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DECR2 2,4-dienoyl-CoA reductase 2 [ Homo sapiens (human) ]

Gene ID: 26063, updated on 3-Dec-2023

Summary

Official Symbol
DECR2provided by HGNC
Official Full Name
2,4-dienoyl-CoA reductase 2provided by HGNC
Primary source
HGNC:HGNC:2754
See related
Ensembl:ENSG00000242612 MIM:615839; AllianceGenome:HGNC:2754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDCR; SDR17C1
Summary
Enables 2,4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 18.7), liver (RPKM 15.2) and 25 other tissues See more
Orthologs
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Genomic context

See DECR2 in Genome Data Viewer
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (401885..412482)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (398130..408668)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (451885..462482)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100134368 Neighboring gene post-GPI attachment to proteins 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:440484-440661 Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:449109-449694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:450865-451450 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene RAB11 family interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:492123-492661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495322-495822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495823-496323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516240-516869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516870-517498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:532003-532508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:534533-535038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:535039-535544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:537093-537971 Neighboring gene uncharacterized LOC107987417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:542303-542924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:544383-544961 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:544962-545539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:576271-576832 Neighboring gene long intergenic non-protein coding RNA 235

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: NME4

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables trans-2-enoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables trans-2-enoyl-CoA reductase (NADPH) activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation using acyl-CoA oxidase TAS
Traceable Author Statement
more info
 
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in unsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
Names
2,4-dienoyl-CoA reductase 2, peroxisomal
peroxisomal 2,4-dienoyl-CoA reductase
short chain dehydrogenase/reductase family 17C member 1
NP_065715.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020664.4NP_065715.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

    See identical proteins and their annotated locations for NP_065715.1

    Status: VALIDATED

    Source sequence(s)
    BC010740, BC030226
    Consensus CDS
    CCDS10409.1
    UniProtKB/Swiss-Prot
    Q6ZRS7, Q96ET0, Q9NUI1
    UniProtKB/TrEMBL
    Q4VXZ8
    Related
    ENSP00000219481.5, ENST00000219481.10
    Conserved Domains (1) summary
    cd05369
    Location:26273
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    401885..412482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187610.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1031..11628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    398130..408668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)