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CD274 CD274 molecule [ Homo sapiens (human) ]

Gene ID: 29126, updated on 26-Feb-2024

Summary

Official Symbol
CD274provided by HGNC
Official Full Name
CD274 moleculeprovided by HGNC
Primary source
HGNC:HGNC:17635
See related
Ensembl:ENSG00000120217 MIM:605402; AllianceGenome:HGNC:17635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
Summary
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in appendix (RPKM 6.7), placenta (RPKM 4.5) and 23 other tissues See more
Orthologs
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Genomic context

See CD274 in Genome Data Viewer
Location:
9p24.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (5450542..5470554)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (5455669..5475674)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5450542..5470554)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene relaxin 2 Neighboring gene relaxin 1 Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene ReSE screen-validated silencer GRCh37_chr9:5418516-5418928 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:5437227-5438426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28159 Neighboring gene ring finger protein 152 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28161 Neighboring gene uncharacterized LOC124902114 Neighboring gene Sharpr-MPRA regulatory region 9164 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:5482138-5482639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28164 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28165 Neighboring gene Sharpr-MPRA regulatory region 6415 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:5501887-5502388 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:5509079-5510278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28167 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28170 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19753 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28175 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19754 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:5629427-5629927 Neighboring gene RIC1 homolog, RAB6A GEF complex partner 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28176 Neighboring gene uncharacterized LOC124902115

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does PubMed
Tat tat HIV-1 Tat-induced upregulation of PD-L1 on monocyte-derived dendritic cells involves a TNF-alpha-mediated mechanism through the TLR4 pathway PubMed
tat The N-terminal domain (residues 1-45) of HIV-1 Tat is required for the Tat-induced upregulation of PD-L1 in monocyte-derived dendritic cells PubMed
tat HIV-1 Tat upregulates the expression of PD-L1 on the surface of dendritic cells and monocyte-derived dendritic cells PubMed
tat HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC142294, MGC142296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in TRIF-dependent toll-like receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of CD8-positive, alpha-beta T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of tumor necrosis factor superfamily cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of interleukin-10 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tolerance induction to tumor cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in regulation of activated CD4-positive, alpha-beta T cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT involved_in regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
NOT is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
programmed cell death 1 ligand 1
Names
B7 homolog 1
CD274 antigen
PDCD1 ligand 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267706.2NP_001254635.1  programmed cell death 1 ligand 1 isoform b precursor

    See identical proteins and their annotated locations for NP_001254635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AI826502, AL162253, AY291313, DQ836393
    Consensus CDS
    CCDS59118.1
    UniProtKB/Swiss-Prot
    Q9NZQ7
    UniProtKB/TrEMBL
    Q0GN75
    Related
    ENSP00000370985.4, ENST00000381573.8
    Conserved Domains (2) summary
    cd00096
    Location:2429
    Ig; Ig strand A [structural motif]
    cl11960
    Location:2497
    Ig; Immunoglobulin domain
  2. NM_001314029.2NP_001300958.1  programmed cell death 1 ligand 1 isoform c precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and novel 3' UTR compared to variant 1. It encodes isoform c which is shorter than and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA399416, DB160805, DQ836393
    UniProtKB/TrEMBL
    Q0GN75
    Conserved Domains (2) summary
    smart00410
    Location:24130
    IG_like; Immunoglobulin like
    cl11960
    Location:66114
    Ig; Immunoglobulin domain
  3. NM_014143.4NP_054862.1  programmed cell death 1 ligand 1 isoform a precursor

    See identical proteins and their annotated locations for NP_054862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI826502, AK314567, AL162253
    Consensus CDS
    CCDS6464.1
    UniProtKB/Swiss-Prot
    B2RBA2, B4DU27, Q14CJ2, Q2V8D5, Q66RK1, Q6WEX4, Q9NUZ5, Q9NZQ7
    Related
    ENSP00000370989.3, ENST00000381577.4
    Conserved Domains (1) summary
    cl11960
    Location:54117
    Ig; Immunoglobulin domain

RNA

  1. NR_052005.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI826502, AL162253, AY714881, DQ836393

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    5450542..5470554
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423262.1XP_047279218.1  programmed cell death 1 ligand 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    5455669..5475674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362810.1XP_054218785.1  programmed cell death 1 ligand 1 isoform X1