GRIN2A glutamate ionotropic receptor NMDA type subunit 2A [ Homo sapiens (human) ]

Gene ID: 2903, updated on 3-May-2025

Summary

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Official Symbol: GRIN2Aprovided by HGNC
Official Full Name: glutamate ionotropic receptor NMDA type subunit 2Aprovided by HGNC
Primary source: HGNC:HGNC:4585
See related: Ensembl:ENSG00000183454 MIM:138253; AllianceGenome:HGNC:4585
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LKS; EPND; FESD; NR2A; GluN2A; NMDAR2A
Summary: This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Expression: Biased expression in brain (RPKM 9.5), heart (RPKM 0.9) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

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See GRIN2A in Genome Data Viewer

Location:: 16p13.2

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (9753404..10182908, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (9786917..10217640, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (9847261..10276765, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology.
Title: Disease-Associated Variants in GRIN1, GRIN2A and GRIN2B genes: Insights into NMDA Receptor Structure, Function, and Pathophysiology.
De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
Title: De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.
Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer's Disease.
Title: Dual Role of NMDAR Containing NR2A and NR2B Subunits in Alzheimer's Disease.
METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Title: METTL14-mediated m6A epitranscriptomic modification contributes to chemotherapy-induced neuropathic pain by stabilizing GluN2A expression via IGF2BP2.
Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders.
Title: Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders.
Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids.
Title: Disease-associated nonsense and frame-shift variants resulting in the truncation of the GluN2A or GluN2B C-terminal domain decrease NMDAR surface expression and reduce potentiating effects of neurosteroids.
GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.
Title: GRIN2A (NR2A): a gene contributing to glutamatergic involvement in schizophrenia.
Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening.
Title: Functional effects of disease-associated variants reveal that the S1-M1 linker of the NMDA receptor critically controls channel opening.
Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants.
Title: Children with Early-Onset Psychosis Have Increased Burden of Rare GRIN2A Variants.
GRIN2A-related epilepsy and speech disorders: A comprehensive overview with a focus on the role of precision therapeutics.
Title: GRIN2A-related epilepsy and speech disorders: A comprehensive overview with a focus on the role of precision therapeutics.

Submit: New GeneRIF Correction See all GeneRIFs (123)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Landau-Kleffner syndrome MedGen: C0282512 OMIM: 245570 GeneReviews: GRIN2A-Related Disorders	Compare labs

Copy number response

Description
Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2024-09-25) ClinGen Genome Curation PagePubMed Triplosensitivity No evidence available (Last evaluated 2024-09-25) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide association study with DNA pooling identifies the variant rs11866328 in the GRIN2A gene that affects disease progression of chronic HBV infection. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. EBI GWAS Catalog EBI GWAS CatalogPubMed
Biological insights from 108 schizophrenia-associated genetic loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
Common genetic variation and the control of HIV-1 in humans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies three susceptibility loci for laryngeal squamous cell carcinoma in the Chinese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin	PubMed
	env	HIV-1 gp120 activates forward trafficking and surface clustering of NMDA receptors in membrane microdomains by a PKA-dependent phosphorylation of the NR1 C-terminal Ser897, followed by a PKC-dependent phosphorylation of Ser896	PubMed
	env	HIV-1 gp120-induced synapse loss requires sequential activation of CXCR4, IL-1beta receptor, and NMDA receptor	PubMed
	env	HIV-1 gp120 activates NMDA receptor directly and phosphorylates JNK through a gp120-mediated apoptotic pathway in human neuroblastoma cells	PubMed
	env	HIV-1 clade B gp120 significantly downregulates NMDA receptor gene and protein expression and levels of glutamine compared to clade C gp120	PubMed
	env	HIV-1 gp120-mediated human cell death involves the NMDA receptor complex; antagonists of the NMDA receptor reverse the gp120-mediated effects	PubMed
	env	HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor	PubMed
	env	HIV-1 gp120 binds to cells expressing epsilon1/zeta1 or epsilon2/zeta1 combined NMDA receptor subunits, but not to cells expressing a single epsilon1, epsilon2, or zeta1 NMDA receptor subunit	PubMed
Tat	tat	Ca(2+) influx through the NMDA receptor is necessary for HIV-1 Tat-induced synapse loss	PubMed
	tat	HIV-1 Tat increases in inhibitory synapse number in neurons are dependent on LRP binding and GluN2A-containing NMDAR activation but not PSD95 ubiquitination	PubMed
	tat	HIV-1 Tat upregulates the expression of NMDARs for the apoptosis of retinal pigmen epithelium (RPE) cells. Silencing of NMDARs by siRNA abolishes Tat-induced RPE apoptosis	PubMed
	tat	HIV-1 Tat-induced activation of spermine oxidase (SMO) activity involves NMDAR stimulation in human neuroblastoma	PubMed
	tat	HIV-1 Tat and methamphetamine inhibit the normal conjunction of signaling between D1 and NMDA receptors, resulting in neural dysfunction and death	PubMed
	tat	HIV-1 Tat interacts with NMDA receptors in primary neuronal-glial cultures and in hippocampal slice cultures	PubMed
	tat	HIV-1 Tat treatment induces the formation of complexes involving the low-density lipoprotein receptor-related protein (LRP), postsynaptic density protein-95 (PSD-95), and N-methyl-d-aspartic acid (NMDA) receptors at the neuron surface	PubMed
	tat	Tat treatment causes activation of neuronal nitric oxide synthase (nNOS) through association with NMDA receptors	PubMed
	tat	HIV-1 Tat treatment of human neurons results in tyrosine (Y) phosphorylation at position 1325 of the NMDAR subunit 2A (NR2A) in a src kinase-dependent manner	PubMed
	tat	HIV-1 Tat treatment of primary differentiated human neurons induces extensive apoptosis through increased amounts of NMDAR2A expression, but only low levels of apoptosis in primary immature human neurons result from low or minimal expression of NMDAR2A	PubMed
	tat	HIV-1 Tat-induced NMDA receptor activation is clade dependent. The Cys 30-Cys 31 motif in Tat is critical for the NMDA receptor activation	PubMed
	tat	HIV-1 Tat induces apoptosis of neurons and neurotoxicity through the activation of both NMDA and non-NMDA receptors	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-149675 (e-PCR)
- UniSTS:177157

