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ATP5PO ATP synthase peripheral stalk subunit OSCP [ Homo sapiens (human) ]

Gene ID: 539, updated on 5-Jul-2020

Summary

Official Symbol
ATP5POprovided by HGNC
Official Full Name
ATP synthase peripheral stalk subunit OSCPprovided by HGNC
Primary source
HGNC:HGNC:850
See related
Ensembl:ENSG00000241837 MIM:600828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATPO; OSCP; ATP5O; HMC08D05
Summary
The protein encoded by this gene is a component of the F-type ATPase found in the mitochondrial matrix. F-type ATPases are composed of a catalytic core and a membrane proton channel. The encoded protein appears to be part of the connector linking these two components and may be involved in transmission of conformational changes or proton conductance. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 296.0), duodenum (RPKM 137.0) and 25 other tissues See more
Orthologs

Genomic context

See ATP5PO in Genome Data Viewer
Location:
21q22.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (33903453..33915804, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (35275757..35288158, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene crystallin zeta like 1 Neighboring gene intersectin 1 Neighboring gene RNA, 7SL, cytoplasmic 740, pseudogene Neighboring gene long intergenic non-protein coding RNA 649

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify mitochondrial F1 complex ATP synthase O subunit (ATP5O), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify mitochondrial F1 complex ATP synthase O subunit (ATP5O), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify mitochondrial F1 complex ATP synthase O subunit (ATP5O), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify mitochondrial F1 complex ATP synthase O subunit (ATP5O), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit (ATP5O) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
ATP biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
ATP biosynthetic process TAS
Traceable Author Statement
more info
 
cristae formation TAS
Traceable Author Statement
more info
 
mitochondrial ATP synthesis coupled proton transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitochondrial ATP synthesis coupled proton transport TAS
Traceable Author Statement
more info
 
proton transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
ATP synthase subunit O, mitochondrial
Names
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
human ATP synthase OSCP subunit
oligomycin sensitivity conferral protein oscp-like protein
oligomycin sensitivity conferring protein
NP_001688.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001697.3NP_001688.1  ATP synthase subunit O, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001688.1

    Status: REVIEWED

    Source sequence(s)
    AF088071, AV734214, AW518473, CD174837
    Consensus CDS
    CCDS13634.1
    UniProtKB/Swiss-Prot
    P48047
    Related
    ENSP00000290299.2, ENST00000290299.7
    Conserved Domains (1) summary
    pfam00213
    Location:37209
    OSCP; ATP synthase delta (OSCP) subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    33903453..33915804 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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