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HGF hepatocyte growth factor [ Homo sapiens (human) ]

Gene ID: 3082, updated on 28-Jun-2020

Summary

Official Symbol
HGFprovided by HGNC
Official Full Name
hepatocyte growth factorprovided by HGNC
Primary source
HGNC:HGNC:4893
See related
Ensembl:ENSG00000019991 MIM:142409
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SF; HGFB; HPTA; F-TCF; DFNB39
Summary
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
Expression
Biased expression in placenta (RPKM 90.6), adrenal (RPKM 7.0) and 2 other tissues See more
Orthologs

Genomic context

See HGF in Genome Data Viewer
Location:
7q21.11
Exon count:
20
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (81699006..81770438, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (81331444..81399452, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369146 Neighboring gene uncharacterized LOC100128317 Neighboring gene DEAD-box helicase 43 pseudogene 3 Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 1 Neighboring gene CACNA2D1 antisense RNA 1 Neighboring gene uncharacterized LOC107986813

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Scatter factor (SF) attenuates the apoptosis induced by high-doses of HIV-1 gp120 in human mesangial cells (HMC) PubMed
Vpu vpu The gene expression of hepatocyte growth factor (HGF) increases in cells infected with vpu-deficient HIV-1 compared to cells infected with the wild-type virus, indicating that HIV-1 Vpu downregulates HGF protein expression PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
chemoattractant activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular response to hepatocyte growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to hepatocyte growth factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
epithelial to mesenchymal transition TAS
Traceable Author Statement
more info
PubMed 
hepatocyte growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hepatocyte growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle NAS
Non-traceable Author Statement
more info
PubMed 
myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of autophagy NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
Inferred from Electronic Annotation
more info
 
negative regulation of hydrogen peroxide-mediated programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of release of cytochrome c from mitochondria IDA
Inferred from Direct Assay
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of DNA biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-10 production IEA
Inferred from Electronic Annotation
more info
 
positive regulation of myelination IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron projection regeneration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoblast differentiation NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling TAS
Traceable Author Statement
more info
 
positive regulation of protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
NOT proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
regulation of tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hepatocyte growth factor
Names
fibroblast-derived tumor cytotoxic factor
hepatocyte growth factor (hepapoietin A; scatter factor)
hepatopoietin-A
lung fibroblast-derived mitogen

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016274.2 RefSeqGene

    Range
    5090..76127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000601.6NP_000592.3  hepatocyte growth factor isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_000592.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC004960, AV701693, BU533235, BX495370, M29145, M73240
    Consensus CDS
    CCDS5597.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000222390.5, ENST00000222390.11
    Conserved Domains (5) summary
    smart00020
    Location:494716
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:210290
    KR; Kringle domain
    cd00108
    Location:388470
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:495719
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001010931.3NP_001010931.1  hepatocyte growth factor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001010931.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus, compared to isoform 1. Isoform 2, also named NK2, has been shown to act as a competitive antagonist to active hepatocyte growth factor for the c-Met receptor.
    Source sequence(s)
    BM971901, BU533235, BX495370, L02931
    Consensus CDS
    CCDS47627.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000389854.2, ENST00000444829.7
    Conserved Domains (2) summary
    smart00130
    Location:210289
    KR; Kringle domain
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  3. NM_001010932.3NP_001010932.1  hepatocyte growth factor isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001010932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (3) lacks a portion of the alpha chain and is shorter compared to isoform 1.
    Source sequence(s)
    AC004960, AV701693, BU533235, BX495370, M73240
    Consensus CDS
    CCDS47626.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000391238.2, ENST00000457544.7
    Conserved Domains (5) summary
    smart00020
    Location:489711
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:205285
    KR; Kringle domain
    cd00108
    Location:383465
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:490714
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. NM_001010933.3NP_001010933.1  hepatocyte growth factor isoform 4 precursor

    See identical proteins and their annotated locations for NP_001010933.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an internal in-frame segment and multiple 3' exons but includes an alternate 3' exon, compared to variant 1. The resulting protein (isoform 4) lacks an internal segment and has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC022308, BM971901, BU533235, BX495370, L02931
    Consensus CDS
    CCDS47628.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000408270.1, ENST00000453411.6
    Conserved Domains (2) summary
    smart00130
    Location:205284
    KR; Kringle domain
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  5. NM_001010934.3NP_001010934.1  hepatocyte growth factor isoform 5 precursor

    See identical proteins and their annotated locations for NP_001010934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks multiple 3' exons but has an alternate 3' segment, compared to variant 1. The resulting protein (isoform 5) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC063485, BU533235, BX495370, U46010
    Consensus CDS
    CCDS47629.1
    UniProtKB/Swiss-Prot
    P14210
    Related
    ENSP00000413829.2, ENST00000423064.7
    Conserved Domains (2) summary
    smart00130
    Location:126208
    KR; Kringle domain
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    81699006..81770438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715956.2XP_006716019.1  hepatocyte growth factor isoform X1

    See identical proteins and their annotated locations for XP_006716019.1

    UniProtKB/Swiss-Prot
    P14210
    Conserved Domains (5) summary
    smart00020
    Location:494716
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:210290
    KR; Kringle domain
    cd00108
    Location:388470
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:495719
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. XM_011516115.2XP_011514417.1  hepatocyte growth factor isoform X2

    See identical proteins and their annotated locations for XP_011514417.1

    UniProtKB/Swiss-Prot
    P14210
    Conserved Domains (5) summary
    smart00020
    Location:489711
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:205285
    KR; Kringle domain
    cd00108
    Location:383465
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:490714
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. XM_017012098.1XP_016867587.1  hepatocyte growth factor isoform X4

    UniProtKB/Swiss-Prot
    P14210
    Conserved Domains (2) summary
    smart00130
    Location:205284
    KR; Kringle domain
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  4. XM_017012097.1XP_016867586.1  hepatocyte growth factor isoform X3

    UniProtKB/Swiss-Prot
    P14210
    Conserved Domains (2) summary
    smart00130
    Location:210289
    KR; Kringle domain
    cd00129
    Location:39122
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
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