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Mknk2 MAP kinase-interacting serine/threonine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 17347, updated on 12-May-2024

Summary

Official Symbol
Mknk2provided by MGI
Official Full Name
MAP kinase-interacting serine/threonine kinase 2provided by MGI
Primary source
MGI:MGI:894279
See related
Ensembl:ENSMUSG00000020190 AllianceGenome:MGI:894279
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mnk2; Gprk7; 2010016G11Rik
Summary
The protein encoded by this gene is a serine/threonine-protein kinase, which is targeted by both the extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways. This enzyme targets several substrates including eukaryotic translation initiation factor 4E and mammalian target of rapamycin, which are negatively regulated by its phosphorylation. Null mutant mice do not exhibit developmental or reproductive defects. However, mice null for both this protein and mitogen-activated protein kinase-interacting serine/threonine protein kinase 1 have delayed tumor development in phosphatase and tensin homolog mutant mice, indicating an oncogenic function for this gene in tumor development. [provided by RefSeq, Oct 2014]
Expression
Broad expression in mammary gland adult (RPKM 326.2), subcutaneous fat pad adult (RPKM 252.6) and 25 other tissues See more
Orthologs
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Genomic context

See Mknk2 in Genome Data Viewer
Location:
10 C1; 10 39.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (80501152..80512264, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (80665318..80676293, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene casein kinase 1, gamma 2 Neighboring gene predicted gene, 51810 Neighboring gene BTB domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E3899 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:80141015-80141203 Neighboring gene MOB kinase activator 3A Neighboring gene STARR-positive B cell enhancer ABC_E6884 Neighboring gene IZUMO family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
MAP kinase-interacting serine/threonine-protein kinase 2
Names
G protein-coupled receptor kinase 7
MAP kinase signal-integrating kinase 2
NP_067437.2
XP_006513379.1
XP_017169313.1
XP_036011555.1
XP_036011556.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001428628.1NP_001415557.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC152410
    UniProtKB/Swiss-Prot
    O08606, Q75PY0, Q8CDB0, Q9D893
  2. NM_001428629.1NP_001415558.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 4, encodes isoform b.
    Source sequence(s)
    AC152410
    UniProtKB/TrEMBL
    A0A0R4IZX7
  3. NM_001428630.1NP_001415559.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC152410
    UniProtKB/TrEMBL
    A0A0R4IZX7
  4. NM_021462.5NP_067437.2  MAP kinase-interacting serine/threonine-protein kinase 2 isoform a

    See identical proteins and their annotated locations for NP_067437.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).
    Source sequence(s)
    AC152410
    Consensus CDS
    CCDS24030.2
    UniProtKB/Swiss-Prot
    O08606, Q75PY0, Q8CDB0, Q9D893
    Related
    ENSMUSP00000143508.2, ENSMUST00000200082.5
    Conserved Domains (1) summary
    cl21453
    Location:81368
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    80501152..80512264 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513316.3XP_006513379.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1

    Conserved Domains (1) summary
    cl21453
    Location:81368
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036155662.1XP_036011555.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

    Related
    ENSMUSP00000003433.7, ENSMUST00000003433.11
    Conserved Domains (1) summary
    cl21453
    Location:34321
    PKc_like; Protein Kinases, catalytic domain
  3. XM_036155663.1XP_036011556.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0R4IZX7
    Conserved Domains (1) summary
    cl21453
    Location:34321
    PKc_like; Protein Kinases, catalytic domain
  4. XM_017313824.3XP_017169313.1  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:34321
    PKc_like; Protein Kinases, catalytic domain