U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

App amyloid beta (A4) precursor protein [ Mus musculus (house mouse) ]

Gene ID: 11820, updated on 31-Jan-2023

Summary

Official Symbol
Appprovided by MGI
Official Full Name
amyloid beta (A4) precursor proteinprovided by MGI
Primary source
MGI:MGI:88059
See related
Ensembl:ENSMUSG00000022892 AllianceGenome:MGI:88059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik
Summary
Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; low-density lipoprotein particle receptor binding activity; and signaling receptor activator activity. Involved in negative regulation of blood circulation; positive regulation of endothelin production; and positive regulation of tumor necrosis factor production. Acts upstream of or within several processes, including cellular metal ion homeostasis; nervous system development; and regulation of cellular protein metabolic process. Located in several cellular components, including cytoplasmic vesicle; cytoskeleton; and neuromuscular junction. Is integral component of membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; neurogenic placode; and sensory organ. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in APP-related cerebral amyloid angiopathy; Alzheimer's disease; Alzheimer's disease 1; cognitive disorder; and visual epilepsy. Orthologous to human APP (amyloid beta precursor protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 142.7), lung adult (RPKM 135.8) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See App in Genome Data Viewer
Location:
16 C3.3; 16 46.92 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (84751236..84972187, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (84952666..85175255, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene junction adhesion molecule 2 Neighboring gene predicted gene, 46557 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F Neighboring gene GA repeat binding protein, alpha Neighboring gene predicted gene 10791 Neighboring gene predicted gene, 49227 Neighboring gene predicted gene, 41482 Neighboring gene predicted gene, 41483

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables PTB domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RAGE receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables acetylcholine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables heparan sulfate proteoglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables insulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables ion binding ISO
Inferred from Sequence Orthology
more info
 
enables low-density lipoprotein particle receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables signaling receptor activator activity ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antifungal humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in associative learning ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte activation ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte activation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within axo-dendritic transport IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT acts_upstream_of_or_within axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within axon midline choice point recognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to norepinephrine stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cholesterol metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cognition IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within collateral sprouting in absence of injury IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendrite development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular copper ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ionotropic glutamate receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in long-term synaptic potentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within mRNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within mating behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in memory ISO
Inferred from Sequence Orthology
more info
 
involved_in memory TAS
Traceable Author Statement
more info
PubMed 
involved_in microglia development ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of blood circulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of blood circulation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendritic spine maintenance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-term synaptic potentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of long-term synaptic potentiation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron projection maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G protein-coupled receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NIK/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelin production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of endothelin production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of excitatory postsynaptic potential ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic depression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of long-term synaptic depression NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of long-term synaptic potentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oxidative stress-induced neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tau-protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein tetramerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein trimerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of acetylcholine-gated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of regulation of amyloid-beta clearance ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of dendritic spine maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of epidermal growth factor-activated receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of long-term neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of presynapse assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein binding IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of spontaneous synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of synapse structure or activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to yeast ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within smooth endoplasmic reticulum calcium ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within suckling behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in synapse organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within synaptic assembly at neuromuscular junction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Golgi-associated vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of amyloid-beta complex ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in astrocyte projection ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
PubMed 
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endosome to plasma membrane transport vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space NAS
Non-traceable Author Statement
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone filopodium ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone lamellipodium ISO
Inferred from Sequence Orthology
more info
 
part_of high-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of intermediate-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
part_of low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in main axon ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuronal dense core vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
colocalizes_with postsynapse ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic active zone IEP
Inferred from Expression Pattern
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in spindle midzone IDA
Inferred from Direct Assay
more info
PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of very-low-density lipoprotein particle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
amyloid-beta precursor protein; amyloid-beta A4 protein
Names
alzheimer disease amyloid A4 protein homolog
alzheimer disease amyloid protein
amyloid beta A4 protein
amyloid precursor protein
amyloidogenic glycoprotein
appican
beta-amyloid precursor protein
protease nexin II

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198823.1NP_001185752.1  amyloid-beta precursor protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001185752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK128971, AK159718, BC070409, BP753972
    Consensus CDS
    CCDS88958.1
    UniProtKB/Swiss-Prot
    P12023, Q99K32
    UniProtKB/TrEMBL
    Q3TWF3, Q6GR78
    Related
    ENSMUSP00000154061.2, ENSMUST00000227723.2
    Conserved Domains (5) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294341
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam03494
    Location:677713
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:716766
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
  2. NM_001198824.1NP_001185753.1  amyloid-beta precursor protein isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK133639, BC070409, BP753972
    Consensus CDS
    CCDS88956.1
    UniProtKB/TrEMBL
    A0A2I3BQZ9, Q6GR78
    Related
    ENSMUSP00000154389.2, ENSMUST00000226232.2
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:656694
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:697747
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:347529
    APP_E2; E2 domain of amyloid precursor protein
  3. NM_001198825.1NP_001185754.1  amyloid-beta precursor protein isoform 5 precursor

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK133639, BC070409, BP753972
    Consensus CDS
    CCDS88955.1
    UniProtKB/TrEMBL
    A0A2I3BPT1, Q6GR78
    Related
    ENSMUSP00000153907.2, ENSMUST00000227021.2
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:638676
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:679729
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:347529
    APP_E2; E2 domain of amyloid precursor protein
  4. NM_001198826.1NP_001185755.1  amyloid-beta precursor protein isoform 6 precursor

    See identical proteins and their annotated locations for NP_001185755.1

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, AK159718, BC070409, BP753972
    Consensus CDS
    CCDS88957.1
    UniProtKB/TrEMBL
    Q3TWF3, Q6GR78
    Related
    ENSMUSP00000154097.2, ENSMUST00000226801.2
    Conserved Domains (7) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294342
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:657695
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:698748
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
  5. NM_007471.3NP_031497.2  amyloid-beta precursor protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_031497.2

    Status: VALIDATED

    Description
    Transcript Variant: Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK128971, BC070409, BP753972
    Consensus CDS
    CCDS28285.1
    UniProtKB/TrEMBL
    Q6GR78
    Related
    ENSMUSP00000005406.11, ENSMUST00000005406.12
    Conserved Domains (6) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam02177
    Location:31131
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:600638
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:641691
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:133188
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:291473
    APP_E2; E2 domain of amyloid precursor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    84751236..84972187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522873.4XP_006522936.1  amyloid-beta A4 protein isoform X1

    Conserved Domains (4) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam03494
    Location:584620
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:623673
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12925
    Location:291473
    APP_E2; E2 domain of amyloid precursor protein
  2. XM_006522874.3XP_006522937.1  amyloid-beta A4 protein isoform X2

    Related
    ENSMUSP00000154401.2, ENSMUST00000227737.2
    Conserved Domains (3) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam00014
    Location:294341
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam12925
    Location:366548
    APP_E2; E2 domain of amyloid precursor protein
  3. XM_036159749.1XP_036015642.1  amyloid-beta A4 protein isoform X3

    Conserved Domains (2) summary
    smart00006
    Location:24188
    A4_EXTRA; amyloid A4
    pfam12925
    Location:291420
    APP_E2; E2 domain of amyloid precursor protein