App amyloid beta precursor protein [ Mus musculus (house mouse) ]

Gene ID: 11820, updated on 5-Nov-2024

Summary

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Official Symbol: Appprovided by MGI
Official Full Name: amyloid beta precursor proteinprovided by MGI
Primary source: MGI:MGI:88059
See related: Ensembl:ENSMUSG00000022892 AllianceGenome:MGI:88059
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik
Summary: Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and protein kinase binding activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including intracellular monoatomic cation homeostasis; nervous system development; and regulation of protein metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is active in cell surface; intracellular vesicle; and presynaptic active zone. Is expressed in several structures, including alimentary system; central nervous system; metanephros; peripheral nervous system; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease (multiple); cognitive disorder; traumatic brain injury; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in cerebellum adult (RPKM 142.7), lung adult (RPKM 135.8) and 25 other tissues See more
Orthologs: human all
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Genomic context

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See App in Genome Data Viewer

Location:: 16 C3.3; 16 46.92 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (84751236..84972187, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (84952666..85175255, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vascular dysfunction occurs prior to the onset of amyloid pathology and Abeta plaque deposits colocalize with endothelial cells in the hippocampus of female APPswe/PSEN1dE9 mice.
Title: Vascular dysfunction occurs prior to the onset of amyloid pathology and Aβ plaque deposits colocalize with endothelial cells in the hippocampus of female APPswe/PSEN1dE9 mice.
Brain regions differences in amyloid-beta and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease.
Title: Brain regions differences in amyloid-β and gene expression in early APP/PS1 mice and identification of Npas4 as a key molecule in Alzheimer's disease.
The Potential Related Genes and Mechanisms Involved in Improving the Treadmill Exercise Ability of APP/PS1 Mice.
Title: The Potential Related Genes and Mechanisms Involved in Improving the Treadmill Exercise Ability of APP/PS1 Mice.
Decreased extrasynaptic delta-GABAA receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.
Title: Decreased extrasynaptic δ-GABA(A) receptors in PNN-associated parvalbumin interneurons correlates with anxiety in APP and tau mouse models of Alzheimer's disease.
A Potential Role for the Amyloid Precursor Protein in the Regulation of Interferon Signaling, Cholesterol Homeostasis, and Tau Phosphorylation in Niemann-Pick Disease Type C.
Title: A Potential Role for the Amyloid Precursor Protein in the Regulation of Interferon Signaling, Cholesterol Homeostasis, and Tau Phosphorylation in Niemann-Pick Disease Type C.
Monocytes release cystatin F dimer to associate with Abeta and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease.
Title: Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease.
Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Abeta burden in early Alzheimer's disease models.
Title: Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer's disease models.
Oligodendrocytes produce amyloid-beta and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
Title: Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
Title: Selective suppression of oligodendrocyte-derived amyloid beta rescues neuronal dysfunction in Alzheimer's disease.
beta-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models of Alzheimer's Disease.
Title: β-amyloid monomer scavenging by an anticalin protein prevents neuronal hyperactivity in mouse models of Alzheimer's Disease.

Submit: New GeneRIF Correction See all GeneRIFs (813)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (15) 1 citation
Targeted (40) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:185158 (e-PCR)
- UniSTS:155414

