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ZNF841 zinc finger protein 841 [ Homo sapiens (human) ]

Gene ID: 284371, updated on 24-Nov-2020

Summary

Official Symbol
ZNF841provided by HGNC
Official Full Name
zinc finger protein 841provided by HGNC
Primary source
HGNC:HGNC:27611
See related
Ensembl:ENSG00000197608
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in prostate (RPKM 3.7), endometrium (RPKM 2.9) and 25 other tissues See more
Orthologs

Genomic context

See ZNF841 in Genome Data Viewer
Location:
19q13.41
Exon count:
9
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52050028..52095780, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52567719..52599021, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 614 Neighboring gene uncharacterized LOC112268244 Neighboring gene zinc finger protein 432 Neighboring gene zinc finger protein 160 pseudogene Neighboring gene zinc finger protein 616 Neighboring gene ribosomal protein L37 pseudogene 23

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136499.2NP_001129971.1  zinc finger protein 841 isoform 1

    See identical proteins and their annotated locations for NP_001129971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 3, 6, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AC011468
    Consensus CDS
    CCDS46161.1
    UniProtKB/Swiss-Prot
    Q6ZN19
    Conserved Domains (3) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:483885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001321349.2NP_001308278.1  zinc finger protein 841 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 10, encodes isoform 2.
    Source sequence(s)
    AC011468, AK131409
    Consensus CDS
    CCDS82388.1
    UniProtKB/Swiss-Prot
    Q6ZN19
    Related
    ENSP00000415453.2, ENST00000426391.6
    Conserved Domains (2) summary
    COG5048
    Location:367769
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343363
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001352298.2NP_001339227.1  zinc finger protein 841 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 6, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AC011468, AK131409, CN283320
    Consensus CDS
    CCDS46161.1
    Conserved Domains (3) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:483885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001352299.2NP_001339228.1  zinc finger protein 841 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC011468, BF512443, CN283320, DB333163
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:342755
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:752776
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001369825.1NP_001356754.1  zinc finger protein 841 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (4).
    Source sequence(s)
    AC011468
    Conserved Domains (3) summary
    smart00349
    Location:869
    KRAB; krueppel associated box
    COG5048
    Location:484886
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001369826.1NP_001356755.1  zinc finger protein 841 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 3, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AC011468
    Related
    ENSP00000374185.4, ENST00000389534.8
    Conserved Domains (3) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:483885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001369827.1NP_001356756.1  zinc finger protein 841 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 3, 6, and 8, encodes isoform 1.
    Source sequence(s)
    AC011468
    Conserved Domains (3) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:483885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001369828.1NP_001356757.1  zinc finger protein 841 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 3, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AC011468
    Related
    ENSP00000470746.1, ENST00000594295.5
    Conserved Domains (3) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:483885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001369829.2NP_001356758.1  zinc finger protein 841 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC011468
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:342755
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:752776
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001369830.1NP_001356759.1  zinc finger protein 841 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC011468
    Conserved Domains (2) summary
    COG5048
    Location:367769
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343363
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52050028..52095780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451465.1XP_024307233.1  zinc finger protein 841 isoform X3

    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:342755
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:752776
    zf-H2C2_2; Zinc-finger double domain
  2. XM_024451464.1XP_024307232.1  zinc finger protein 841 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:869
    KRAB; krueppel associated box
    COG5048
    Location:343756
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:753777
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026653.1XP_016882142.1  zinc finger protein 841 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:869
    KRAB; krueppel associated box
    COG5048
    Location:484886
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460480
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. XR_002958303.1 RNA Sequence

  2. XR_002958301.1 RNA Sequence

  3. XR_002958302.1 RNA Sequence

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