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Maoa monoamine oxidase A [ Mus musculus (house mouse) ]

Gene ID: 17161, updated on 18-May-2023

Summary

Official Symbol
Maoaprovided by MGI
Official Full Name
monoamine oxidase Aprovided by MGI
Primary source
MGI:MGI:96915
See related
Ensembl:ENSMUSG00000025037 AllianceGenome:MGI:96915
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1110061B18Rik
Summary
Enables primary amine oxidase activity. Acts upstream of or within dopamine catabolic process and positive regulation of signal transduction. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; peripheral nervous system ganglion; and sensory organ. Used to study Brunner Syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease; Brunner Syndrome; alcohol use disorder; autism spectrum disorder; and panic disorder. Orthologous to human MAOA (monoamine oxidase A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 27.2), colon adult (RPKM 10.2) and 19 other tissues See more
Orthologs
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Genomic context

See Maoa in Genome Data Viewer
Location:
X A1.2; X 11.78 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) X NC_000086.8 (16485937..16554051)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (16619698..16687812)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Kruppel-like factor 17 pseudogene Neighboring gene casein kinase 2, alpha 1 polypeptide, pseudogene 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:16196670-16196853 Neighboring gene monoamine oxidase B Neighboring gene Norrie disease (pseudoglioma) (human)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC27811

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aliphatic amine oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables aminoacetone:oxygen oxidoreductase(deaminating) activity IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables monoamine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables phenethylamine:oxygen oxidoreductase (deaminating) activity IEA
Inferred from Electronic Annotation
more info
 
enables primary amine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables primary amine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables primary amine oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables primary amine oxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serotonin binding ISO
Inferred from Sequence Orthology
more info
 
enables tryptamine:oxygen oxidoreductase (deaminating) activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
amine oxidase [flavin-containing] A
Names
MAO-A
monoamine oxidase type A
NP_776101.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173740.3NP_776101.3  amine oxidase [flavin-containing] A

    See identical proteins and their annotated locations for NP_776101.3

    Status: VALIDATED

    Source sequence(s)
    AK146612, AK164457, BB694072
    Consensus CDS
    CCDS30033.1
    UniProtKB/Swiss-Prot
    Q64133, Q8K0Z8
    UniProtKB/TrEMBL
    Q3TPD9, Q3UJ53
    Related
    ENSMUSP00000026013.6, ENSMUST00000026013.6
    Conserved Domains (2) summary
    COG1231
    Location:15463
    YobN; Monoamine oxidase [Amino acid transport and metabolism]
    pfam13450
    Location:1884
    NAD_binding_8; NAD(P)-binding Rossmann-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    16485937..16554051
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)