U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MAOA monoamine oxidase A [ Homo sapiens (human) ]

Gene ID: 4128, updated on 1-Oct-2024

Summary

Official Symbol
MAOAprovided by HGNC
Official Full Name
monoamine oxidase Aprovided by HGNC
Primary source
HGNC:HGNC:6833
See related
Ensembl:ENSG00000189221 MIM:309850; AllianceGenome:HGNC:6833
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRNRS; MAO-A
Summary
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Expression
Broad expression in small intestine (RPKM 94.9), fat (RPKM 78.4) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MAOA in Genome Data Viewer
Location:
Xp11.3
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (43655006..43746817)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (43061181..43153033)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (43514254..43606064)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:43201432-43202228 Neighboring gene Nanog homeobox pseudogene 10 Neighboring gene MPRA-validated peak7375 silencer Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:43309398-43310202 Neighboring gene MPRA-validated peak7376 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chrX:43514055-43514449 Neighboring gene monoamine oxidase B Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:43808655-43809172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:43809173-43809689 Neighboring gene NDP antisense RNA 1 Neighboring gene norrin cystine knot growth factor NDP

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Brunner syndrome
MedGen: C0796275 OMIM: 300615 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2012-09-26)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated 2012-09-26)

ClinGen Genome Curation PagePubMed

EBI GWAS Catalog

Description
Genome-wide and candidate gene association study of cigarette smoking behaviors.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aliphatic amine oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables monoamine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables primary methylamine oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables primary methylamine oxidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biogenic amine metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in dopamine catabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion HTP PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
amine oxidase [flavin-containing] A
Names
monoamine oxidase type A
NP_000231.1
NP_001257387.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008957.2 RefSeqGene

    Range
    5139..95657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000240.4NP_000231.1  amine oxidase [flavin-containing] A isoform 1

    See identical proteins and their annotated locations for NP_000231.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL020990, BC008064, BC044787
    Consensus CDS
    CCDS14260.1
    UniProtKB/Swiss-Prot
    B4DF46, P21397, Q16426
    UniProtKB/TrEMBL
    Q53EZ0, Q53YE7
    Related
    ENSP00000340684.3, ENST00000338702.4
    Conserved Domains (1) summary
    COG1231
    Location:15460
    YobN; Monoamine oxidase [Amino acid transport and metabolism]
  2. NM_001270458.2NP_001257387.1  amine oxidase [flavin-containing] A isoform 2

    See identical proteins and their annotated locations for NP_001257387.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR and uses a downstream, in-frame start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK293926, AL020990, BC044787, BX530072
    Consensus CDS
    CCDS59163.1
    UniProtKB/Swiss-Prot
    P21397
    UniProtKB/TrEMBL
    Q49A63
    Related
    ENSP00000440846.1, ENST00000542639.6
    Conserved Domains (1) summary
    COG1231
    Location:41327
    YobN; Monoamine oxidase [Amino acid transport and metabolism]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    43655006..43746817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    43061181..43153033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)