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KCP kielin cysteine rich BMP regulator [ Homo sapiens (human) ]

Gene ID: 375616, updated on 11-Jun-2021

Summary

Official Symbol
KCPprovided by HGNC
Official Full Name
kielin cysteine rich BMP regulatorprovided by HGNC
Primary source
HGNC:HGNC:17585
See related
Ensembl:ENSG00000135253 MIM:609344
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KCP1; CRIM2; NET67
Expression
Biased expression in kidney (RPKM 3.0), fat (RPKM 0.8) and 8 other tissues See more
Orthologs
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Genomic context

See KCP in Genome Data Viewer
Location:
7q32.1
Exon count:
46
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (128870645..128910719, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (128516919..128550763, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene filamin C Neighboring gene FLNC antisense RNA 1 Neighboring gene ATPase H+ transporting V1 subunit F Neighboring gene ATP6V1F neighbor Neighboring gene uncharacterized LOC105375497 Neighboring gene filamin C pseudogene Neighboring gene Sharpr-MPRA regulatory region 2205

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in hematopoietic progenitor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kielin/chordin-like protein
Names
cysteine rich BMP regulator 2 (chordin-like)
cysteine-rich motor neuron 2 protein
kielin/chordin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001366122.1NP_001353051.1  kielin/chordin-like protein isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC025594, KF495713, KF510975
    Related
    ENSP00000479679.1, ENST00000610776.4
    Conserved Domains (5) summary
    pfam00093
    Location:138188
    VWC; von Willebrand factor type C domain
    pfam00094
    Location:12751424
    VWD; von Willebrand factor type D domain
    pfam01826
    Location:15501603
    TIL; Trypsin Inhibitor like cysteine rich domain
    pfam08742
    Location:14721539
    C8; C8 domain
    cl17735
    Location:12111268
    VWC; von Willebrand factor type C domain
  2. NM_199349.3NP_955381.2  kielin/chordin-like protein isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC025594, AK095464, AK122706
    UniProtKB/Swiss-Prot
    Q6ZWJ8
    Related
    ENST00000612224.1
    Conserved Domains (2) summary
    pfam00093
    Location:138188
    VWC; von Willebrand factor type C domain
    cl17735
    Location:192248
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    128870645..128910719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012188.1XP_016867677.1  kielin/chordin-like protein isoform X4

  2. XM_017012189.1XP_016867678.1  kielin/chordin-like protein isoform X5

  3. XM_017012186.1XP_016867675.1  kielin/chordin-like protein isoform X3

  4. XM_017012187.1XP_016867676.1  kielin/chordin-like protein isoform X3

  5. XM_017012184.1XP_016867673.1  kielin/chordin-like protein isoform X1

  6. XM_017012191.1XP_016867680.1  kielin/chordin-like protein isoform X7

  7. XM_017012192.2XP_016867681.1  kielin/chordin-like protein isoform X7

  8. XM_017012190.1XP_016867679.1  kielin/chordin-like protein isoform X6

    Related
    ENSP00000480867.1, ENST00000611280.4
  9. XM_017012194.1XP_016867683.1  kielin/chordin-like protein isoform X9

  10. XM_017012193.1XP_016867682.1  kielin/chordin-like protein isoform X8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001135914.1: Suppressed sequence

    Description
    NM_001135914.1: This RefSeq has been removed because currently there is insufficient support for the transcript and protein.
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