U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KRT73 keratin 73 [ Homo sapiens (human) ]

Gene ID: 319101, updated on 4-Feb-2024

Summary

Official Symbol
KRT73provided by HGNC
Official Full Name
keratin 73provided by HGNC
Primary source
HGNC:HGNC:28928
See related
Ensembl:ENSG00000186049 MIM:608247; AllianceGenome:HGNC:28928
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K73; CK-73; K6IRS3; IRT6IRS3; KRT6IRS3
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Expression
Biased expression in skin (RPKM 2.3), lymph node (RPKM 0.7) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See KRT73 in Genome Data Viewer
Location:
12q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (52607570..52630761, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (52572166..52596120, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53001354..53012343, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29072 Neighboring gene keratin 74 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29100 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29110 Neighboring gene keratin 72 Neighboring gene KRT73 antisense RNA 1 Neighboring gene keratin 128, pseudogene Neighboring gene keratin 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC129635, MGC129636

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of skin epidermis IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in intermediate filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in keratinization IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
is_active_in keratin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type II cytoskeletal 73
Names
cytokeratin-73
keratin 6 irs3
keratin 73, type II
type II inner root sheath-specific keratin-K6irs3
type-II keratin Kb36

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012319.1 RefSeqGene

    Range
    5001..15990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175068.3NP_778238.1  keratin, type II cytoskeletal 73

    See identical proteins and their annotated locations for NP_778238.1

    Status: REVIEWED

    Source sequence(s)
    AJ508776
    Consensus CDS
    CCDS8834.1
    UniProtKB/Swiss-Prot
    Q32MB2, Q86Y46
    Related
    ENSP00000307014.3, ENST00000305748.7
    Conserved Domains (4) summary
    pfam00038
    Location:131444
    Filament; Intermediate filament protein
    pfam16208
    Location:16128
    Keratin_2_head; Keratin type II head
    cl01503
    Location:1093
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    cl09176
    Location:298429
    FlgN; FlgN protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    52607570..52630761 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428761.1XP_047284717.1  keratin, type II cytoskeletal 73 isoform X1

    UniProtKB/Swiss-Prot
    Q32MB2, Q86Y46

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    52572166..52596120 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054371913.1XP_054227888.1  keratin, type II cytoskeletal 73 isoform X1

    UniProtKB/Swiss-Prot
    Q32MB2, Q86Y46