D16S3126 (e-PCR)
- UniSTS:28448

D16S2596E (e-PCR)
- UniSTS:19233

D16S2952 (e-PCR)
- UniSTS:61483

G01525 (e-PCR)
- UniSTS:45101

GRIN2A_118 (e-PCR)
- UniSTS:277296

D16S3187 (e-PCR)
- UniSTS:83252

RH69953 (e-PCR)
- UniSTS:56126

G10721 (e-PCR)
- UniSTS:65875

RH91712 (e-PCR)
- UniSTS:86107

D16S2599E (e-PCR)
- UniSTS:151667

D16S2608E (e-PCR)
- UniSTS:151676

D16S407 (e-PCR), detects polymorphism
- UniSTS:37252

RH15641 (e-PCR)
- UniSTS:35717

D16S407 (e-PCR), detects polymorphism
- UniSTS:38533

D16S3064 (e-PCR)
- UniSTS:2188

RH98186 (e-PCR)
- UniSTS:85660

Grin2a (e-PCR), detects polymorphism
- UniSTS:143261

D16S407 (e-PCR), detects polymorphism
- UniSTS:57503

SHGC-83077 (e-PCR)
- UniSTS:101305

SHGC-18386 (e-PCR)
- UniSTS:2749

RH15627 (e-PCR)
- UniSTS:83136

SHGC-12942 (e-PCR)
- UniSTS:56536

D16S732 (e-PCR)
- UniSTS:27113

SHGC-111612 (e-PCR)
- UniSTS:168431

D16S3229 (e-PCR)
- UniSTS:73210

G17910 (e-PCR)
- UniSTS:44284

GRIN2A (e-PCR)
- UniSTS:480253

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NMDA glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables NMDA glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables NMDA glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables NMDA glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables NMDA glutamate receptor activity	TAS Traceable Author Statement more info	PubMed
enables amyloid-beta binding	TAS Traceable Author Statement more info	PubMed
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables glutamate-gated calcium ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated calcium ion channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in brain development	NAS Non-traceable Author Statement more info	PubMed
involved_in calcium ion transmembrane import into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane import into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
NOT involved_in cellular response to amyloid-beta	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within directional locomotion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dopamine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in excitatory chemical synaptic transmission	NAS Non-traceable Author Statement more info	PubMed
involved_in excitatory postsynaptic potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
involved_in glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in glutamate receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within learning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within learning or memory	IEA Inferred from Electronic Annotation more info
involved_in learning or memory	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within locomotion	IEA Inferred from Electronic Annotation more info
involved_in long-term synaptic potentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within long-term synaptic potentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within memory	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in monoatomic cation transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neurogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of excitatory postsynaptic potential	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein localization to postsynaptic membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of neuronal synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of synaptic plasticity	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within response to amphetamine	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to ethanol	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to wounding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sensory perception of pain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within serotonin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sleep	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within startle response	IEA Inferred from Electronic Annotation more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within visual learning	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of NMDA selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NMDA selective glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of NMDA selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of NMDA selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
part_of NMDA selective glutamate receptor complex	ISS Inferred from Sequence or Structural Similarity more info
part_of NMDA selective glutamate receptor complex	TAS Traceable Author Statement more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuron projection	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
located_in postsynapse	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic membrane	NAS Non-traceable Author Statement more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synaptic vesicle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamate receptor ionotropic, NMDA 2A

