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ANXA5 annexin A5 [ Homo sapiens (human) ]

Gene ID: 308, updated on 13-Jan-2020

Summary

Official Symbol
ANXA5provided by HGNC
Official Full Name
annexin A5provided by HGNC
Primary source
HGNC:HGNC:543
See related
Ensembl:ENSG00000164111 MIM:131230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP4; ANX5; ENX2; RPRGL3; HEL-S-7
Summary
The Annexin 5 gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa.The protein encoded by this gene belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin 5 is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. Annexin 5 has also been described as placental anticoagulant protein I, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4 and anchorin CII. Polymorphisms in this gene have been implicated in various obstetric complications. [provided by RefSeq, Dec 2019]
Expression
Ubiquitous expression in fat (RPKM 198.4), placenta (RPKM 170.8) and 25 other tissues See more
Orthologs

Genomic context

See ANXA5 in Genome Data Viewer
Location:
4q27
Exon count:
14
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (121667946..121696994, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (122589152..122618147, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377401 Neighboring gene uncharacterized LOC105377402 Neighboring gene transmembrane protein 155 Neighboring gene uncharacterized LOC100192379 Neighboring gene exosome component 9 Neighboring gene cyclin A2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Pregnancy loss, recurrent, susceptibility to, 3
MedGen: C3280674 OMIM: 614391 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of smoking behaviours in patients with COPD.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of annexin A5 (ANXA5) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of annexin A4 and A5 in umbilical cord blood mononuclear cells and T-cell lines but downregulates the expression of annexin A1 in umbilical cord blood mononuclear cells PubMed
Tat tat HIV-1 Tat-induced programmed neuronal cell death involves downregulation of annexin 5 PubMed
tat HIV-1 Tat is strongly associated with ANXA5 in HIV-1-infected lymphocytic cells PubMed
capsid gag HIV-1 CA is strongly associated with ANXA5 in HIV-1-infected lymphocytic cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-transporting ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
cellular response to gonadotropin-releasing hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to lead ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
negative regulation of blood coagulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of prolactin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of sequestering of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of flagellated sperm motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to organic substance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to thyroid hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endothelial microparticle IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
focal adhesion HDA PubMed 
intracellular IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
annexin A5
Names
CBP-I
PAP-I
VAC-alpha
anchorin CII
annexin V
annexin-5
calphobindin I
endonexin II
epididymis secretory protein Li 7
lipocortin V
placental anticoagulant protein 4
placental anticoagulant protein I
thromboplastin inhibitor
vascular anticoagulant-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032042.1 RefSeqGene

    Range
    5013..34047
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001154.4NP_001145.1  annexin A5

    See identical proteins and their annotated locations for NP_001145.1

    Status: REVIEWED

    Source sequence(s)
    AC096730, AK312644, BC001429, J03745
    Consensus CDS
    CCDS3720.1
    UniProtKB/Swiss-Prot
    P08758
    UniProtKB/TrEMBL
    V9HWE0
    Related
    ENSP00000296511.5, ENST00000296511.10
    Conserved Domains (1) summary
    pfam00191
    Location:2084
    Annexin; Annexin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    121667946..121696994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008141.2XP_016863630.1  annexin A5 isoform X1

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