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TIMM8B translocase of inner mitochondrial membrane 8 homolog B [ Homo sapiens (human) ]

Gene ID: 26521, updated on 4-Jul-2021

Summary

Official Symbol
TIMM8Bprovided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 8 homolog Bprovided by HGNC
Primary source
HGNC:HGNC:11818
See related
Ensembl:ENSG00000150779 MIM:606659
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DDP2; TIM8B
Summary
This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]
Expression
Ubiquitous expression in heart (RPKM 16.7), colon (RPKM 15.7) and 25 other tissues See more
Orthologs
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Genomic context

See TIMM8B in Genome Data Viewer
Location:
11q23.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (112084800..112086756, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (111955524..111957480, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 893, pseudogene Neighboring gene dihydrolipoamide S-acetyltransferase Neighboring gene PIH1 domain containing 2 Neighboring gene NKAP domain containing 1 Neighboring gene succinate dehydrogenase complex subunit D Neighboring gene interleukin 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with translocase of inner mitochondrial membrane 8 homolog B (TIMM8B) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ21744, MGC102866, MGC117373

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim8 B
Names
DDP-like protein
deafness dystonia protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033145.1 RefSeqGene

    Range
    5043..6999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012459.4NP_036591.3  mitochondrial import inner membrane translocase subunit Tim8 B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AP002007
    Consensus CDS
    CCDS8357.2
    Related
    ENSP00000422122.2, ENST00000504148.3
    Conserved Domains (1) summary
    pfam02953
    Location:1674
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RNA

  1. NR_028383.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon, compared to variant 1. This variant (2) is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AP002007
    Related
    ENST00000509359.6
  2. NR_160400.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AP002007

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    112084800..112086756 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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