Names: N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; glutamate ionotropic receptor NMDA 2A; glutamate receptor, ionotropic, N-methyl D-aspartate 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_011812.2 RefSeqGene

Range

5327..434347

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000833.5 → NP_000824.1 glutamate receptor ionotropic, NMDA 2A isoform 1 precursor

See identical proteins and their annotated locations for NP_000824.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Transcript variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AC006531, AC007218, AC022168, U09002, U90277

Consensus CDS

CCDS10539.1

UniProtKB/Swiss-Prot

O00669, Q12879, Q17RZ6

UniProtKB/TrEMBL

Q547U9, Q59EW6

Related

ENSP00000379818.2, ENST00000396573.6

Conserved Domains (5) summary

cd06378
Location:32 → 392

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

COG0834
Location:458 → 541

HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]

cd13718
Location:403 → 802

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:556 → 828

Lig_chan; Ligand-gated ion channel

pfam10565
Location:839 → 1464

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
NM_001134407.3 → NP_001127879.1 glutamate receptor ionotropic, NMDA 2A isoform 1 precursor

See identical proteins and their annotated locations for NP_001127879.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. Transcript variants 1 and 2 encode the same isoform (1).

Source sequence(s)

AB209695, AC006531, AC007218, AC022168, U09002

Consensus CDS

CCDS10539.1

UniProtKB/Swiss-Prot

O00669, Q12879, Q17RZ6

UniProtKB/TrEMBL

Q547U9, Q59EW6

Related

ENSP00000332549.3, ENST00000330684.4

Conserved Domains (5) summary

cd06378
Location:32 → 392

PBP1_iGluR_NMDA_NR2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

COG0834
Location:458 → 541

HisJ; ABC-type amino acid transport/signal transduction system, periplasmic component/domain [Amino acid transport and metabolism, Signal transduction mechanisms]

cd13718
Location:403 → 802

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

pfam00060
Location:556 → 828

Lig_chan; Ligand-gated ion channel

pfam10565
Location:839 → 1464

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus
NM_001134408.2 → NP_001127880.1 glutamate receptor ionotropic, NMDA 2A isoform 2 precursor

See identical proteins and their annotated locations for NP_001127880.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) has a shorter 5' UTR and is alternatively spliced at the 3' end, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC007218, BC143273, U90277

Consensus CDS

CCDS45407.1

UniProtKB/TrEMBL

A0A890YTL4, F5GZ52

Related

ENSP00000454998.1, ENST00000562109.5

Conserved Domains (3) summary

cd13718
Location:403 → 802

PBP2_iGluR_NMDA_Nr2; The ligand-binding domain of the NR2 subunit of ionotropic NMDA (N-methyl-D-aspartate) glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily

cd06378
Location:32 → 387

PBP1_iGluR_NMDA_NR2; N-terminal leucine-isoleucine-valine-binding protein (LIVBP)-like domain of the NR2 subunit of NMDA receptor family

pfam10565
Location:839 → 1258

NMDAR2_C; N-methyl D-aspartate receptor 2B3 C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

9753404..10182908 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047433994.1 → XP_047289950.1 glutamate receptor ionotropic, NMDA 2A isoform X4

UniProtKB/TrEMBL

A0A890YTL4, F5GZ52
XM_017023173.2 → XP_016878662.1 glutamate receptor ionotropic, NMDA 2A isoform X3

UniProtKB/TrEMBL

F5GZ52

Related

ENSP00000441572.3, ENST00000535259.6
XM_047433993.1 → XP_047289949.1 glutamate receptor ionotropic, NMDA 2A isoform X2

UniProtKB/Swiss-Prot

O00669, Q12879, Q17RZ6

UniProtKB/TrEMBL

Q547U9, Q59EW6
XM_017023172.2 → XP_016878661.1 glutamate receptor ionotropic, NMDA 2A isoform X1

UniProtKB/TrEMBL

Q59EW6

Related

ENSP00000502200.1, ENST00000674742.1

Alternate T2T-CHM13v2.0

Genomic

NC_060940.1 Alternate T2T-CHM13v2.0

Range

9786917..10217640 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054380151.1 → XP_054236126.1 glutamate receptor ionotropic, NMDA 2A isoform X4

UniProtKB/TrEMBL

A0A890YTL4, F5GZ52
XM_054380150.1 → XP_054236125.1 glutamate receptor ionotropic, NMDA 2A isoform X3

UniProtKB/TrEMBL

F5GZ52
XM_054380149.1 → XP_054236124.1 glutamate receptor ionotropic, NMDA 2A isoform X2

UniProtKB/Swiss-Prot

O00669, Q12879, Q17RZ6

UniProtKB/TrEMBL

Q547U9, Q59EW6
XM_054380148.1 → XP_054236123.1 glutamate receptor ionotropic, NMDA 2A isoform X1

UniProtKB/TrEMBL

Q59EW6