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MKNK2 MAP kinase interacting serine/threonine kinase 2 [ Homo sapiens (human) ]

Gene ID: 2872, updated on 8-Dec-2018

Summary

Official Symbol
MKNK2provided by HGNC
Official Full Name
MAP kinase interacting serine/threonine kinase 2provided by HGNC
Primary source
HGNC:HGNC:7111
See related
Ensembl:ENSG00000099875 MIM:605069
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MNK2; GPRK7
Summary
This gene encodes a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, which belongs to the protein kinase superfamily. This protein contains conserved DLG (asp-leu-gly) and ENIL (glu-asn-ile-leu) motifs, and an N-terminal polybasic region which binds importin A and the translation factor scaffold protein eukaryotic initiation factor 4G (eIF4G). This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined. These two variants encode distinct isoforms which differ in activity and regulation, and in subcellular localization. [provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in esophagus (RPKM 52.7), bone marrow (RPKM 47.1) and 25 other tissues See more
Orthologs

Genomic context

See MKNK2 in Genome Data Viewer
Location:
19p13.3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (2037471..2051278, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2037470..2051243, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene BTB domain containing 2 Neighboring gene uncharacterized LOC107985278 Neighboring gene MOB kinase activator 3A Neighboring gene IZUMO family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr downregulates expression of genes involved in the MEK2-ERK pathway, including MAP2K2 (MEK2) and MKNK2, and overexpression of Vpr decreases phosphorylation of MEK2 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression, organism-specific biosystem (from WikiPathways)
    4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression, organism-specific biosystemThis pathway is modeled after Figure 7 in the article ''Upstream molecular signaling pathways of p27(Kip1) expression: effects of 4-hydroxytamoxifen, dexamethasone, and retinoic acids'' (See Bibliogr...
  • HIF-1 signaling pathway, organism-specific biosystem (from KEGG)
    HIF-1 signaling pathway, organism-specific biosystemHypoxia-inducible factor 1 (HIF-1) is a transcription factor that functions as a master regulator of oxygen homeostasis. It consists of two subunits: an inducibly-expressed HIF-1alpha subunit and a c...
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystem (from WikiPathways)
    Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystemPathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the litera...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
cellular response to arsenic-containing substance IDA
Inferred from Direct Assay
more info
PubMed 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
hemopoiesis IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 2
Names
G protein-coupled receptor kinase 7
MAP kinase signal-integrating kinase 2
MAPK signal-integrating kinase 2
NP_060042.2
NP_951009.1
XP_024307239.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029798.1 RefSeqGene

    Range
    5001..18774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_017572.3NP_060042.2  MAP kinase-interacting serine/threonine-protein kinase 2 isoform 1

    See identical proteins and their annotated locations for NP_060042.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 3' exon including 3' coding region and 3' UTR, compared to variant 2. The resulting protein (isoform 1, also known as isoform b) has a shorter and distinct C-terminus, compared to isoform 2. This isoform is found in the nucleus and lacks the MAP kinase-binding region.
    Source sequence(s)
    AL137615, BC073140, DA950743
    Consensus CDS
    CCDS12079.1
    UniProtKB/Swiss-Prot
    Q9HBH9
    Related
    ENSP00000309485.6, ENST00000309340.11
    Conserved Domains (2) summary
    smart00220
    Location:83368
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14173
    Location:81368
    STKc_Mnk2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2
  2. NM_199054.2NP_951009.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform 2

    See identical proteins and their annotated locations for NP_951009.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is the longer transcript and it encodes the longer protein (isoform 2, also known as isoform a), which is located in the cytoplasm and has an MAP kinase-binding region at the C-terminus.
    Source sequence(s)
    AK092536, AL137615, BC073140, DA950743
    Consensus CDS
    CCDS12080.1
    UniProtKB/Swiss-Prot
    Q9HBH9
    UniProtKB/TrEMBL
    B3KS07
    Related
    ENSP00000250896.3, ENST00000250896.7
    Conserved Domains (2) summary
    smart00220
    Location:83368
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14173
    Location:81368
    STKc_Mnk2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    2037471..2051278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451471.1XP_024307239.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1

    Conserved Domains (1) summary
    cd14173
    Location:126413
    STKc_Mnk2; Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2
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