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Decr2 2-4-dienoyl-Coenzyme A reductase 2, peroxisomal [ Mus musculus (house mouse) ]

Gene ID: 26378, updated on 8-Dec-2022

Summary

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Official Symbol
Decr2provided by MGI
Official Full Name
2-4-dienoyl-Coenzyme A reductase 2, peroxisomalprovided by MGI
Primary source
MGI:MGI:1347059
See related
Ensembl:ENSMUSG00000036775 AllianceGenome:MGI:1347059
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable 2,4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in unsaturated fatty acid biosynthetic process. Predicted to act upstream of or within fatty acid metabolic process. Predicted to be located in peroxisomal membrane. Orthologous to human DECR2 (2,4-dienoyl-CoA reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 56.4), bladder adult (RPKM 32.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Decr2 in Genome Data Viewer
Location:
17 A3.3; 17 13.06 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26300182..26309296, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26081208..26090322, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700022N22 gene Neighboring gene RAB11 family interacting protein 3 (class II) Neighboring gene membrane-associated ring finger (C3HC4) 5 pseudogene Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse gene PDCR encodes a peroxisomal delta(2), delta(4)-dienoyl-CoA reductase. Geisbrecht BV, et al. J Biol Chem, 1999 Sep 3. PMID 10464321
  2. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. De Nys K, et al. Biochim Biophys Acta, 2001 Aug 29. PMID 11514237
  3. Searching QTL by gene expression: analysis of diabesity. Brown AC, et al. BMC Genet, 2005 Mar 10. PMID 15760467, Free PMC Article
  4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables 2,4-dienoyl-CoA reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables trans-2-enoyl-CoA reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in fatty acid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in unsaturated fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in unsaturated fatty acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in peroxisomal membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]; peroxisomal 2,4-dienoyl-CoA reductase
Names
2,4-dienoyl-CoA reductase 2
NP_036063.1
XP_030105676.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411308.1 → NP_001398237.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140047
    UniProtKB/TrEMBL
    A0A494B909

  2. NM_001411309.1 → NP_001398238.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC140047

  3. NM_001411310.1 → NP_001398239.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140047
    UniProtKB/Swiss-Prot
    Q9WV68
    UniProtKB/TrEMBL
    Q3UVJ7

  4. NM_001411311.1 → NP_001398240.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140047
    UniProtKB/Swiss-Prot
    Q9WV68
    UniProtKB/TrEMBL
    Q3UVJ7

  5. NM_001411312.1 → NP_001398241.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC140047

  6. NM_001411313.1 → NP_001398242.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC140047

  7. NM_001411314.1 → NP_001398243.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC140047
    UniProtKB/TrEMBL
    A0A494BB28

  8. NM_001411315.1 → NP_001398244.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC140047

  9. NM_001411316.1 → NP_001398245.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC140047

  10. NM_001411317.1 → NP_001398246.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC140047

  11. NM_001411318.1 → NP_001398247.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC140047

  12. NM_011933.3 → NP_036063.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing] isoform 1

    See identical proteins and their annotated locations for NP_036063.1

    Status: VALIDATED

    Source sequence(s)
    AC140047
    Consensus CDS
    CCDS28543.1
    UniProtKB/Swiss-Prot
    Q9WV68
    UniProtKB/TrEMBL
    Q3UVJ7
    Related
    ENSMUSP00000045621.7, ENSMUST00000040907.8
    Conserved Domains (2) summary
    cd05369
    Location:26 → 273
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR
    PRK07576
    Location:26 → 271
    PRK07576; short chain dehydrogenase; Provisional

RNA

  1. NR_177215.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC140047

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26300182..26309296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249816.1 → XP_030105676.1  peroxisomal 2,4-dienoyl-CoA reductase isoform X1

    Related
    ENSMUSP00000157417.2, ENSMUST00000237875.2
    Conserved Domains (1) summary
    cl21454
    Location:1 → 189
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV68.1 GenPept UniProtKB/Swiss-Prot:Q9WV68

Gene LinkOut

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