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DHRS7B dehydrogenase/reductase 7B [ Homo sapiens (human) ]

Gene ID: 25979, updated on 1-Jun-2020

Summary

Official Symbol
DHRS7Bprovided by HGNC
Official Full Name
dehydrogenase/reductase 7Bprovided by HGNC
Primary source
HGNC:HGNC:24547
See related
Ensembl:ENSG00000109016 MIM:616160
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-93; SDR32C1
Summary
This gene is located within the Smith-Magenis syndrome region on chromosome 17. It encodes a protein of unknown function. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 7.1), thyroid (RPKM 6.1) and 25 other tissues See more
Orthologs

Genomic context

See DHRS7B in Genome Data Viewer
Location:
17p11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (21123368..21192030)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (21030241..21095285)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 22 Neighboring gene long intergenic non-protein coding RNA 1563 Neighboring gene uncharacterized LOC107984969 Neighboring gene transmembrane protein 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC8916, FLJ42061, FLJ99908, DKFZp566O084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
ether lipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil differentiation IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 7B
Names
dehydrogenase/reductase (SDR family) member 7B
short-chain dehydrogenase/reductase family 32C member 1
NP_001317088.1
NP_056325.2
XP_005256652.2
XP_011522088.1
XP_016879915.1
XP_024306453.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330159.2NP_001317088.1  dehydrogenase/reductase SDR family member 7B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC087393
    Consensus CDS
    CCDS82092.1
    UniProtKB/Swiss-Prot
    Q6IAN0
    UniProtKB/TrEMBL
    A0A0C4DGQ8
    Related
    ENSP00000468585.1, ENST00000579303.5
  2. NM_015510.4NP_056325.2  dehydrogenase/reductase SDR family member 7B isoform 1

    See identical proteins and their annotated locations for NP_056325.2

    Status: VALIDATED

    Source sequence(s)
    AI018764, BC009679, BI460496, BQ181209, DA653503
    Consensus CDS
    CCDS11215.1
    UniProtKB/Swiss-Prot
    Q6IAN0
    Related
    ENSP00000378887.3, ENST00000395511.7
    Conserved Domains (1) summary
    cd05332
    Location:50311
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    21123368..21192030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024426.2XP_016879915.1  dehydrogenase/reductase SDR family member 7B isoform X3

    UniProtKB/Swiss-Prot
    Q6IAN0
    Conserved Domains (1) summary
    cd05332
    Location:50311
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
  2. XM_011523786.2XP_011522088.1  dehydrogenase/reductase SDR family member 7B isoform X2

    Conserved Domains (2) summary
    cd05332
    Location:97304
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    pfam00106
    Location:101294
    adh_short; short chain dehydrogenase
  3. XM_024450685.1XP_024306453.1  dehydrogenase/reductase SDR family member 7B isoform X4

    Conserved Domains (1) summary
    cd05332
    Location:50257
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
  4. XM_005256595.4XP_005256652.2  dehydrogenase/reductase SDR family member 7B isoform X1

    Conserved Domains (2) summary
    cd05332
    Location:97358
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    PRK06181
    Location:99368
    PRK06181; short chain dehydrogenase; Provisional
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