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DONSON DNA replication fork stabilization factor DONSON [ Homo sapiens (human) ]

Gene ID: 29980, updated on 8-Jul-2021

Summary

Official Symbol
DONSONprovided by HGNC
Official Full Name
DNA replication fork stabilization factor DONSONprovided by HGNC
Primary source
HGNC:HGNC:2993
See related
Ensembl:ENSG00000159147 MIM:611428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B17; MIMIS; MISSLA; C21orf60
Summary
This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 22.3), urinary bladder (RPKM 14.4) and 23 other tissues See more
Orthologs
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Genomic context

See DONSON in Genome Data Viewer
Location:
21q22.11
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (33577551..33588684, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34949857..34960990, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985481 Neighboring gene microRNA 6501 Neighboring gene SON DNA and RNA binding protein Neighboring gene crystallin zeta like 1 Neighboring gene intersectin 1 Neighboring gene H3K27me3-DHS negatively-acting regulatory element H4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434M035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in replication fork protection IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in replication fork IDA
Inferred from Direct Assay
more info
PubMed 
part_of replisome IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein downstream neighbor of Son
Names
downstream neighbor of SON

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017613.4NP_060083.1  protein downstream neighbor of Son

    See identical proteins and their annotated locations for NP_060083.1

    Status: VALIDATED

    Source sequence(s)
    AP000304, BC048266, BI463648, BM451848, BM679236
    Consensus CDS
    CCDS13632.1
    UniProtKB/Swiss-Prot
    Q9NYP3
    Related
    ENSP00000307143.4, ENST00000303071.10

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    33577551..33588684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145794.1: Suppressed sequence

    Description
    NM_145794.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
  2. NM_145795.1: Suppressed sequence

    Description
    NM_145795.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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