Conserved Protein Domain Family
Tryp_SPc

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smart00020: Tryp_SPc 
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Trypsin-like serine protease
Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.
Statistics
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PSSM-Id: 214473
View PSSM: smart00020
Aligned: 189 rows
Threshold Bit Score: 120.09
Threshold Setting Gi: 116116
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z8G_A      117 RIVGGR-DTSLGRWPWQVSLRYdg--------------aHLCGGSLLSGDWVLTAAHCFpeRNRv-------lSRWRVFA 174
gi 74957569 107 RVLGGQ-PTKIDEFPWTALIEYekpn---------grfgFHCGGSVINERYILTAAHCI--TSipr-----gwKVHRVRL 169
gi 74763079 471 QASGGKiIKRRGEWPWMTLVDLgdneakgkygisglngtNYCGGSLVDENIVITAAHCV--ELRnp-------sDITAWF 541
gi 82228403 469 RIAGGD-PTKIELWPWQAQISMrvhisn------dhvkpAFCGGSIIAEQWILTAAHCF--DEFaitddewwrGSIDVVI 539
gi 71992117  15 ESCGIQqESKIKNFPWAVSFTVdg--------------vNRLGGSIISPYHIITAAHG-----------------FITTI 63
gi 71984548  37 RIIGGN--SIDDGANWMAKLVSygdn----------gqgILCGATVIDDFWLVTAAHCA--L--------------QLQT 88
gi 2738865  160 LIVGGV-NASRNEFPHMVLLGFnttt----------gisWMCGGSLISEKFILTAGHCV--MHKd---------FGDVKY 217
gi 2738869   27 GVAGGH-EIPISDAPFVASIIRyknktq------pkttvMIFGGSVIHERFILTAAHCF--LMYen------lTSEVIRV 91
gi 2738867   30 GIYGGH-DISIEQAPFMASLRLng-------------tdHYCGASVIHERFILTAAHCI--LPDr---------KYTVQV 84
gi 38258901 127 RIYGGM-KTKIDEFPWMALIEYtksq---------gkkgHHCGGSLISTRYVITASHCV--NGKalp---tdwRLSGVRL 191
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z8G_A      175 GAVAQASPHGL---------------------------------------------------Q-LGVQAVV-YHGGYlpf 201
gi 74957569 170 GEWDLSSTTDQeddfy------------------------------------------adapIdLDIEKII-VHPGY--- 203
gi 74763079 542 GVDDRSINDNIv--------------------------------------------------QkRDILEIN-IHQDY--- 567
gi 82228403 540 GSSNKLGGDKIs-------------------------------------------------pKqIIIHEGYnRNPDA--- 567
gi 71992117  64 GSRGNLCENKNwkkpnssiyrsikflrdtrkvayggtcirghtdkypndprckksdvihnkvRaVLVDGEFaSSNCL--- 140
gi 71984548  89 RSFVYVREPKNnr------------------------------------------------eRsFSVKEAY-IHSGY--- 116
gi 2738865  218 ASIGVLSRGEVtp------------------------------------------------eNtYKVKRSV-RHPQY--- 245
gi 2738869   92 GSAQLGVGG-----------------------------------------------------TtYEVEKVI-IHENF--- 114
gi 2738867   85 GTTYANDGG-----------------------------------------------------QvYDVEKIM-KHEMY--- 107
gi 38258901 192 GEWDTNTNPDCevdvrgm-------------------------------------kdcapphLdVPVERTI-PHPDY--- 230
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z8G_A      202 rdpNS-----EENSNDIALVHLSSPlpLTEYIQPVCLPAA--------------------------GQALVD-GKIcTVT 249
gi 74957569 204 ---NLq---dKSHHNDIALIRFNREinYSSTIRAICLPLSn------------------------sLRNRKHaGLSsYAA 253
