Format

Send to:

Choose Destination

PPP1R37 protein phosphatase 1 regulatory subunit 37 [ Homo sapiens (human) ]

Gene ID: 284352, updated on 7-Jun-2020

Summary

Official Symbol
PPP1R37provided by HGNC
Official Full Name
protein phosphatase 1 regulatory subunit 37provided by HGNC
Primary source
HGNC:HGNC:27607
See related
Ensembl:ENSG00000104866
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRRC68
Expression
Ubiquitous expression in kidney (RPKM 8.3), brain (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See PPP1R37 in Genome Data Viewer
Location:
19q13.32
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45093173..45147286)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45596431..45650543)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 296 Neighboring gene gem nuclear organelle associated protein 7 Neighboring gene GEMIN7 antisense RNA 1 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 3 Neighboring gene uncharacterized LOC105372420 Neighboring gene NTPase KAP family P-loop domain containing 1 Neighboring gene trafficking protein particle complex 6A Neighboring gene biogenesis of lysosomal organelles complex 1 subunit 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1986

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 37
Names
leucine rich repeat containing 68
leucine-rich repeat-containing protein 68

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019121.2NP_061994.1  protein phosphatase 1 regulatory subunit 37

    See identical proteins and their annotated locations for NP_061994.1

    Status: VALIDATED

    Source sequence(s)
    AC005757, AC011489
    Consensus CDS
    CCDS56096.1
    UniProtKB/Swiss-Prot
    O75864
    Related
    ENSP00000221462.3, ENST00000221462.9
    Conserved Domains (2) summary
    cd00116
    Location:110429
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:141163
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45093173..45147286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723159.3XP_006723222.1  protein phosphatase 1 regulatory subunit 37 isoform X1

    Conserved Domains (2) summary
    cd00116
    Location:110429
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:141163
    LRR_RI; leucine-rich repeat [structural motif]

RNA

  1. XR_001753668.1 RNA Sequence

Support Center