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Cd274 CD274 antigen [ Mus musculus (house mouse) ]

Gene ID: 60533, updated on 28-Nov-2021

Summary

Official Symbol
Cd274provided by MGI
Official Full Name
CD274 antigenprovided by MGI
Primary source
MGI:MGI:1926446
See related
Ensembl:ENSMUSG00000016496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik
Summary
The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis. [provided by RefSeq, Sep 2015]
Expression
Broad expression in thymus adult (RPKM 7.4), mammary gland adult (RPKM 5.3) and 23 other tissues See more
Orthologs
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Genomic context

See Cd274 in Genome Data Viewer
Location:
19; 19 C1
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (29339428..29365495)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (29362107..29388095)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (29441928..29462585)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52390 Neighboring gene relaxin 1 Neighboring gene plasminogen receptor, C-terminal lysine transmembrane protein Neighboring gene predicted gene, 36043 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene RIKEN cDNA A930007I19 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell costimulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in T cell costimulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell surface receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of CD8-positive, alpha-beta T cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of T cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor superfamily cytokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-10 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tolerance induction to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cytokine ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within toxin transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
programmed cell death 1 ligand 1
Names
B7 homolog 1
PDCD1 ligand 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021893.3NP_068693.1  programmed cell death 1 ligand 1 precursor

    See identical proteins and their annotated locations for NP_068693.1

    Status: REVIEWED

    Source sequence(s)
    AC119228, AF317088, AI645624, BY193530
    Consensus CDS
    CCDS29735.1
    UniProtKB/Swiss-Prot
    Q9EP73
    UniProtKB/TrEMBL
    Q3U472
    Related
    ENSMUSP00000016640.8, ENSMUST00000016640.8
    Conserved Domains (2) summary
    smart00409
    Location:151225
    IG; Immunoglobulin
    cl11960
    Location:40117
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    29339428..29365495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251020.2XP_030106880.1  programmed cell death 1 ligand 1 isoform X1

    Conserved Domains (2) summary
    smart00409
    Location:151225
    IG; Immunoglobulin
    cl11960
    Location:40117
    Ig; Immunoglobulin domain
  2. XM_030251021.2XP_030106881.1  programmed cell death 1 ligand 1 isoform X2

    Conserved Domains (2) summary
    smart00409
    Location:114188
    IG; Immunoglobulin
    cl11960
    Location:380
    Ig; Immunoglobulin domain
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