gi 74763079 568 ---ENkr-htTPFDSDIAVLKLDSPvtLTPVVRPICLPLTetekqlp-------------qksqnpQHNVNT-WYKgVVT 629
gi 82228403 568 ---HVq---iENLDNDIALIKLSKRltFGYTYRPICLPCTketnaildlnsankdwttlcnihgknLIDVKK-NTSlTVT 640
gi 71992117 141 ---KG---------HDWAIVEVEKRihFSENVRPICLPRP---------------------------NMYYT--KSlAVP 179
gi 71984548 117 ---NN-----QTADNDIALLRISSDlsKLG-IKPVCLVHDd-------------------------SKLLKQ-YKNgVVI 161
gi 2738865  246 ---R------IDVYNDIAVIELEKEvtLDAFTVPACLHVG---------------------------DPIDY--SRaIAA 287
gi 2738869  115 ---NPnnnmsLAFSHDIALLKLKEKycLHE-MYLNSLADK--------------------------DLEIVP-YTLaNVT 163
gi 2738867  108 ---NY-----TTHDYDICLIKLKTNltFSAKVNKIDLADR--------------------------SVRLKQ-NIQvEVT 152
gi 38258901 231 ---IPa---sKNQVNDIALLRLAQQveYTDFVRPICLPLDv------------------------nLRSATFdGITmDVA 280
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1Z8G_A      250 GWGNTQY------Y-GQQAGVLQEARVPIISNDV---CNG---ADFYG------NQIKPKMFCAGYPE----GGIDACQG 306
gi 74957569 254 GWGKTET--------ASASQKKLKVELTVVDVKD---CSP---VYQRNg-----ISLDSTQMCAGGVR-----GKDTCSG 309
gi 74763079 630 GWGKTEVg--------TLSNHLLKVRLPFVSNEV---CQTgydELYEH------ITITENMICAGYPG----GHRDACKG 688
gi 82228403 641 GFGLLEGd-------KKHAQQLQQATVQYAKKEV---CLKdimARFNVteekaeKHITENMLCAWNAT------ADTCRG 704
gi 71992117 180 GWGRifn--------------esGPLIHEIPMRIdrdCKR---PWSDRl-----PADADDFICATSMNvsnySAPRTCHG 237
gi 71984548 162 GYGLTLGedssgePkLINSQTLQSTSVPIISDDD---CVKtwrFLSLLs-----VKITGYQICAGAYL------HGTAPG 227
gi 2738865  288 GWGLLED------RgATPSDVMQKVIVKKIRKVT---CQR---DYPGDtsavaaKYDSESQLCYGDRQ----EKKDTCHG 351
gi 2738869  164 GWVDLAIr--------QYFKDTT-ASISRDKPIDe--CK-----MYP--------WACKDEICIKSYN------KGSCKG 213
gi 2738867  153 GWGATS-------AdGDISNNLQQVTIPIISTFSc--CLK---YLKVR------HAITSRMFCAGEQ------GKDSCQG 208
gi 38258901 281 GWGKTEQ--------LSASNLKLKAAVEGSRMDE---CQN---VYSSQd-----ILLEDTQMCAGGKE-----GVDSCRG 336
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*.
1Z8G_A      307 DSGGPFVCEDsisrtpRWRLCGIVSWGt------GCA-LAQKPGVYTKVSDFREWI 355
gi 74957569 310 DSGGPLMRQMt----gSWYLIGVVSFGp-----qKCG-APGVPGVYTNVAEYVDWI 355
gi 74763079 689 DSGGPLMFPDri--tnTWFLNGIVSFGdssdrenFCG-QARTYGAYTNVGKFIDWI 741
gi 82228403 705 DSGGPLVLQKn----rRWIQVGIVAGGva----qHCG-KNIKSSFYTNVAKMMPWV 751
gi 71992117 238 DSGGGLEYRDdn--ygRAFLIAITSFGt-----rGCP--SNMLARFTRVDMYLNLI 284
gi 71984548 228 DSGGPLLIHKsn---gEYVQIGITSYGadg--ldGVIdQGKFPGvytriskyvpwi 278
gi 2738865  352 DSGGPLQLKHkki-ncMYLVIGVTSGGk------GCA-LRNRPGLYSKVSHYLDWI 399
gi 2738869  214 DSGGPLTMHG--------VQVGIVSNGl------GCG---TMPTIHTKISFLRPWI 252
gi 2738867  209 DSGGPLTLNN--------VQVGVTSFGs------GCG---KLPGVYTKISAMLPWI 247
gi 38258901 337 DSGGPLIGLDtnkvntYYFLAGVVSFGp-----tPCG-LAGWPGVYTLVGKYVDWI 386
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