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HES1 hes family bHLH transcription factor 1 [ Homo sapiens (human) ]

Gene ID: 3280, updated on 13-May-2022

Summary

Official Symbol
HES1provided by HGNC
Official Full Name
hes family bHLH transcription factor 1provided by HGNC
Primary source
HGNC:HGNC:5192
See related
Ensembl:ENSG00000114315 MIM:139605; AllianceGenome:HGNC:5192
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HHL; HRY; HES-1; bHLHb39
Summary
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 46.7), thyroid (RPKM 44.9) and 24 other tissues See more
Orthologs
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Genomic context

See HES1 in Genome Data Viewer
Location:
3q29
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (194136148..194138732)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (196832819..196835403)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (193853937..193856521)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2028 Neighboring gene uncharacterized LOC102724877 Neighboring gene Sharpr-MPRA regulatory region 14852 Neighboring gene RNA, 7SL, cytoplasmic 215, pseudogene Neighboring gene uncharacterized LOC107986172

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of hairy and enhancer of split 1 (HES1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20408

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables E-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables HLH domain binding IEA
Inferred from Electronic Annotation
more info
 
enables JUN kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables N-box binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N-box binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chaperone binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in S-shaped body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in adenohypophysis development IEA
Inferred from Electronic Annotation
more info
 
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ascending aorta morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cardiac neural crest cell development involved in outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in cell morphogenesis involved in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
 
involved_in cochlea development IEA
Inferred from Electronic Annotation
more info
 
involved_in comma-shaped body morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in common bile duct development IEA
Inferred from Electronic Annotation
more info
 
involved_in embryonic heart tube morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of epithelial cell polarity IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glomerulus vasculature development IEA
Inferred from Electronic Annotation
more info
 
involved_in hair cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in hindbrain morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in inner ear receptor cell stereocilium organization IEA
Inferred from Electronic Annotation
more info
 
involved_in labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
 
involved_in lateral inhibition IEA
Inferred from Electronic Annotation
more info
 
involved_in liver development IEA
Inferred from Electronic Annotation
more info
 
involved_in lung development IEA
Inferred from Electronic Annotation
more info
 
involved_in metanephric nephron tubule morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in midbrain development IEA
Inferred from Electronic Annotation
more info
 
involved_in midbrain-hindbrain boundary morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of calcium ion import IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell fate determination IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of forebrain neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of glial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of inner ear auditory receptor cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of pancreatic A cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of pro-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of stomach neuroendocrine cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in nervous system development TAS
Traceable Author Statement
more info
PubMed 
involved_in neuronal stem cell population maintenance IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in oculomotor nerve development IEA
Inferred from Electronic Annotation
more info
 
involved_in outflow tract morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in pancreas development IEA
Inferred from Electronic Annotation
more info
 
involved_in pharyngeal arch artery morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of BMP signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of astrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of mitotic cell cycle, embryonic ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of tyrosine phosphorylation of STAT protein ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of receptor signaling pathway via JAK-STAT ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of secondary heart field cardioblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of timing of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in renal interstitial fibroblast development IEA
Inferred from Electronic Annotation
more info
 
involved_in response to alkaloid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
involved_in response to thyroid hormone IEA
Inferred from Electronic Annotation
more info
 
involved_in smoothened signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
involved_in telencephalon development IEA
Inferred from Electronic Annotation
more info
 
involved_in thymus development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in trochlear nerve development IEA
Inferred from Electronic Annotation
more info
 
involved_in ureteric bud morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular associated smooth muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ventricular septum development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ventricular septum morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in chromatin IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transcription factor HES-1
Names
class B basic helix-loop-helix protein 39
hairy homolog
hairy-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005524.4NP_005515.1  transcription factor HES-1

    See identical proteins and their annotated locations for NP_005515.1

    Status: REVIEWED

    Source sequence(s)
    AC080129, AI370424, AK000415
    Consensus CDS
    CCDS3305.1
    UniProtKB/Swiss-Prot
    Q14469
    Related
    ENSP00000232424.3, ENST00000232424.4
    Conserved Domains (2) summary
    cd11459
    Location:3395
    bHLH-O_HES1_4; basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split HES-1, HES-4 and similar proteins
    pfam07527
    Location:110148
    Hairy_orange; Hairy Orange

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    194136148..194138732
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    196832819..196835403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)