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Timm8b translocase of inner mitochondrial membrane 8B [ Mus musculus (house mouse) ]

Gene ID: 30057, updated on 5-Mar-2024

Summary

Official Symbol
Timm8bprovided by MGI
Official Full Name
translocase of inner mitochondrial membrane 8Bprovided by MGI
Primary source
MGI:MGI:1353424
See related
Ensembl:ENSMUSG00000039016 AllianceGenome:MGI:1353424
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tim8b
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within protein transport. Located in mitochondrion. Is expressed in several structures, including central nervous system; genitourinary system; nasal cavity epithelium; thymus primordium; and tooth. Orthologous to human TIMM8B (translocase of inner mitochondrial membrane 8 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 153.9), kidney adult (RPKM 127.9) and 28 other tissues See more
Orthologs
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Genomic context

Location:
9 A5.3; 9 27.75 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50515227..50516620)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50603901..50605320)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene interleukin 18 Neighboring gene testis expressed 12 Neighboring gene succinate dehydrogenase complex, subunit D, integral membrane protein Neighboring gene NKAP domain containing 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:50425377-50425486 Neighboring gene PIH1 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_24113 Neighboring gene dihydrolipoamide S-acetyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim8 B
Names
deafness dystonia protein 2 homolog
translocase of inner mitochondrial membrane 8 homolog b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013897.3NP_038925.1  mitochondrial import inner membrane translocase subunit Tim8 B

    See identical proteins and their annotated locations for NP_038925.1

    Status: VALIDATED

    Source sequence(s)
    AC025500
    Consensus CDS
    CCDS40624.1
    UniProtKB/Swiss-Prot
    P62077, Q3TF77, Q9QUT4
    Related
    ENSMUSP00000039335.5, ENSMUST00000044051.6
    Conserved Domains (1) summary
    pfam02953
    Location:1674
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    50515227..50516620
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)