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Hgf hepatocyte growth factor [ Mus musculus (house mouse) ]

Gene ID: 15234, updated on 18-Sep-2024

Summary

Official Symbol
Hgfprovided by MGI
Official Full Name
hepatocyte growth factorprovided by MGI
Primary source
MGI:MGI:96079
See related
Ensembl:ENSMUSG00000028864 AllianceGenome:MGI:96079
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SF; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik
Summary
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in lung adult (RPKM 1.6), bladder adult (RPKM 1.4) and 21 other tissues See more
Orthologs
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Genomic context

See Hgf in Genome Data Viewer
Location:
5 A3; 5 7.07 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (16758493..16827448)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (16553495..16619439)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 54320 Neighboring gene predicted gene, 31113 Neighboring gene STARR-seq mESC enhancer starr_12489 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene VISTA enhancer mm1576 Neighboring gene cadherin related family member 17 Neighboring gene STARR-seq mESC enhancer starr_12490

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity IEA
Inferred from Electronic Annotation
more info
 
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
NOT enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cell chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hepatocyte growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hepatocyte growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepatocyte growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within hepatocyte growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in hepatocyte growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within liver development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of hydrogen peroxide-mediated programmed cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of p38MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of tau-protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
hepatocyte growth factor
Names
hepatopoietin-A
scatter factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289458.1NP_001276387.1  hepatocyte growth factor isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001276387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AC161176, AK042121, AK052289, BC119228
    Consensus CDS
    CCDS19097.1
    UniProtKB/Swiss-Prot
    O55027, Q08048, Q53WS5, Q61662, Q64007, Q6LBE6
    UniProtKB/TrEMBL
    Q8C9G5
    Conserved Domains (4) summary
    smart00020
    Location:495719
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211289
    KR; Kringle domain
    cd00108
    Location:389471
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  2. NM_001289459.1NP_001276388.1  hepatocyte growth factor isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001276388.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK042121, AK052289, BC119228
    Consensus CDS
    CCDS19097.1
    UniProtKB/Swiss-Prot
    O55027, Q08048, Q53WS5, Q61662, Q64007, Q6LBE6
    UniProtKB/TrEMBL
    Q8C9G5
    Conserved Domains (4) summary
    smart00020
    Location:495719
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211289
    KR; Kringle domain
    cd00108
    Location:389471
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  3. NM_001289460.2NP_001276389.1  hepatocyte growth factor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001276389.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple 3' coding exons and its 3' terminal exon extends past a splice site used in variant 1, resulting in a different 3' coding region and 3' UTR. The encoded isoform (2) lacks most of the alpha chain and the entire beta chain, has a distinct C-terminus and is shorter compared to isoform 1.
    Source sequence(s)
    AC161176, AK052289, AK164241
    UniProtKB/Swiss-Prot
    Q08048
    Conserved Domains (2) summary
    smart00130
    Location:127209
    KR; Kringle domain
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
  4. NM_001289461.1NP_001276390.1  hepatocyte growth factor isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001276390.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC161176
    Consensus CDS
    CCDS80213.1
    UniProtKB/TrEMBL
    Q8C9G5
    Related
    ENSMUSP00000142517.2, ENSMUST00000196645.2
    Conserved Domains (5) summary
    smart00020
    Location:490714
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:206284
    KR; Kringle domain
    cd00108
    Location:384466
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...
    cd00190
    Location:503717
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  5. NM_010427.5NP_034557.3  hepatocyte growth factor isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_034557.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same isoform (1).
    Source sequence(s)
    AK042121, AK052289, BC119228
    Consensus CDS
    CCDS19097.1
    UniProtKB/Swiss-Prot
    O55027, Q08048, Q53WS5, Q61662, Q64007, Q6LBE6
    UniProtKB/TrEMBL
    Q8C9G5
    Related
    ENSMUSP00000143424.2, ENSMUST00000199581.5
    Conserved Domains (4) summary
    smart00020
    Location:495719
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211289
    KR; Kringle domain
    cd00108
    Location:389471
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    16758493..16827448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164820.1XP_036020713.1  hepatocyte growth factor isoform X1

    UniProtKB/Swiss-Prot
    O55027, Q08048, Q53WS5, Q61662, Q64007, Q6LBE6
    UniProtKB/TrEMBL
    Q8C9G5
    Related
    ENSMUSP00000030683.4, ENSMUST00000030683.8
    Conserved Domains (4) summary
    smart00020
    Location:495719
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:211289
    KR; Kringle domain
    cd00108
    Location:389471
    KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    cd00129
    Location:41123
    PAN_APPLE; PAN/APPLE-like domain; present in N-terminal (N) domains of plasminogen/ hepatocyte growth factor proteins, plasma prekallikrein/coagulation factor XI and microneme antigen proteins, plant receptor-like protein kinases, and various nematode and leech ...