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HES1 hes family bHLH transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 3280, updated on 21-Dec-2019

Summary

Official Symbol
HES1provided by HGNC
Official Full Name
hes family bHLH transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:5192
See related
Ensembl:ENSG00000114315 MIM:139605
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHL; HRY; HES-1; bHLHb39
Summary
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 46.7), thyroid (RPKM 44.9) and 24 other tissues See more
Orthologs

Genomic context

See HES1 in Genome Data Viewer
Location:
3q29
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (194136148..194138732)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (193853931..193856401)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2026 Neighboring gene developmental pluripotency associated 2 pseudogene 3 Neighboring gene long intergenic non-protein coding RNA 2028 Neighboring gene uncharacterized LOC102724877 Neighboring gene RNA, 7SL, cytoplasmic 215, pseudogene Neighboring gene uncharacterized LOC107986172

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of hairy and enhancer of split 1 (HES1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-box binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
N-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
chaperone binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
S-shaped body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
adenohypophysis development IEA
Inferred from Electronic Annotation
more info
 
anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
ascending aorta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac neural crest cell development involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell maturation IEA
Inferred from Electronic Annotation
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis involved in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
cochlea development IEA
Inferred from Electronic Annotation
more info
 
comma-shaped body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
common bile duct development IEA
Inferred from Electronic Annotation
more info
 
embryonic heart tube morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of epithelial cell polarity IEA
Inferred from Electronic Annotation
more info
 
forebrain radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
glomerulus vasculature development IEA
Inferred from Electronic Annotation
more info
 
hindbrain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
inner ear receptor cell stereocilium organization IEA
Inferred from Electronic Annotation
more info
 
labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
lateral inhibition IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
metanephric nephron tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
midbrain-hindbrain boundary morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell fate determination IEA
Inferred from Electronic Annotation
more info
 
negative regulation of forebrain neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of inner ear auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of pancreatic A cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of pro-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of stomach neuroendocrine cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development TAS
Traceable Author Statement
more info
PubMed 
neuronal stem cell population maintenance IEP
Inferred from Expression Pattern
more info
PubMed 
oculomotor nerve development IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
pancreas development IEA
Inferred from Electronic Annotation
more info
 
pharyngeal arch artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JAK-STAT cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitotic cell cycle, embryonic ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of JAK-STAT cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of timing of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
renal interstitial fibroblast development IEA
Inferred from Electronic Annotation
more info
 
smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
telencephalon development IEA
Inferred from Electronic Annotation
more info
 
thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
trochlear nerve development IEA
Inferred from Electronic Annotation
more info
 
ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
vascular smooth muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular septum development ISS
Inferred from Sequence or Structural Similarity
more info
 
ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
transcription factor HES-1
Names
class B basic helix-loop-helix protein 39
hairy homolog
hairy-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005524.4NP_005515.1  transcription factor HES-1

    See identical proteins and their annotated locations for NP_005515.1

    Status: REVIEWED

    Source sequence(s)
    AC080129, AI370424, AK000415
    Consensus CDS
    CCDS3305.1
    UniProtKB/Swiss-Prot
    Q14469
    Related
    ENSP00000232424.3, ENST00000232424.4
    Conserved Domains (2) summary
    cd00083
    Location:3295
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam07527
    Location:110148
    Hairy_orange; Hairy Orange

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    194136148..194138732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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