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NME4 NME/NM23 nucleoside diphosphate kinase 4 [ Homo sapiens (human) ]

Gene ID: 4833, updated on 13-Jan-2019

Summary

Official Symbol
NME4provided by HGNC
Official Full Name
NME/NM23 nucleoside diphosphate kinase 4provided by HGNC
Primary source
HGNC:HGNC:7852
See related
Ensembl:ENSG00000103202 MIM:601818
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NDPK-D; NM23H4; nm23-H4
Summary
The nucleoside diphosphate (NDP) kinases (EC 2.7.4.6) are ubiquitous enzymes that catalyze transfer of gamma-phosphates, via a phosphohistidine intermediate, between nucleoside and dioxynucleoside tri- and diphosphates. The enzymes are products of the nm23 gene family, which includes NME4 (Milon et al., 1997 [PubMed 9099850]).[supplied by OMIM, May 2008]
Expression
Ubiquitous expression in prostate (RPKM 37.4), fat (RPKM 31.4) and 25 other tissues See more
Orthologs

Genomic context

See NME4 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (396755..400754)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (446752..450754)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100134368 Neighboring gene uncharacterized LOC105371036 Neighboring gene transmembrane protein 8A Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene 2,4-dienoyl-CoA reductase 2 Neighboring gene RAB11 family interacting protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: DECR2

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cardiolipin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleoside diphosphate kinase activity EXP
Inferred from Experiment
more info
PubMed 
nucleoside diphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
CTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
GTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
UTP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid transport IDA
Inferred from Direct Assay
more info
PubMed 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleoside diphosphate phosphorylation IEA
Inferred from Electronic Annotation
more info
 
nucleoside metabolic process TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
nucleoside diphosphate kinase, mitochondrial
Names
NDK
NDP kinase D
NDP kinase, mitochondrial
NDPKD
non-metastatic cells 4, protein expressed in
nucleoside diphosphate kinase D
NP_001273362.1
NP_001273364.1
NP_001273365.1
NP_001273367.1
NP_001273368.1
NP_001273369.1
NP_005000.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286433.1NP_001273362.1  nucleoside diphosphate kinase, mitochondrial isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    BC004880, BC017067, HY182358
    Consensus CDS
    CCDS73797.1
    UniProtKB/Swiss-Prot
    O00746
    UniProtKB/TrEMBL
    A0A087WVT9
    Related
    ENSP00000479681.1, ENST00000621774.4
    Conserved Domains (2) summary
    cd04413
    Location:38133
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    pfam00334
    Location:38138
    NDK; Nucleoside diphosphate kinase
  2. NM_001286435.1NP_001273364.1  nucleoside diphosphate kinase, mitochondrial isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of the last exon compared to isoform 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    BC004880, BC017067, BE266496
    UniProtKB/Swiss-Prot
    O00746
    Related
    ENSP00000405925.1, ENST00000433358.5
    Conserved Domains (2) summary
    cd04413
    Location:38145
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    pfam00334
    Location:38159
    NDK; Nucleoside diphosphate kinase
  3. NM_001286436.1NP_001273365.1  nucleoside diphosphate kinase, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_001273365.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' UTR and initiates translation at an alternate downstream start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, 6, and 7 all encode the same isoform (d).
    Source sequence(s)
    BC004880, BQ650649, CB143020
    Consensus CDS
    CCDS66886.1
    UniProtKB/Swiss-Prot
    O00746
    Related
    ENSP00000380834.1, ENST00000397722.5
    Conserved Domains (1) summary
    cd04413
    Location:197
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
  4. NM_001286438.1NP_001273367.1  nucleoside diphosphate kinase, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_001273367.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon and initiates translation at an alternate downstream start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, 6, and 7 all encode the same isoform (d).
    Source sequence(s)
    BC004880, BC017067, BP328820
    Consensus CDS
    CCDS66886.1
    UniProtKB/Swiss-Prot
    O00746
    Conserved Domains (1) summary
    cd04413
    Location:197
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
  5. NM_001286439.1NP_001273368.1  nucleoside diphosphate kinase, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_001273368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate exon in the 5' UTR and initiates translation at an alternate downstream start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, 6, and 7 all encode the same isoform (d).
    Source sequence(s)
    BC004880, BC017067, CF126980
    Consensus CDS
    CCDS66886.1
    UniProtKB/Swiss-Prot
    O00746
    Related
    ENSP00000479996.1, ENST00000620944.4
    Conserved Domains (1) summary
    cd04413
    Location:197
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
  6. NM_001286440.1NP_001273369.1  nucleoside diphosphate kinase, mitochondrial isoform d

    See identical proteins and their annotated locations for NP_001273369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon and initiates translation at an alternate downstream start codon compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a. Variants 4, 5, 6, and 7 all encode the same isoform (d).
    Source sequence(s)
    BC004880, BG472605, BQ932845
    Consensus CDS
    CCDS66886.1
    UniProtKB/Swiss-Prot
    O00746
    Related
    ENSP00000389048.1, ENST00000450036.1
    Conserved Domains (1) summary
    cd04413
    Location:197
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
  7. NM_005009.3NP_005000.1  nucleoside diphosphate kinase, mitochondrial isoform a precursor

    See identical proteins and their annotated locations for NP_005000.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    BC004880, BC017067
    Consensus CDS
    CCDS10408.1
    UniProtKB/Swiss-Prot
    O00746
    Related
    ENSP00000219479.2, ENST00000219479.6
    Conserved Domains (2) summary
    smart00562
    Location:38172
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04413
    Location:38167
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    396755..400754
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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