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KRT73 keratin 73 [ Homo sapiens (human) ]

Gene ID: 319101, updated on 8-Jul-2021

Summary

Official Symbol
KRT73provided by HGNC
Official Full Name
keratin 73provided by HGNC
Primary source
HGNC:HGNC:28928
See related
Ensembl:ENSG00000186049 MIM:608247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K73; CK-73; K6IRS3; IRT6IRS3; KRT6IRS3
Summary
Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene encodes a protein that is expressed in the inner root sheath of hair follicles. The type II keratins are clustered in a region of chromosome 12q13.[provided by RefSeq, Jun 2009]
Expression
Biased expression in skin (RPKM 2.3), lymph node (RPKM 0.7) and 5 other tissues See more
Orthologs
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Genomic context

See KRT73 in Genome Data Viewer
Location:
12q13.13
Exon count:
11
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (52601813..52620133, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53001354..53012343, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene keratin 71 Neighboring gene keratin 74 Neighboring gene keratin 72 Neighboring gene KRT73 antisense RNA 1 Neighboring gene uncharacterized LOC105369772 Neighboring gene keratin 128 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC129635, MGC129636

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 

General protein information

Preferred Names
keratin, type II cytoskeletal 73
Names
cytokeratin-73
keratin 6 irs3
keratin 73, type II
type II inner root sheath-specific keratin-K6irs3
type-II keratin Kb36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012319.1 RefSeqGene

    Range
    5001..15990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_175068.3NP_778238.1  keratin, type II cytoskeletal 73

    See identical proteins and their annotated locations for NP_778238.1

    Status: REVIEWED

    Source sequence(s)
    AJ508776
    Consensus CDS
    CCDS8834.1
    UniProtKB/Swiss-Prot
    Q86Y46
    Related
    ENSP00000307014.3, ENST00000305748.7
    Conserved Domains (4) summary
    pfam00038
    Location:131444
    Filament; Intermediate filament protein
    pfam16208
    Location:16128
    Keratin_2_head; Keratin type II head
    cl01503
    Location:1093
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    cl09176
    Location:298429
    FlgN; FlgN protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    52601813..52620133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538257.2XP_011536559.1  keratin, type II cytoskeletal 73 isoform X1

    Conserved Domains (4) summary
    pfam00038
    Location:131412
    Filament; Intermediate filament protein
    pfam16208
    Location:16128
    Keratin_2_head; Keratin type II head
    cl01503
    Location:1093
    TrbL; TrbL/VirB6 plasmid conjugal transfer protein
    cl19219
    Location:308388
    DUF342; Protein of unknown function (DUF342)

RNA

  1. XR_001748677.1 RNA Sequence

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