioral decline ISO
Inferred from Sequence Orthology
more info
 
modulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection maintenance ISO
Inferred from Sequence Orthology
more info
 
neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
protein homooligomerization ISO
Inferred from Sequence Orthology
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epidermal growth factor-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of spontaneous synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
smooth endoplasmic reticulum calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
suckling behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
synapse organization ISO
Inferred from Sequence Orthology
more info
 
synaptic growth at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
axon IDA
Inferred from Direct Assay
more info
PubMed 
axon ISO
Inferred from Sequence Orthology
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
ciliary rootlet IDA
Inferred from Direct Assay
more info
PubMed 
clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
early endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
growth cone filopodium ISO
Inferred from Sequence Orthology
more info
 
growth cone lamellipodium ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
main axon ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
amyloid-beta A4 protein; amyloid beta A4 protein
Names
alzheimer disease amyloid A4 protein homolog
amyloid precursor protein
amyloid-beta precursor protein
amyloidogenic glycoprotein
appican
beta-amyloid precursor protein
protease nexin II

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198823.1NP_001185752.1  amyloid-beta A4 protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK128971, AK159718, BC070409, BP753972
    UniProtKB/Swiss-Prot
    P12023
    UniProtKB/TrEMBL
    Q3TWF3, Q6GR78
    Related
    ENSMUSP00000154061.1, ENSMUST00000227723.1
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:675713
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:716766
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
  2. NM_001198824.1NP_001185753.1  amyloid-beta A4 protein isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK133639, BC070409, BP753972
    UniProtKB/TrEMBL
    Q6GR78
    Related
    ENSMUSP00000154389.1, ENSMUST00000226232.1
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:656694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:697747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:347529
    APP_E2; E2 domain of amyloid precursor protein
  3. NM_001198825.1NP_001185754.1  amyloid-beta A4 protein isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK133639, BC070409, BP753972
    UniProtKB/TrEMBL
    Q6GR78
    Related
    ENSMUSP00000153907.1, ENSMUST00000227021.1
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:638676
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:679729
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:347529
    APP_E2; E2 domain of amyloid precursor protein
  4. NM_001198826.1NP_001185755.1  amyloid-beta A4 protein isoform 6 precursor

    See identical proteins and their annotated locations for NP_001185755.1

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK159718, BC070409, BP753972
    UniProtKB/TrEMBL
    Q3TWF3, Q6GR78
    Related
    ENSMUSP00000154097.1, ENSMUST00000226801.1
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:657695
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:698748
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
  5. NM_007471.3NP_031497.2  amyloid-beta A4 protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_031497.2

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, BC070409, BP753972
    Consensus CDS
    CCDS28285.1
    UniProtKB/TrEMBL
    Q6GR78
    Related
    ENSMUSP00000005406.10, ENSMUST00000005406.11
    Conserved Domains (6) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:600638
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:641691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:291473
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    84952666..85173952 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522873.2XP_006522936.1  amyloid beta A4 protein isoform X1

    Conserved Domains (6) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:582620
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:623673
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:291473
    APP_E2; E2 domain of amyloid precursor protein
  2. XM_006522874.1XP_006522937.1  amyloid beta A4 protein isoform X2

    Related
    ENSMUSP00000154401.1, ENSMUST00000227737.1
    Conserved Domains (5) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
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