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Kcp kielin/chordin-like protein [ Mus musculus (house mouse) ]

Gene ID: 333088, updated on 18-Apr-2024

Summary

Official Symbol
Kcpprovided by MGI
Official Full Name
kielin/chordin-like proteinprovided by MGI
Primary source
MGI:MGI:2141640
See related
Ensembl:ENSMUSG00000059022 AllianceGenome:MGI:2141640
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crim2; Gm793; KCP-1; CRIM-2
Summary
Acts upstream of or within hematopoietic progenitor cell differentiation and positive regulation of BMP signaling pathway. Located in extracellular space. Orthologous to human KCP (kielin cysteine rich BMP regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 11.6), ovary adult (RPKM 5.1) and 16 other tissues See more
Orthologs
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Genomic context

Location:
6 A3.3; 6 12.36 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (29473161..29508006, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (29473162..29508003, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene filamin C, gamma Neighboring gene STARR-positive B cell enhancer mm9_chr6:29417613-29417914 Neighboring gene ATPase, H+ transporting, lysosomal V1 subunit F Neighboring gene sperm microtubule inner protein 1 Neighboring gene predicted gene, 26627 Neighboring gene STARR-positive B cell enhancer ABC_E3647 Neighboring gene STARR-seq mESC enhancer starr_15441 Neighboring gene interferon regulatory factor 5 Neighboring gene transportin 3 Neighboring gene STARR-seq mESC enhancer starr_15442 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559591-29559700 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:29559883-29560036 Neighboring gene STARR-seq mESC enhancer starr_15443 Neighboring gene STARR-seq mESC enhancer starr_15447 Neighboring gene STARR-positive B cell enhancer ABC_E6419 Neighboring gene STARR-seq mESC enhancer starr_15449 Neighboring gene predicted gene, 30896

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
kielin/chordin-like protein
Names
cysteine rich BMP regulator 2 (chordin like)
cysteine-rich BMP regulator 2
cysteine-rich motor neuron 2 protein
kielin/chordin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029985.4NP_001025156.3  kielin/chordin-like protein precursor

    See identical proteins and their annotated locations for NP_001025156.3

    Status: VALIDATED

    Source sequence(s)
    AC079276, BC059023
    Consensus CDS
    CCDS57415.1
    UniProtKB/Swiss-Prot
    E9QJU0, Q3U492, Q56NI8
    UniProtKB/TrEMBL
    E9QNB3
    Related
    ENSMUSP00000099135.4, ENSMUST00000101614.10
    Conserved Domains (5) summary
    pfam00093
    Location:136190
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:12141363
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:14891542
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:14071478
    C8; C8 domain
    cl17735
    Location:428484
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    29473161..29508006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241070.4XP_011239372.1  kielin/chordin-like protein isoform X8

    Conserved Domains (6) summary
    smart00214
    Location:12211278
    VWC; von Willebrand factor (vWF) type C domain
    pfam00093
    Location:166220
    VWC; von Willebrand factor type C domain
    cl17735
    Location:634690
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:12851432
    VWD; von Willebrand factor type D domain
    pfam03157
    Location:17571975
    Glutenin_hmw; High molecular weight glutenin subunit
    pfam08742
    Location:14821549
    C8; C8 domain
  2. XM_011241071.3XP_011239373.1  kielin/chordin-like protein isoform X1

    Conserved Domains (5) summary
    pfam00093
    Location:166220
    VWC; von Willebrand factor type C domain
    cl17735
    Location:458514
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:12851432
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:15601613
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:14821549
    C8; C8 domain
  3. XM_017321660.3XP_017177149.1  kielin/chordin-like protein isoform X2

    Conserved Domains (5) summary
    pfam00093
    Location:136190
    VWC; von Willebrand factor type C domain
    cl17735
    Location:428484
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:12551402
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:15301583
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:14521519
    C8; C8 domain
  4. XM_017321661.3XP_017177150.1  kielin/chordin-like protein isoform X4

    Conserved Domains (5) summary
    pfam00093
    Location:166220
    VWC; von Willebrand factor type C domain
    cl17735
    Location:458514
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:12431390
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:15181571
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:14401507
    C8; C8 domain
  5. XM_006505131.4XP_006505194.1  kielin/chordin-like protein isoform X3

    Conserved Domains (5) summary
    pfam00093
    Location:166220
    VWC; von Willebrand factor type C domain
    cl17735
    Location:458514
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:12441391
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:15191572
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:14411508
    C8; C8 domain
  6. XM_030255489.2XP_030111349.1  kielin/chordin-like protein isoform X6

    Conserved Domains (5) summary
    smart00214
    Location:845902
    VWC; von Willebrand factor (vWF) type C domain
    cl17735
    Location:82138
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:9091056
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:11841237
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:11061173
    C8; C8 domain
  7. XM_017321663.3XP_017177152.1  kielin/chordin-like protein isoform X5

    Conserved Domains (4) summary
    cl17735
    Location:277333
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:11041251
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:13791432
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:13011368
    C8; C8 domain
  8. XM_006505134.5XP_006505197.1  kielin/chordin-like protein isoform X7

    Conserved Domains (1) summary
    cl17735
    Location:166220
    VWC; von Willebrand factor type C domain

RNA

  1. XR_868761.4 RNA Sequence

  2. XR_003956221.2 RNA Sequence

  3. XR_003956220.2 RNA Sequence

  4. XR_003956222.2 RNA Sequence

    Related
    ENSMUST00000091391.11
  5. XR_004942978.1 RNA Sequence

  6. XR_868762.4 RNA Sequence