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DHRS7B dehydrogenase/reductase 7B [ Homo sapiens (human) ]

Gene ID: 25979, updated on 9-Sep-2025
Official Symbol
DHRS7Bprovided by HGNC
Official Full Name
dehydrogenase/reductase 7Bprovided by HGNC
Primary source
HGNC:HGNC:24547
See related
Ensembl:ENSG00000109016 MIM:616160; AllianceGenome:HGNC:24547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-93; SDR32C1
Summary
Predicted to enable acylglycerone-phosphate reductase (NADP+) activity. Predicted to be involved in ether lipid biosynthetic process. Predicted to act upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane. [provided by Alliance of Genome Resources, Apr 2025]
Expression
Ubiquitous expression in testis (RPKM 7.1), thyroid (RPKM 6.1) and 25 other tissues See more
Orthologs
mouse all
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See DHRS7B in Genome Data Viewer
Location:
17p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (21126964..21191420)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (21068745..21140297)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (21030277..21094733)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900389 Neighboring gene ubiquitin specific peptidase 22 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:20937215-20937716 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20946145-20947094 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20947095-20948042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:20954728-20955314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11877 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20970211-20970711 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:20978550-20979050 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:20987896-20989095 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr17:21002173-21002789 and GRCh37_chr17:21002790-21003407 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:21011664-21012527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11879 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:21102215-21103012 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:21108419-21109051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11880 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8313 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8314 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11881 Neighboring gene transmembrane protein 11 Neighboring gene TMEM11 divergent transcript

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Genome-wide association study identifies loci affecting blood copper, selenium and zinc. Evans DM, et al. Hum Mol Genet, 2013 Oct 1. PMID 23720494, Free PMC Article
  2. WWP2-WWP1 ubiquitin ligase complex coordinated by PPM1G maintains the balance between cellular p73 and ΔNp73 levels. Chaudhary N, et al. Mol Cell Biol, 2014 Oct 1. PMID 25071155, Free PMC Article
  3. VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma. Zhang Q, et al. Cell Oncol (Dordr), 2023 Aug. PMID 36929488
  4. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. Lai CH, et al. Genome Res, 2000 May. PMID 10810093, Free PMC Article
  5. High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines. Wang S, et al. Int J Mol Sci, 2018 Dec 19. PMID 30572598, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
EBI GWAS Catalog

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC8916, FLJ42061, FLJ99908, DKFZp566O084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables acylglycerone-phosphate reductase (NADP+) activity TAS
Traceable Author Statement
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ether lipid biosynthetic process TAS
Traceable Author Statement
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
  
Preferred Names
dehydrogenase/reductase SDR family member 7B
Names
dehydrogenase/reductase (SDR family) member 7B
short-chain dehydrogenase/reductase family 32C member 1
NP_001317088.1
NP_001380586.1
NP_001380587.1
NP_001380588.1
NP_001380589.1
NP_056325.2
XP_011522088.1
XP_024306453.1
XP_047291678.1
XP_047291679.1
XP_047291680.1
XP_047291681.1
XP_054171637.1
XP_054171638.1
XP_054171639.1
XP_054171640.1
XP_054171641.1
XP_054171642.1
XP_054171643.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330159.3 → NP_001317088.1  dehydrogenase/reductase SDR family member 7B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Consensus CDS
    CCDS82092.1
    UniProtKB/TrEMBL
    A0A0C4DGQ8
    Related
    ENSP00000468585.1, ENST00000579303.5

  2. NM_001393657.1 → NP_001380586.1  dehydrogenase/reductase SDR family member 7B isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Conserved Domains (1) summary
    cd05332
    Location:50 → 309
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  3. NM_001393658.1 → NP_001380587.1  dehydrogenase/reductase SDR family member 7B isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Conserved Domains (1) summary
    cd05332
    Location:50 → 307
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  4. NM_001393659.1 → NP_001380588.1  dehydrogenase/reductase SDR family member 7B isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Conserved Domains (1) summary
    cl21454
    Location:50 → 260
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. NM_001393660.1 → NP_001380589.1  dehydrogenase/reductase SDR family member 7B isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Related
    ENSP00000551461.1, ENST00000881402.1
    Conserved Domains (1) summary
    cd05332
    Location:50 → 260
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  6. NM_015510.5 → NP_056325.2  dehydrogenase/reductase SDR family member 7B isoform 1

    See identical proteins and their annotated locations for NP_056325.2

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Consensus CDS
    CCDS11215.1
    UniProtKB/Swiss-Prot
    B5MEF4, Q6IAN0, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1
    Related
    ENSP00000378887.3, ENST00000395511.8
    Conserved Domains (1) summary
    cd05332
    Location:50 → 311
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    21126964..21191420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435722.1 → XP_047291678.1  dehydrogenase/reductase SDR family member 7B isoform X1

  2. XM_011523786.3 → XP_011522088.1  dehydrogenase/reductase SDR family member 7B isoform X4

    Conserved Domains (2) summary
    cd05332
    Location:97 → 304
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:101 → 294
    adh_short; short chain dehydrogenase

  3. XM_024450685.2 → XP_024306453.1  dehydrogenase/reductase SDR family member 7B isoform X6

    Conserved Domains (1) summary
    cd05332
    Location:50 → 257
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

  4. XM_047435724.1 → XP_047291680.1  dehydrogenase/reductase SDR family member 7B isoform X3

  5. XM_047435723.1 → XP_047291679.1  dehydrogenase/reductase SDR family member 7B isoform X2

  6. XM_047435725.1 → XP_047291681.1  dehydrogenase/reductase SDR family member 7B isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    21068745..21140297
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315667.1 → XP_054171642.1  dehydrogenase/reductase SDR family member 7B isoform X7

    UniProtKB/Swiss-Prot
    B5MEF4, Q6IAN0, Q6UX59, Q9BTF9, Q9UFM6, Q9Y3A1

  2. XM_054315662.1 → XP_054171637.1  dehydrogenase/reductase SDR family member 7B isoform X1

  3. XM_054315665.1 → XP_054171640.1  dehydrogenase/reductase SDR family member 7B isoform X4

  4. XM_054315668.1 → XP_054171643.1  dehydrogenase/reductase SDR family member 7B isoform X6

  5. XM_054315664.1 → XP_054171639.1  dehydrogenase/reductase SDR family member 7B isoform X3

  6. XM_054315663.1 → XP_054171638.1  dehydrogenase/reductase SDR family member 7B isoform X2

  7. XM_054315666.1 → XP_054171641.1  dehydrogenase/reductase SDR family member 7B isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001393656.1: Suppressed sequence

    Description
    NM_001393656.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IAN0.2 GenPept UniProtKB/Swiss-Prot:Q6IAN0

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