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ZNF875 zinc finger protein 875 [ Homo sapiens (human) ]

Gene ID: 284459, updated on 13-Aug-2020

Summary

Official Symbol
ZNF875provided by HGNC
Official Full Name
zinc finger protein 875provided by HGNC
Primary source
HGNC:HGNC:4928
See related
Ensembl:ENSG00000181666 MIM:165250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HKR1
Expression
Ubiquitous expression in prostate (RPKM 5.1), thyroid (RPKM 4.9) and 25 other tissues See more
Orthologs

Genomic context

See ZNF875 in Genome Data Viewer
Location:
19q13.12
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (37312837..37364455)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37825580..37855357)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1535 Neighboring gene uncharacterized LOC284412 Neighboring gene zinc finger protein 527 Neighboring gene zinc finger protein 569 Neighboring gene zinc finger protein 570

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41385

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
multicellular organism development NAS
Non-traceable Author Statement
more info
PubMed 
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 875
Names
HKR1, GLI-Kruppel zinc finger family member
Krueppel-related zinc finger protein 1
oncogene HKR1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001329761.1NP_001316690.1  zinc finger protein 875 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 3, encodes isoform b.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82337.1
    UniProtKB/TrEMBL
    K7EPW3
    Related
    ENSP00000467562.1, ENST00000589392.5
  2. NM_001329762.2NP_001316691.1  zinc finger protein 875 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82337.1
    UniProtKB/TrEMBL
    K7EPW3
  3. NM_001329763.1NP_001316692.1  zinc finger protein 875 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform c.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82338.1
    UniProtKB/Swiss-Prot
    P10072
    Conserved Domains (3) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:280639
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368388
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001329764.1NP_001316693.1  zinc finger protein 875 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform c.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82338.1
    UniProtKB/Swiss-Prot
    P10072
    Conserved Domains (3) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:280639
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368388
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001329765.1NP_001316694.1  zinc finger protein 875 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform d.
    Source sequence(s)
    AC008806, AC016590
  6. NM_001329766.1NP_001316695.1  zinc finger protein 875 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform d.
    Source sequence(s)
    AC008806, AC016590
  7. NM_001329767.2NP_001316696.1  zinc finger protein 875 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  8. NM_001329768.2NP_001316697.1  zinc finger protein 875 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  9. NM_001329769.1NP_001316698.1  zinc finger protein 875 isoform g

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  10. NM_001329770.1NP_001316699.1  zinc finger protein 875 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  11. NM_001329771.1NP_001316700.1  zinc finger protein 875 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform i.
    Source sequence(s)
    AC008806, AC016590
  12. NM_001329772.1NP_001316701.1  zinc finger protein 875 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform i.
    Source sequence(s)
    AC008806, AC016590
  13. NM_001329773.1NP_001316702.1  zinc finger protein 875 isoform i

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform i.
    Source sequence(s)
    AC008806, AC016590
  14. NM_001329774.2NP_001316703.1  zinc finger protein 875 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 16-19, encodes isoform j.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82339.1
    UniProtKB/TrEMBL
    Q7Z6E1
    Conserved Domains (4) summary
    COG5048
    Location:238597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:574596
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422447
    zf-H2C2_2; Zinc-finger double domain
  15. NM_001329775.2NP_001316704.1  zinc finger protein 875 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 15 and 17-19, encodes isoform j.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82339.1
    UniProtKB/TrEMBL
    Q7Z6E1
    Conserved Domains (4) summary
    COG5048
    Location:238597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:574596
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422447
    zf-H2C2_2; Zinc-finger double domain
  16. NM_001329776.1NP_001316705.1  zinc finger protein 875 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 15, 16, 18, and 19, encodes isoform j.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82339.1
    UniProtKB/TrEMBL
    Q7Z6E1
    Conserved Domains (4) summary
    COG5048
    Location:238597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:574596
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422447
    zf-H2C2_2; Zinc-finger double domain
  17. NM_001329777.2NP_001316706.1  zinc finger protein 875 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 15-17 and 19, encodes isoform j.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82339.1
    UniProtKB/TrEMBL
    Q7Z6E1
    Conserved Domains (4) summary
    COG5048
    Location:238597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:574596
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422447
    zf-H2C2_2; Zinc-finger double domain
  18. NM_001329778.1NP_001316707.1  zinc finger protein 875 isoform j

