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ZNF451 zinc finger protein 451 [ Homo sapiens (human) ]

Gene ID: 26036, updated on 7-Oct-2018

Summary

Official Symbol
ZNF451provided by HGNC
Official Full Name
zinc finger protein 451provided by HGNC
Primary source
HGNC:HGNC:21091
See related
Ensembl:ENSG00000112200 MIM:615708; Vega:OTTHUMG00000014916
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COASTER; dJ417I1.1
Expression
Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 5.2) and 24 other tissues See more
Orthologs

Genomic context

See ZNF451 in Genome Data Viewer
Location:
6p12.1
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 6 NC_000006.12 (57088970..57170305)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (56954808..57035103)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L30 pseudogene 1 Neighboring gene KIAA1586 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene BCL2 associated athanogene 2 Neighboring gene RAB23, member RAS oncogene family

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23421, FLJ53246, FLJ90693, KIAA0576, KIAA1702, MGC26701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific NAS
Non-traceable Author Statement
more info
PubMed 
SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
PML body IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with histone methyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase ZNF451
Names
E3 SUMO-protein transferase ZNF451
coactivator for steroid receptors

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031623.2NP_001026794.1  E3 SUMO-protein ligase ZNF451 isoform 1

    See identical proteins and their annotated locations for NP_001026794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB011148, AK027805, AY055204, CN314846
    Consensus CDS
    CCDS43477.1
    UniProtKB/Swiss-Prot
    Q9Y4E5
    UniProtKB/TrEMBL
    Q96JY2
    Related
    ENSP00000359740.4, OTTHUMP00000016663, ENST00000370706.8, OTTHUMT00000041035
  2. NM_001257273.1NP_001244202.1  E3 SUMO-protein ligase ZNF451 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK302577, AL450489, CK301064
    Consensus CDS
    CCDS59026.1
    UniProtKB/TrEMBL
    B4DYS2
    Related
    ENSP00000359742.4, OTTHUMP00000016664, ENST00000370708.8, OTTHUMT00000041036
    Conserved Domains (1) summary
    pfam11560
    Location:358498
    LAP2alpha; Lamina-associated polypeptide 2 alpha
  3. NM_015555.2NP_056370.2  E3 SUMO-protein ligase ZNF451 isoform 2

    See identical proteins and their annotated locations for NP_056370.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. Isoform 2 is shorter, compared to isoform 1.
    Source sequence(s)
    AA336048, AY055204, BM559241, CN314846
    Consensus CDS
    CCDS4960.1
    UniProtKB/Swiss-Prot
    Q9Y4E5
    Related
    ENSP00000350083.3, OTTHUMP00000218131, ENST00000357489.7, OTTHUMT00000360462

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p12 Primary Assembly

    Range
    57088970..57170305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005248994.2XP_005249051.1  E3 SUMO-protein ligase ZNF451 isoform X3

  2. XM_011514462.3XP_011512764.1  E3 SUMO-protein ligase ZNF451 isoform X4

  3. XM_011514460.2XP_011512762.1  E3 SUMO-protein ligase ZNF451 isoform X1

  4. XM_011514463.2XP_011512765.1  E3 SUMO-protein ligase ZNF451 isoform X5

    Conserved Domains (1) summary
    pfam11560
    Location:330470
    LAP2alpha; Lamina-associated polypeptide 2 alpha
  5. XM_011514461.2XP_011512763.1  E3 SUMO-protein ligase ZNF451 isoform X2

RNA

  1. XR_001743327.2 RNA Sequence

  2. XR_001743328.2 RNA Sequence

  3. XR_241885.2 RNA Sequence

  4. XR_001743329.1 RNA Sequence

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