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CD274 CD274 molecule [ Homo sapiens (human) ]

Gene ID: 29126, updated on 10-Dec-2019

Summary

Official Symbol
CD274provided by HGNC
Official Full Name
CD274 moleculeprovided by HGNC
Primary source
HGNC:HGNC:17635
See related
Ensembl:ENSG00000120217 MIM:605402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
Summary
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Broad expression in appendix (RPKM 6.7), placenta (RPKM 4.5) and 23 other tissues See more
Orthologs

Genomic context

See CD274 in Genome Data Viewer
Location:
9p24.1
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (5450503..5470567)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (5450503..5470567)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 31 Neighboring gene relaxin 2 Neighboring gene relaxin 1 Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene ring finger protein 152 pseudogene 1 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene RIC1 homolog, RAB6A GEF complex partner 1 Neighboring gene endoplasmic reticulum metallopeptidase 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The low mannose-level gp120 induces higher activation of plasmacytoid dendritic cells by upregulation of IFN-alpha, PD-L1, CD40, CCR7, CD80, and CD86 than the high mannose-level gp120 does PubMed
Tat tat HIV-1 Tat-induced upregulation of PD-L1 on monocyte-derived dendritic cells involves a TNF-alpha-mediated mechanism through the TLR4 pathway PubMed
tat The N-terminal domain (residues 1-45) of HIV-1 Tat is required for the Tat-induced upregulation of PD-L1 in monocyte-derived dendritic cells PubMed
tat HIV-1 Tat upregulates the expression of PD-L1 on the surface of dendritic cells and monocyte-derived dendritic cells PubMed
tat HIV-1 Tat-induced upregulation of B7-H1 protein expression requires activation of the ERK/MAPK signaling pathway in human endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
    Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
    Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
  • Costimulation by the CD28 family, organism-specific biosystem (from REACTOME)
    Costimulation by the CD28 family, organism-specific biosystemOptimal activation of T-lymphocytes requires at least two signals. A primary one is delivered by the T-cell receptor (TCR) complex after antigen recognition and additional costimulatory signals are d...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • PD-1 signaling, organism-specific biosystem (from REACTOME)
    PD-1 signaling, organism-specific biosystemThe Programmed cell death protein 1 (PD-1) is one of the negative regulators of TCR signaling. PD-1 may exert its effects on cell differentiation and survival directly by inhibiting early activation ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC142294, MGC142296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
T cell costimulation IDA
Inferred from Direct Assay
more info
PubMed 
T cell costimulation TAS
Traceable Author Statement
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of CD8-positive, alpha-beta T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor superfamily cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of T cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of interleukin-10 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of tolerance induction to tumor cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT regulation of activated CD4-positive, alpha-beta T cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cytokine IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
toxin transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
programmed cell death 1 ligand 1
Names
B7 homolog 1
CD274 antigen
PDCD1 ligand 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267706.1NP_001254635.1  programmed cell death 1 ligand 1 isoform b

    See identical proteins and their annotated locations for NP_001254635.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AI826502, AL135786, AL162253, AY291313, DQ836393
    Consensus CDS
    CCDS59118.1
    UniProtKB/Swiss-Prot
    Q9NZQ7
    UniProtKB/TrEMBL
    Q0GN75
    Related
    ENSP00000370985.4, ENST00000381573.8
    Conserved Domains (1) summary
    cl11960
    Location:21106
    Ig; Immunoglobulin domain
  2. NM_001314029.2NP_001300958.1  programmed cell death 1 ligand 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks several exons and its 3' terminal exon extends past a splice site that is used in variant 1. This results in a novel 3' coding region and novel 3' UTR compared to variant 1. It encodes isoform c which is shorter than and has a distinct C-terminus compared to isoform a.
    Source sequence(s)
    AA399416, DB160805, DQ836393
    UniProtKB/TrEMBL
    Q0GN75
    Conserved Domains (2) summary
    smart00410
    Location:24130
    IG_like; Immunoglobulin like
    cl11960
    Location:66114
    Ig; Immunoglobulin domain
  3. NM_014143.4NP_054862.1  programmed cell death 1 ligand 1 isoform a precursor

    See identical proteins and their annotated locations for NP_054862.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AI826502, AK314567, AL162253
    Consensus CDS
    CCDS6464.1
    UniProtKB/Swiss-Prot
    Q9NZQ7
    Related
    ENSP00000370989.3, ENST00000381577.4
    Conserved Domains (1) summary
    cl11960
    Location:54117
    Ig; Immunoglobulin domain

RNA

  1. NR_052005.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI826502, AL162253, AY714881, DQ836393

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    5450503..5470567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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