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 15-18, encodes isoform j.
    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82339.1
    UniProtKB/TrEMBL
    Q7Z6E1
    Conserved Domains (4) summary
    COG5048
    Location:238597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:574596
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422447
    zf-H2C2_2; Zinc-finger double domain
  19. NM_001329779.2NP_001316708.1  zinc finger protein 875 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  20. NM_001353803.1NP_001340732.1  zinc finger protein 875 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
    Consensus CDS
    CCDS82338.1
    Related
    ENSP00000375994.3, ENST00000392153.7
    Conserved Domains (3) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:280639
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:368388
    ZF_C2H2; C2H2 Zn finger [structural motif]
  21. NM_001353804.2NP_001340733.1  zinc finger protein 875 isoform l

    Status: VALIDATED

    Description
    Transcript Variant: This variant (50) lacks an exon in the 5' region and differs in the 3' coding region and 3' UTR compared to variant 1. The encoded isoform (l) differs in the N- and C-termini compared to isoform a.
    Source sequence(s)
    BC010024, DC362408
    Consensus CDS
    CCDS86758.1
    Related
    ENSP00000466472.1, ENST00000591259.5
    Conserved Domains (1) summary
    smart00349
    Location:1473
    KRAB; krueppel associated box
  22. NM_181786.3NP_861451.1  zinc finger protein 875 isoform a

    See identical proteins and their annotated locations for NP_861451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC017256, DC362408
    Consensus CDS
    CCDS12502.1
    UniProtKB/Swiss-Prot
    P10072
    Related
    ENSP00000315505.3, ENST00000324411.8
    Conserved Domains (3) summary
    smart00349
    Location:3392
    KRAB; krueppel associated box
    COG5048
    Location:299658
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:387407
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_138103.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016590, AK128116, BC017256
  2. NR_138104.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  3. NR_138105.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  4. NR_138106.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  5. NR_138107.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  6. NR_138108.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  7. NR_138109.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
    Related
    ENST00000652615.1
  8. NR_138110.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  9. NR_138111.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  10. NR_138112.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  11. NR_138113.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  12. NR_138114.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  13. NR_138115.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  14. NR_138116.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  15. NR_138117.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  16. NR_138118.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  17. NR_138119.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  18. NR_138120.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  19. NR_138121.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  20. NR_138122.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  21. NR_138123.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  22. NR_138124.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  23. NR_138125.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  24. NR_138126.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  25. NR_138127.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  26. NR_138128.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  27. NR_138129.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  28. NR_138130.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC008806, AC016590
  29. NR_148546.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (51) lacks the open reading frame found in coding variants and contains an alternate 3' exon structure.
    Source sequence(s)
    AC016590

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    37312837..37364455
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026702.2XP_016882191.1  zinc finger protein 875 isoform X6

    UniProtKB/TrEMBL
    F5H6A5
    Related
    ENSP00000437774.1, ENST00000544914.5
    Conserved Domains (2) summary
    COG5048
    Location:26385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114134
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_017026674.1XP_016882163.1  zinc finger protein 875 isoform X3

  3. XM_017026675.1XP_016882164.1  zinc finger protein 875 isoform X4

  4. XM_024451468.1XP_024307236.1  zinc finger protein 875 isoform X6

    Conserved Domains (2) summary
    COG5048
    Location:26385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114134
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. XM_024451469.1XP_024307237.1  zinc finger protein 875 isoform X6

    Related
    ENSP00000466467.1, ENST00000591471.5
    Conserved Domains (2) summary
    COG5048
    Location:26385
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:114134
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. XM_017026673.1XP_016882162.1  zinc finger protein 875 isoform X2

  7. XM_017026672.1XP_016882161.1  zinc finger protein 875 isoform X1

  8. XM_017026688.2XP_016882177.1  zinc finger protein 875 isoform X5

    UniProtKB/TrEMBL
    Q7Z6E1
    Related
    ENSP00000438261.1, ENST00000541583.6
    Conserved Domains (4) summary
    COG5048
    Location:238597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:326346
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:574596
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:422447
    zf-H2C2_2; Zinc-finger double domain
  9. XM_024451470.1XP_024307238.1  zinc finger protein 875 isoform X7

    Conserved Domains (3) summary
    smart00349
    Location:3392
    KRAB; krueppel associated box
    COG5048
    Location:299658
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:387407
    ZF_C2H2; C2H2 Zn finger [structural motif]
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