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Zfp451 zinc finger protein 451 [ Mus musculus (house mouse) ]

Gene ID: 98403, updated on 9-May-2024

Summary

Official Symbol
Zfp451provided by MGI
Official Full Name
zinc finger protein 451provided by MGI
Primary source
MGI:MGI:2137896
See related
Ensembl:ENSMUSG00000042197 AllianceGenome:MGI:2137896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf451; COASTER; mKIAA1702; Kiaa0576-hp; 4930515K21Rik; 4933435G09Rik
Summary
Predicted to enable SUMO ligase activity and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of histone H3-K9 acetylation; protein sumoylation; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in brain; early conceptus; gonad; and metanephros. Orthologous to human ZNF451 (zinc finger protein 451). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 22.2), CNS E11.5 (RPKM 5.4) and 12 other tissues See more
Orthologs
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Genomic context

See Zfp451 in Genome Data Viewer
Location:
1 B; 1 12.81 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33800622..33854683, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33761541..33815602, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RAB23, member RAS oncogene family Neighboring gene BCL2-associated athanogene 2 Neighboring gene STARR-seq mESC enhancer starr_00543 Neighboring gene predicted gene 15455 Neighboring gene BEN domain containing 6 Neighboring gene predicted gene, 38471

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables SUMO ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 SUMO-protein ligase ZNF451
Names
E3 SUMO-protein transferase ZNF451

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290699.1NP_001277628.1  E3 SUMO-protein ligase ZNF451 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC163668, AI596398, AK015797, AK030088
    UniProtKB/TrEMBL
    Q6P6L8
    Conserved Domains (1) summary
    cd18721
    Location:722838
    PIN_ZNF451-like; LabA-like PIN domain of human zinc finger protein 451 and related proteins
  2. NM_001290700.1NP_001277629.1  E3 SUMO-protein ligase ZNF451 isoform 3

    See identical proteins and their annotated locations for NP_001277629.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a distinct 3' structure and 3' terminus, compared to variant 1. The encoded protein (isoform 3) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC163668, AK015797
    Consensus CDS
    CCDS69873.1
    UniProtKB/TrEMBL
    Q80TA4, Q8VCL4
    Related
    ENSMUSP00000044372.6, ENSMUST00000044455.8
    Conserved Domains (1) summary
    pfam11560
    Location:357492
    LAP2alpha; Lamina-associated polypeptide 2 alpha
  3. NM_001359274.1NP_001346203.1  E3 SUMO-protein ligase ZNF451 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC163668
    UniProtKB/TrEMBL
    Q6P6L8
  4. NM_001359275.1NP_001346204.1  E3 SUMO-protein ligase ZNF451 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC163668
    UniProtKB/TrEMBL
    Q6P6L8
  5. NM_133817.3NP_598578.1  E3 SUMO-protein ligase ZNF451 isoform 1

    See identical proteins and their annotated locations for NP_598578.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC163668, AI596398, AK015797, AK030088
    Consensus CDS
    CCDS14865.1
    UniProtKB/Swiss-Prot
    Q8C0P7
    UniProtKB/TrEMBL
    Q6P6L8
    Related
    ENSMUSP00000019861.7, ENSMUST00000019861.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    33800622..33854683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154651.1XP_036010544.1  E3 SUMO-protein ligase ZNF451 isoform X1

    UniProtKB/TrEMBL
    Q6P6L8
    Conserved Domains (1) summary
    pfam18479
    Location:741858
    PIN_11; PIN like domain
  2. XM_036154666.1XP_036010559.1  E3 SUMO-protein ligase ZNF451 isoform X2

    UniProtKB/TrEMBL
    Q6P6L8
    Conserved Domains (1) summary
    pfam18479
    Location:553670
    PIN_11; PIN like domain
  3. XM_030243891.2XP_030099751.1  E3 SUMO-protein ligase ZNF451 isoform X1

    UniProtKB/TrEMBL
    Q6P6L8
    Conserved Domains (1) summary
    pfam18479
    Location:741858
    PIN_11; PIN like domain

RNA

  1. XR_865290.4 RNA Sequence

  2. XR_865291.4 RNA Sequence