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CRYZL1 crystallin zeta like 1 [ Homo sapiens (human) ]

Gene ID: 9946, updated on 11-Jun-2021

Summary

Official Symbol
CRYZL1provided by HGNC
Official Full Name
crystallin zeta like 1provided by HGNC
Primary source
HGNC:HGNC:2420
See related
Ensembl:ENSG00000205758 MIM:603920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
4P11; QOH-1
Summary
This gene encodes a protein that has sequence similarity to zeta crystallin, also known as quinone oxidoreductase. This zeta crystallin-like protein also contains an NAD(P)H binding site. Alternatively spliced transcript variants have been observed but their full-length nature has not been completely determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 17.7), brain (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

See CRYZL1 in Genome Data Viewer
Location:
21q22.11
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (33589341..33641741, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34961647..35014047, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985481 Neighboring gene SON DNA and RNA binding protein Neighboring gene DNA replication fork stabilization factor DONSON Neighboring gene intersectin 1 Neighboring gene H3K27me3-DHS negatively-acting regulatory element H4 Neighboring gene ATP synthase peripheral stalk subunit OSCP

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DONSON

Homology

Clone Names

  • DKFZp434M035

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NADP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables NADPH:quinone reductase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in quinone metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 

General protein information

Preferred Names
quinone oxidoreductase-like protein 1
Names
crystallin, zeta (quinone reductase)-like 1
protein 4P11
quinone oxidoreductase homolog 1
quinone reductase-like 1
zeta-crystallin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145858.3NP_665857.2  quinone oxidoreductase-like protein 1

    See identical proteins and their annotated locations for NP_665857.2

    Status: REVIEWED

    Source sequence(s)
    BC033023, CA426424, DB037192
    Consensus CDS
    CCDS13633.2
    UniProtKB/Swiss-Prot
    O95825
    Related
    ENSP00000370966.3, ENST00000381554.8
    Conserved Domains (1) summary
    cd05195
    Location:31347
    enoyl_red; enoyl reductase of polyketide synthase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    33589341..33641741 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145311.1: Suppressed sequence

    Description
    NM_145311.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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