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ZNF451 zinc finger protein 451 [ Homo sapiens (human) ]

Gene ID: 26036, updated on 3-Nov-2024

Summary

Official Symbol
ZNF451provided by HGNC
Official Full Name
zinc finger protein 451provided by HGNC
Primary source
HGNC:HGNC:21091
See related
Ensembl:ENSG00000112200 MIM:615708; AllianceGenome:HGNC:21091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZATT; COASTER; dJ417I1.1
Summary
Enables SUMO ligase activity; transcription corepressor activity; and transcription regulator inhibitor activity. Involved in negative regulation of transcription initiation by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in PML body. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 5.2) and 24 other tissues See more
Orthologs
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Genomic context

See ZNF451 in Genome Data Viewer
Location:
6p12.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (57090188..57170305)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (56929190..57009330)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (56954986..57035103)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:56895065-56895565 Neighboring gene Sharpr-MPRA regulatory region 7771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56912079-56912956 Neighboring gene mitochondrial ribosomal protein L30 pseudogene 1 Neighboring gene KIAA1586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56954672-56955554 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:57037271-57038028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17304 Neighboring gene BAG cochaperone 2 Neighboring gene RAB23, member RAS oncogene family Neighboring gene DNA primase subunit 2 Neighboring gene long intergenic non-protein coding RNA 3001

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ23421, FLJ53246, FLJ90693, KIAA0576, KIAA1702, MGC26701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase ZNF451
Names
E3 SUMO-protein transferase ZNF451
coactivator for steroid receptors
zinc finger protein associated with TDP2 and TOP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031623.3NP_001026794.1  E3 SUMO-protein ligase ZNF451 isoform 1

    See identical proteins and their annotated locations for NP_001026794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB011148, AK027805, AL136311, AY055204, CN314846
    Consensus CDS
    CCDS43477.1
    UniProtKB/Swiss-Prot
    Q5VVE9, Q5VVF1, Q86YE4, Q8N380, Q8TD15, Q9C0G1, Q9NQM1, Q9Y4E5
    UniProtKB/TrEMBL
    E9PH99
    Related
    ENSP00000359740.4, ENST00000370706.9
  2. NM_001257273.2NP_001244202.1  E3 SUMO-protein ligase ZNF451 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK302577, AL450489, CK301064
    Consensus CDS
    CCDS59026.1
    UniProtKB/TrEMBL
    B4DYS2
    Related
    ENSP00000359742.4, ENST00000370708.8
    Conserved Domains (1) summary
    pfam11560
    Location:358498
    LAP2alpha; Lamina-associated polypeptide 2 alpha
  3. NM_015555.3NP_056370.2  E3 SUMO-protein ligase ZNF451 isoform 2

    See identical proteins and their annotated locations for NP_056370.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. Isoform 2 is shorter, compared to isoform 1.
    Source sequence(s)
    AA336048, AL136311, AY055204, BM559241, CN314846
    Consensus CDS
    CCDS4960.1
    UniProtKB/TrEMBL
    E9PH99
    Related
    ENSP00000350083.3, ENST00000357489.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    57090188..57170305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514460.3XP_011512762.1  E3 SUMO-protein ligase ZNF451 isoform X1

    UniProtKB/TrEMBL
    E9PH99
  2. XM_047418624.1XP_047274580.1  E3 SUMO-protein ligase ZNF451 isoform X3

  3. XM_011514462.4XP_011512764.1  E3 SUMO-protein ligase ZNF451 isoform X4

    UniProtKB/TrEMBL
    E9PH99
    Related
    ENST00000444273.6
  4. XM_011514463.3XP_011512765.1  E3 SUMO-protein ligase ZNF451 isoform X5

    Conserved Domains (1) summary
    pfam11560
    Location:330470
    LAP2alpha; Lamina-associated polypeptide 2 alpha
  5. XM_011514461.3XP_011512763.1  E3 SUMO-protein ligase ZNF451 isoform X2

    UniProtKB/TrEMBL
    E9PH99

RNA

  1. XR_007059234.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    56929190..57009330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355130.1XP_054211105.1  E3 SUMO-protein ligase ZNF451 isoform X1

  2. XM_054355132.1XP_054211107.1  E3 SUMO-protein ligase ZNF451 isoform X3

  3. XM_054355133.1XP_054211108.1  E3 SUMO-protein ligase ZNF451 isoform X4

  4. XM_054355134.1XP_054211109.1  E3 SUMO-protein ligase ZNF451 isoform X5

  5. XM_054355131.1XP_054211106.1  E3 SUMO-protein ligase ZNF451 isoform X2

RNA

  1. XR_008487294.1 RNA Sequence