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MR1 major histocompatibility complex, class I-related [ Homo sapiens (human) ]

Gene ID: 3140, updated on 5-Apr-2020

Summary

Official Symbol
MR1provided by HGNC
Official Full Name
major histocompatibility complex, class I-relatedprovided by HGNC
Primary source
HGNC:HGNC:4975
See related
Ensembl:ENSG00000153029 MIM:600764
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLALS
Summary
MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]
Expression
Ubiquitous expression in urinary bladder (RPKM 6.3), thyroid (RPKM 5.6) and 24 other tissues See more
Orthologs

Genomic context

See MR1 in Genome Data Viewer
Location:
1q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (181033392..181061938)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (181002561..181031074)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene major histocompatibility complex, class I-related pseudogene Neighboring gene syntaxin 6 Neighboring gene immediate early response 5 Neighboring gene CRISPRi-validated cis-regulatory element chr1.10177

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of major histocompatibility complex, class I-related (MR1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed
Knockdown of major histocompatibility complex, class I-related, isoform 4 (MR1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ31593

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class I receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
 
cytokine production involved in immune response IEA
Inferred from Electronic Annotation
more info
 
defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response TAS
Traceable Author Statement
more info
PubMed 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 beta production IEA
Inferred from Electronic Annotation
more info
 
interleukin-17 production IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
MHC class I protein complex IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
major histocompatibility complex class I-related gene protein
Names
MHC class I-like antigen MR-1
MHC class-I related-gene protein
major histocompatibility complex, class I-like sequence

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042221.1 RefSeqGene

    Range
    5001..33514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001194999.1NP_001181928.1  major histocompatibility complex class I-related gene protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001181928.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AL356267, BC012485, DC297418
    Consensus CDS
    CCDS53442.1
    UniProtKB/Swiss-Prot
    Q95460
    Related
    ENSP00000356551.3, ENST00000367579.7
    Conserved Domains (2) summary
    cd07698
    Location:157249
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:25153
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. NM_001195000.1NP_001181929.1  major histocompatibility complex class I-related gene protein isoform 3 precursor

    See identical proteins and their annotated locations for NP_001181929.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AF031469, AL356267, DC297418
    Consensus CDS
    CCDS53440.1
    UniProtKB/Swiss-Prot
    Q95460
    Related
    ENSP00000478976.1, ENST00000617803.4
    Conserved Domains (1) summary
    cl08246
    Location:25198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  3. NM_001195035.1NP_001181964.1  major histocompatibility complex class I-related gene protein isoform 4 precursor

    See identical proteins and their annotated locations for NP_001181964.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two consecutive in-frame exons in the coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
    Source sequence(s)
    AK304645, AL356267, DC297418
    Consensus CDS
    CCDS53441.1
    UniProtKB/Swiss-Prot
    Q95460
    Related
    ENSP00000388504.2, ENST00000434571.6
    Conserved Domains (1) summary
    cl08246
    Location:25198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  4. NM_001310213.1NP_001297142.1  major histocompatibility complex class I-related gene protein isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' end and lacks an alternate in-frame exon compared to variant 1, which results in translation initiation at a downstream start codon compared to variant 1. The encoded isoform (5) is shorter at the N-terminus and lacks an internal segment compared to isoform 1.
    Source sequence(s)
    AL356267, BX415555, CA426202, DC297418
    Conserved Domains (1) summary
    cl08246
    Location:6127
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  5. NM_001531.2NP_001522.1  major histocompatibility complex class I-related gene protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001522.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL356267, DC297418, U22963
    Consensus CDS
    CCDS1342.1
    UniProtKB/Swiss-Prot
    Q95460
    Related
    ENSP00000477563.1, ENST00000614012.4
    Conserved Domains (2) summary
    cd07698
    Location:202294
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:25198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    181033392..181061938
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509463.2XP_011507765.1  major histocompatibility complex class I-related gene protein isoform X2

    Conserved Domains (2) summary
    cd07698
    Location:115207
    IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
    cl08246
    Location:20111
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. XM_024446611.1XP_024302379.1  major histocompatibility complex class I-related gene protein isoform X1

    Conserved Domains (2) summary
    cl08246
    Location:25198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    cl11960
    Location:202265
    Ig; Immunoglobulin domain
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