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ZNF841 zinc finger protein 841 [ Homo sapiens (human) ]

Gene ID: 284371, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF841provided by HGNC
Official Full Name
zinc finger protein 841provided by HGNC
Primary source
HGNC:HGNC:27611
See related
Ensembl:ENSG00000197608 AllianceGenome:HGNC:27611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in prostate (RPKM 3.7), endometrium (RPKM 2.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF841 in Genome Data Viewer
Location:
19q13.41
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (52058095..52095765, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (55145315..55182977, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (52561348..52599018, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 614 Neighboring gene uncharacterized LOC112268244 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:52530119-52530889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15034 Neighboring gene zinc finger protein 432 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15035 Neighboring gene zinc finger protein 160 pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52568267-52569466 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr19:52573383-52574582 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_51593 Neighboring gene zinc finger protein 616 Neighboring gene uncharacterized LOC124904799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15036 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10991 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10992 Neighboring gene ribosomal protein L37 pseudogene 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics. Wu AC, et al. J Allergy Clin Immunol, 2014 Mar. PMID 24280104, Free PMC Article
  2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
  3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
  5. Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease. Viard J, et al. Life Sci Alliance, 2022 Aug 1. PMID 35914814, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 841

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136499.2 → NP_001129971.1  zinc finger protein 841 isoform 1

    See identical proteins and their annotated locations for NP_001129971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variants 3, 6, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AC011468
    Consensus CDS
    CCDS46161.1
    UniProtKB/Swiss-Prot
    Q6ZN19
    Related
    ENSP00000470100.2, ENST00000594440.6
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:483 → 885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001321349.2 → NP_001308278.1  zinc finger protein 841 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variant 10, encodes isoform 2.
    Source sequence(s)
    AC011468, AK131409
    Consensus CDS
    CCDS82388.1
    UniProtKB/Swiss-Prot
    B9EG58, Q6ZN19, Q6ZN82, Q6ZP71, Q8N9U7
    Related
    ENSP00000415453.2, ENST00000426391.6
    Conserved Domains (2) summary
    COG5048
    Location:367 → 769
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001352298.2 → NP_001339227.1  zinc finger protein 841 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 1, 6, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AC011468, AK131409, CN283320
    Consensus CDS
    CCDS46161.1
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:483 → 885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001352299.2 → NP_001339228.1  zinc finger protein 841 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC011468, BF512443, CN283320, DB333163
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:342 → 755
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:752 → 776
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001369825.1 → NP_001356754.1  zinc finger protein 841 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (4).
    Source sequence(s)
    AC011468
    Conserved Domains (3) summary
    smart00349
    Location:8 → 69
    KRAB; krueppel associated box
    COG5048
    Location:484 → 886
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460 → 480
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001369826.1 → NP_001356755.1  zinc finger protein 841 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 3, 7, and 8, encodes isoform 1.
    Source sequence(s)
    AC011468
    Consensus CDS
    CCDS46161.1
    Related
    ENSP00000374185.4, ENST00000389534.8
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:483 → 885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_001369827.1 → NP_001356756.1  zinc finger protein 841 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 3, 6, and 8, encodes isoform 1.
    Source sequence(s)
    AC011468
    Consensus CDS
    CCDS46161.1
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:483 → 885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. NM_001369828.1 → NP_001356757.1  zinc finger protein 841 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1, 3, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AC011468
    Consensus CDS
    CCDS46161.1
    Related
    ENSP00000470746.1, ENST00000594295.5
    Conserved Domains (3) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:483 → 885
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. NM_001369829.2 → NP_001356758.1  zinc finger protein 841 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC011468
    Conserved Domains (4) summary
    smart00349
    Location:8 → 68
    KRAB; krueppel associated box
    COG5048
    Location:342 → 755
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:459 → 479
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:752 → 776
    zf-H2C2_2; Zinc-finger double domain

  10. NM_001369830.1 → NP_001356759.1  zinc finger protein 841 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC011468
    Consensus CDS
    CCDS82388.1
    UniProtKB/Swiss-Prot
    B9EG58, Q6ZN19, Q6ZN82, Q6ZP71, Q8N9U7
    Conserved Domains (2) summary
    COG5048
    Location:367 → 769
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:343 → 363
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    52058095..52095765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438655.1 → XP_047294611.1  zinc finger protein 841 isoform X2

  2. XM_047438652.1 → XP_047294608.1  zinc finger protein 841 isoform X1

  3. XM_047438653.1 → XP_047294609.1  zinc finger protein 841 isoform X2

  4. XM_017026653.2 → XP_016882142.1  zinc finger protein 841 isoform X1

    Conserved Domains (3) summary
    smart00349
    Location:8 → 69
    KRAB; krueppel associated box
    COG5048
    Location:484 → 886
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:460 → 480
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_047438651.1 → XP_047294607.1  zinc finger protein 841 isoform X1

  6. XM_047438654.1 → XP_047294610.1  zinc finger protein 841 isoform X2

  7. XM_047438650.1 → XP_047294606.1  zinc finger protein 841 isoform X1

  8. XM_047438649.1 → XP_047294605.1  zinc finger protein 841 isoform X1

  9. XM_047438656.1 → XP_047294612.1  zinc finger protein 841 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    55145315..55182977 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320656.1 → XP_054176631.1  zinc finger protein 841 isoform X2

  2. XM_054320653.1 → XP_054176628.1  zinc finger protein 841 isoform X1

  3. XM_054320654.1 → XP_054176629.1  zinc finger protein 841 isoform X2

  4. XM_054320649.1 → XP_054176624.1  zinc finger protein 841 isoform X1

  5. XM_054320652.1 → XP_054176627.1  zinc finger protein 841 isoform X1

  6. XM_054320655.1 → XP_054176630.1  zinc finger protein 841 isoform X2

  7. XM_054320651.1 → XP_054176626.1  zinc finger protein 841 isoform X1

  8. XM_054320650.1 → XP_054176625.1  zinc finger protein 841 isoform X1

  9. XM_054320657.1 → XP_054176632.1  zinc finger protein 841 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZN19.1 GenPept UniProtKB/Swiss-Prot:Q6ZN19

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