RH124994 (e-PCR)
- UniSTS:161816

RH125538 (e-PCR)
- UniSTS:162353

App (e-PCR), detects polymorphism
- UniSTS:141114

App (e-PCR), detects polymorphism
- UniSTS:536418

App (e-PCR), detects polymorphism
- UniSTS:536419

App (e-PCR), detects polymorphism
- UniSTS:536420

RH139209 (e-PCR)
- UniSTS:221295

RH125986 (e-PCR)
- UniSTS:162698

APP (e-PCR)
- UniSTS:266418

App (e-PCR), detects polymorphism
- UniSTS:259038

NoName (e-PCR)
- UniSTS:237537

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables PTB domain binding	IEA Inferred from Electronic Annotation more info
enables PTB domain binding	ISO Inferred from Sequence Orthology more info
enables RAGE receptor binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables acetylcholine receptor binding	ISO Inferred from Sequence Orthology more info
enables apolipoprotein binding	ISO Inferred from Sequence Orthology more info
enables chemoattractant activity	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ephrin receptor binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info	PubMed
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables low-density lipoprotein particle receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptidase activator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IDA Inferred from Direct Assay more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activator activity	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor activator activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transition metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in antibacterial humoral response	ISO Inferred from Sequence Orthology more info
involved_in antifungal humoral response	ISO Inferred from Sequence Orthology more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
involved_in associative learning	ISO Inferred from Sequence Orthology more info
involved_in astrocyte activation	ISO Inferred from Sequence Orthology more info
involved_in astrocyte activation involved in immune response	IEA Inferred from Electronic Annotation more info
involved_in astrocyte activation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within axo-dendritic transport	IGI Inferred from Genetic Interaction more info	PubMed
NOT acts_upstream_of_or_within axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axo-dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axonogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to norepinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cholesterol metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cholesterol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cognition	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within collateral sprouting in absence of injury	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cytosolic mRNA polyadenylation	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dendrite development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within extracellular matrix organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular copper ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within intracellular copper ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning	ISO Inferred from Sequence Orthology more info
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in long-term synaptic potentiation	TAS Traceable Author Statement more info	PubMed
involved_in low-density lipoprotein particle mediated signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mating behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in memory	TAS Traceable Author Statement more info	PubMed
involved_in microglia development	IEA Inferred from Electronic Annotation more info
involved_in microglia development	ISO Inferred from Sequence Orthology more info
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in modulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood circulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of blood circulation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of peptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of presynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuromuscular process controlling balance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron cellular homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron projection development	IDA Inferred from Direct Assay more info	PubMed
involved_in neuron projection maintenance	IEA Inferred from Electronic Annotation more info
involved_in neuron projection maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_positive_effect phospholipase D-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor internalization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Toll signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid fibril formation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of amyloid precursor protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelin production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of endothelin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression, epigenetic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of membrane protein ectodomain proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase A signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of superoxide anion generation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein trimerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of amyloid-beta clearance	ISO Inferred from Sequence Orthology more info
involved_in regulation of dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
involved_in regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of long-term neuronal synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of long-term neuronal synaptic plasticity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurotransmitter uptake	ISO Inferred from Sequence Orthology more info
involved_in regulation of peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein binding	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in regulation of spontaneous synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in regulation of spontaneous synaptic transmission	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of synapse structure or activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to interleukin-1	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to yeast	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smooth endoplasmic reticulum calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within suckling behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in COPII-coated ER to Golgi transport vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi-associated vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of amyloid-beta complex	ISO Inferred from Sequence Orthology more info
located_in apical part of cell	IDA Inferred from Direct Assay more info	PubMed
located_in astrocyte projection	ISO Inferred from Sequence Orthology more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IMP Inferred from Mutant Phenotype more info	PubMed
located_in axon	ISO Inferred from Sequence Orthology more info
colocalizes_with cell body	ISO Inferred from Sequence Orthology more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary rootlet	IDA Inferred from Direct Assay more info	PubMed
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic shaft	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in endosome to plasma membrane transport vesicle	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in growth cone	IEA Inferred from Electronic Annotation more info
located_in growth cone	ISO Inferred from Sequence Orthology more info
located_in growth cone filopodium	ISO Inferred from Sequence Orthology more info
located_in growth cone lamellipodium	ISO Inferred from Sequence Orthology more info
part_of high-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of intermediate-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
is_active_in intracellular vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of lipoprotein particle	ISO Inferred from Sequence Orthology more info
part_of low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info
colocalizes_with lysosome	ISO Inferred from Sequence Orthology more info
located_in main axon	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
is_active_in membrane raft	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with neuron projection	ISO Inferred from Sequence Orthology more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope lumen	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with postsynapse	ISO Inferred from Sequence Orthology more info
colocalizes_with presynapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone	IEP Inferred from Expression Pattern more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in smooth endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in spindle midzone	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
part_of very-low-density lipoprotein particle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: amyloid-beta precursor protein

Names: alzheimer disease amyloid A4 protein homolog; alzheimer disease amyloid protein; amyloid beta (A4) precursor protein; amyloid beta A4 protein; amyloid precursor protein; amyloidogenic glycoprotein; appican; beta-amyloid precursor protein; protease nexin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001198823.1 → NP_001185752.1 amyloid-beta precursor protein isoform 1 precursor

