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Dhrs7b dehydrogenase/reductase 7B [ Mus musculus (house mouse) ]

Gene ID: 216820, updated on 2-Nov-2024

Summary

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Official Symbol
Dhrs7bprovided by MGI
Official Full Name
dehydrogenase/reductase 7Bprovided by MGI
Primary source
MGI:MGI:2384931
See related
Ensembl:ENSMUSG00000042569 AllianceGenome:MGI:2384931
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PexRAP
Summary
Enables DNA-binding transcription factor binding activity and transcription corepressor activity. Involved in ether lipid biosynthetic process and neutrophil differentiation. Acts upstream of or within several processes, including brown fat cell differentiation; phosphatidylcholine biosynthetic process; and regulation of cold-induced thermogenesis. Located in membrane; nucleus; and peroxisome. Part of transcription regulator complex. Orthologous to human DHRS7B (dehydrogenase/reductase 7B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in large intestine adult (RPKM 20.2), mammary gland adult (RPKM 15.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dhrs7b in Genome Data Viewer
Location:
11 B2; 11 37.87 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60721457..60749249)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60830631..60858423)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene serine hydroxymethyltransferase 1 (soluble) Neighboring gene STARR-positive B cell enhancer ABC_E6992 Neighboring gene phosphoserine aminotransferase 1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E8411 Neighboring gene transmembrane protein 11 Neighboring gene STARR-positive B cell enhancer ABC_E10679 Neighboring gene STARR-seq mESC enhancer starr_29661 Neighboring gene predicted gene, 26534

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity. Lodhi IJ, et al. Cell Metab, 2012 Aug 8. PMID 22863804, Free PMC Article
  2. Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability. Lodhi IJ, et al. Cell Metab, 2015 Jan 6. PMID 25565205, Free PMC Article
  3. PexRAP Inhibits PRDM16-Mediated Thermogenic Gene Expression. Lodhi IJ, et al. Cell Rep, 2017 Sep 19. PMID 28930673, Free PMC Article
  4. Progesterone receptor membrane component 1 is a functional part of the glucagon-like peptide-1 (GLP-1) receptor complex in pancreatic β cells. Zhang M, et al. Mol Cell Proteomics, 2014 Nov. PMID 25044020, Free PMC Article
  5. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Theisen DJ, et al. Science, 2018 Nov 9. PMID 30409884, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6908

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables acylglycerone-phosphate reductase (NADP+) activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within adipose tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brown fat cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ether lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutrophil differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phosphatidylcholine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 7B
Names
dehydrogenase/reductase (SDR family) member 7B
short-chain dehydrogenase/reductase family 32C member 1
NP_001165583.1
NP_663403.1
XP_006532932.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172112.1 → NP_001165583.1  dehydrogenase/reductase SDR family member 7B isoform 1

    See identical proteins and their annotated locations for NP_001165583.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript but encodes the shorter isoform (1).
    Source sequence(s)
    AK139084, AL596215
    UniProtKB/TrEMBL
    Z4YKT6
    Related
    ENSMUSP00000104358.2, ENSMUST00000108718.2
    Conserved Domains (2) summary
    cd05332
    Location:41 → 300
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    PRK06181
    Location:45 → 310
    PRK06181; short chain dehydrogenase; Provisional

  2. NM_145428.2 → NP_663403.1  dehydrogenase/reductase SDR family member 7B isoform 2

    See identical proteins and their annotated locations for NP_663403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AK052209, AK139084, AL596215
    Consensus CDS
    CCDS24800.1
    UniProtKB/Swiss-Prot
    Q3UNS3, Q5NCT5, Q99J47
    UniProtKB/TrEMBL
    I7DM66, Z4YKT6
    Related
    ENSMUSP00000044924.8, ENSMUST00000042281.14
    Conserved Domains (2) summary
    cd05332
    Location:50 → 309
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
    PRK06181
    Location:52 → 319
    PRK06181; short chain dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    60721457..60749249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532869.5 → XP_006532932.1  dehydrogenase/reductase SDR family member 7B isoform X1

    UniProtKB/TrEMBL
    Z4YKT6
    Conserved Domains (1) summary
    cd05332
    Location:48 → 307
    11beta-HSD1_like_SDR_c; 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99J47.1 GenPept UniProtKB/Swiss-Prot:Q99J47

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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