Format

Send to:

Choose Destination

ZNF774 zinc finger protein 774 [ Homo sapiens (human) ]

Gene ID: 342132, updated on 5-Jan-2022

Summary

Official Symbol
ZNF774provided by HGNC
Official Full Name
zinc finger protein 774provided by HGNC
Primary source
HGNC:HGNC:33108
See related
Ensembl:ENSG00000196391
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in colon (RPKM 1.2), brain (RPKM 0.9) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ZNF774 in Genome Data Viewer
Location:
15q26.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (90351439..90362847)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (90895516..90906079)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 736, pseudogene Neighboring gene GOLGA2 pseudogene 8 Neighboring gene GABA type A receptor associated protein like 3 pseudogene Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 4 Neighboring gene IQ motif containing GTPase activating protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of zinc finger protein 774 (ZNF774) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC75360

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004309.3NP_001004309.2  zinc finger protein 774

    See identical proteins and their annotated locations for NP_001004309.2

    Status: VALIDATED

    Source sequence(s)
    AC018946, BC067279, DA017564
    Consensus CDS
    CCDS32330.1
    UniProtKB/Swiss-Prot
    Q6NX45
    Related
    ENSP00000346348.3, ENST00000354377.8
    Conserved Domains (4) summary
    COG5048
    Location:152483
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:349369
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:291313
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:305328
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    90351439..90362847
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022128.2XP_016877617.1  zinc finger protein 774 isoform X1

  2. XM_017022127.1XP_016877616.1  zinc finger protein 774 isoform X1

  3. XM_017022129.1XP_016877618.1  zinc finger protein 774 isoform X1

RNA

  1. XR_001751249.2 RNA Sequence

Support Center