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Maoa monoamine oxidase A [ Rattus norvegicus (Norway rat) ]

Gene ID: 29253, updated on 18-May-2023

Summary

Official Symbol
Maoaprovided by RGD
Official Full Name
monoamine oxidase Aprovided by RGD
Primary source
RGD:61898
See related
Ensembl:ENSRNOG00000002848 AllianceGenome:RGD:61898
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mao
Summary
Enables flavin adenine dinucleotide binding activity; primary amine oxidase activity; and serotonin binding activity. Involved in phenylethylamine metabolic process and serotonin metabolic process. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (monoamine oxidase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 1152.5), Liver (RPKM 471.7) and 8 other tissues See more
Orthologs
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Genomic context

See Maoa in Genome Data Viewer
Location:
Xq11
Exon count:
15
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (6032172..6098308, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (6554698..6620722, complement)

Chromosome X - NC_051356.1Genomic Context describing neighboring genes Neighboring gene basic leucine zipper nuclear factor 1, pseudogene 1 Neighboring gene monoamine oxidase B Neighboring gene AE binding protein 2, pseudogene 1 Neighboring gene quinolinate phosphoribosyltransferase, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aliphatic amine oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables flavin adenine dinucleotide binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables monoamine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables monoamine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables phenethylamine:oxygen oxidoreductase (deaminating) activity IEA
Inferred from Electronic Annotation
more info
 
enables primary amine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables primary amine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables primary amine oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables primary amine oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serotonin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables serotonin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
amine oxidase [flavin-containing] A
Names
MAO-A
monoamine oxidase type A
NP_387502.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033653.1NP_387502.1  amine oxidase [flavin-containing] A

    See identical proteins and their annotated locations for NP_387502.1

    Status: VALIDATED

    Source sequence(s)
    FM031063, FM037037, FM044630, FM098276, FM101032, FM117485, FM132632
    UniProtKB/TrEMBL
    G3V9Z3
    Related
    ENSRNOP00000063784.2, ENSRNOT00000066674.3
    Conserved Domains (1) summary
    COG1231
    Location:15463
    YobN; Monoamine oxidase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051356.1 Reference mRatBN7.2 Primary Assembly

    Range
    6032172..6098308 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)