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TIMM13 translocase of inner mitochondrial membrane 13 [ Homo sapiens (human) ]

Gene ID: 26517, updated on 1-Aug-2020

Summary

Official Symbol
TIMM13provided by HGNC
Official Full Name
translocase of inner mitochondrial membrane 13provided by HGNC
Primary source
HGNC:HGNC:11816
See related
Ensembl:ENSG00000099800 MIM:607383
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ppv1; TIM13; TIM13B; TIMM13A; TIMM13B
Summary
This gene encodes a member of the evolutionarily conserved TIMM (translocase of inner mitochondrial membrane) family of proteins that function as chaperones in the import of proteins from the cytoplasm into the mitochondrial inner membrane. Proteins of this family play a role in collecting substrate proteins from the translocase of the outer mitochondrial membrane (TOM) complex and delivering them to either the sorting and assembly machinery in the outer mitochondrial membrane (SAM) complex or the TIMM22 complex in the inner mitochondrial membrane. The encoded protein and the translocase of mitochondrial inner membrane 8a protein form a 70 kDa complex in the intermembrane space. [provided by RefSeq, Jul 2013]
Expression
Ubiquitous expression in kidney (RPKM 14.4), colon (RPKM 14.1) and 25 other tissues See more
Orthologs

Genomic context

See TIMM13 in Genome Data Viewer
Location:
19p13.3
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2425625..2427586, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2425622..2427914, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928572 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated Neighboring gene signal peptide peptidase like 2B Neighboring gene transmembrane serine protease 9 Neighboring gene origin of replication adjacent to lamin B2 Neighboring gene lamin B2 Neighboring gene microRNA 7108 Neighboring gene long intergenic non-protein coding RNA 1775

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env HIV-1 gp41 is identified to have a physical interaction with translocase of inner mitochondrial membrane 13 homolog (TIMM13) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
chaperone-mediated protein transport TAS
Traceable Author Statement
more info
PubMed 
protein import into mitochondrial inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein targeting to mitochondrion TAS
Traceable Author Statement
more info
PubMed 
sensory perception of sound TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
fibrillar center IDA
Inferred from Direct Assay
more info
 
mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial intermembrane space protein transporter complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial intermembrane space protein transporter complex TAS
Traceable Author Statement
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
mitochondrial import inner membrane translocase subunit Tim13
Names
mitochondrial import inner membrane translocase subunit Tim13B
translocase of inner mitochondrial membrane 13 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012458.4NP_036590.1  mitochondrial import inner membrane translocase subunit Tim13

    See identical proteins and their annotated locations for NP_036590.1

    Status: REVIEWED

    Source sequence(s)
    AC011522, AK024764, HY098076
    Consensus CDS
    CCDS12089.1
    UniProtKB/Swiss-Prot
    Q9Y5L4
    Related
    ENSP00000215570.2, ENST00000215570.8
    Conserved Domains (1) summary
    pfam02953
    Location:2484
    zf-Tim10_DDP; Tim10/DDP family zinc finger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2425625..2427586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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