See identical proteins and their annotated locations for NP_001185752.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AK128971, AK159718, BC070409, BP753972

Consensus CDS

CCDS88958.1

UniProtKB/Swiss-Prot

P12023, P97487, P97942, Q99K32

UniProtKB/TrEMBL

Q53ZT3

Related

ENSMUSP00000154061.2, ENSMUST00000227723.2

Conserved Domains (5) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 341

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam03494
Location:677 → 713

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:716 → 766

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12925
Location:366 → 548

APP_E2; E2 domain of amyloid precursor protein
NM_001198824.1 → NP_001185753.1 amyloid-beta precursor protein isoform 3 precursor

Status: VALIDATED

Description

Transcript Variant: Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK128971, AK133639, BC070409, BP753972

Consensus CDS

CCDS88956.1

UniProtKB/TrEMBL

A0A2I3BQZ9, Q53ZT3

Related

ENSMUSP00000154389.2, ENSMUST00000226232.2

Conserved Domains (7) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 342

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:656 → 694

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:697 → 747

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:347 → 529

APP_E2; E2 domain of amyloid precursor protein
NM_001198825.1 → NP_001185754.1 amyloid-beta precursor protein isoform 5 precursor

Status: VALIDATED

Description

Transcript Variant: Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK128971, AK133639, BC070409, BP753972

Consensus CDS

CCDS88955.1

UniProtKB/TrEMBL

A0A2I3BPT1, Q3TXI9

Related

ENSMUSP00000153907.2, ENSMUST00000227021.2

Conserved Domains (7) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 342

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:638 → 676

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:679 → 729

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:347 → 529

APP_E2; E2 domain of amyloid precursor protein
NM_001198826.1 → NP_001185755.1 amyloid-beta precursor protein isoform 6 precursor

See identical proteins and their annotated locations for NP_001185755.1

Status: VALIDATED

Description

Transcript Variant: Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK128971, AK159718, BC070409, BP753972

Consensus CDS

CCDS88957.1

UniProtKB/TrEMBL

Q3TWF3, Q3TXI9

Related

ENSMUSP00000154097.2, ENSMUST00000226801.2

Conserved Domains (7) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 342

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:657 → 695

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:698 → 748

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:366 → 548

APP_E2; E2 domain of amyloid precursor protein
NM_007471.3 → NP_031497.2 amyloid-beta precursor protein isoform 2 precursor

See identical proteins and their annotated locations for NP_031497.2

Status: VALIDATED

Description

Transcript Variant: Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AK128971, BC070409, BP753972

Consensus CDS

CCDS28285.1

UniProtKB/TrEMBL

Q53ZT3, Q6GR78

Related

ENSMUSP00000005406.11, ENSMUST00000005406.12

Conserved Domains (6) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam02177
Location:31 → 131

APP_N; Amyloid A4 N-terminal heparin-binding

pfam03494
Location:600 → 638

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:641 → 691

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12924
Location:133 → 188

APP_Cu_bd; Copper-binding of amyloid precursor, CuBD

pfam12925
Location:291 → 473

APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000082.7 Reference GRCm39 C57BL/6J

Range

84751236..84972187 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006522873.4 → XP_006522936.1 amyloid-beta precursor protein isoform X1

UniProtKB/TrEMBL

Q53ZT3

Conserved Domains (4) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam03494
Location:584 → 620

Beta-APP; Beta-amyloid peptide (beta-APP)

pfam10515
Location:623 → 673

APP_amyloid; beta-amyloid precursor protein C-terminus

pfam12925
Location:291 → 473

APP_E2; E2 domain of amyloid precursor protein
XM_006522874.3 → XP_006522937.1 amyloid-beta precursor protein isoform X2

UniProtKB/TrEMBL

A0A2I3BR03

Related

ENSMUSP00000154401.2, ENSMUST00000227737.2

Conserved Domains (3) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam00014
Location:294 → 341

Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain

pfam12925
Location:366 → 548

APP_E2; E2 domain of amyloid precursor protein
XM_036159749.1 → XP_036015642.1 amyloid-beta precursor protein isoform X3

Conserved Domains (2) summary

smart00006
Location:24 → 188

A4_EXTRA; amyloid A4

pfam12925
Location:291 → 420

APP_E2; E2 domain of amyloid precursor protein