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Hes1 hes family bHLH transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 15205, updated on 31-Jan-2023

Summary

Official Symbol
Hes1provided by MGI
Official Full Name
hes family bHLH transcription factor 1provided by MGI
Primary source
MGI:MGI:104853
See related
Ensembl:ENSMUSG00000022528 AllianceGenome:MGI:104853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hry; bHLHb39
Summary
Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; HLH domain binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including circulatory system development; regulation of gliogenesis; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; negative regulation of cell differentiation; and nervous system development. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; foot bone; and sensory organ. Orthologous to human HES1 (hes family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in stomach adult (RPKM 82.2), colon adult (RPKM 65.6) and 21 other tissues See more
Orthologs
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Genomic context

See Hes1 in Genome Data Viewer
Location:
16 B2; 16 21.09 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (29884175..29886614)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (30065357..30067796)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4632428C04 gene Neighboring gene RIKEN cDNA 9030404E10 gene Neighboring gene predicted gene, 32998 Neighboring gene predicted gene, 20040

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables HLH domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables JUN kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables N-box binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables N-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables N-box binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chaperone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Cajal-Retzius cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Notch signaling pathway NAS
Non-traceable Author Statement
more info
PubMed 
involved_in Notch signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in S-shaped body morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adenohypophysis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of amacrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in anterior/posterior pattern specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ascending aorta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac neural crest cell development involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell maturation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis involved in neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cochlea development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cochlea development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in comma-shaped body morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within common bile duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic heart tube morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of enteroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of epithelial cell polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in forebrain radial glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in glomerulus vasculature development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in hair cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hindbrain morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inhibition of neuroepithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of inner ear auditory receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell stereocilium organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in metanephric nephron tubule morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of amacrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of forebrain neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of inner ear auditory receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inner ear receptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of pancreatic A cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of pro-B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of stomach neuroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within oculomotor nerve development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of pancreatic A cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pituitary gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pituitary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of neurogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of secondary heart field cardioblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of timing of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of timing of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of timing of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in renal interstitial fibroblast development IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stomach neuroendocrine cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within telencephalon development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within telencephalon development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trochlear nerve development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ureteric bud morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in vascular associated smooth muscle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcription factor HES-1
Names
hairy and enhancer of split 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413568.1NP_001400497.1  transcription factor HES-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT030736
  2. NM_008235.3NP_032261.1  transcription factor HES-1 isoform 1

    See identical proteins and their annotated locations for NP_032261.1

    Status: VALIDATED

    Source sequence(s)
    CT030736
    Consensus CDS
    CCDS28098.1
    UniProtKB/Swiss-Prot
    P35428
    UniProtKB/TrEMBL
    Q3UZZ2
    Related
    ENSMUSP00000023171.8, ENSMUST00000023171.8
    Conserved Domains (2) summary
    cd00083
    Location:3295
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    pfam07527
    Location:110148
    Hairy_orange; Hairy Orange

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    29884175..29886614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521797.4XP_006521860.1  transcription factor HES-1 isoform X1

    Conserved Domains (1) summary
    pfam07527
    Location:131
    Hairy_orange; Hairy Orange