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ABI3BP ABI family member 3 binding protein [ Homo sapiens (human) ]

Gene ID: 25890, updated on 23-Nov-2023

Summary

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Official Symbol
ABI3BPprovided by HGNC
Official Full Name
ABI family member 3 binding proteinprovided by HGNC
Primary source
HGNC:HGNC:17265
See related
Ensembl:ENSG00000154175 MIM:606279; AllianceGenome:HGNC:17265
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TARSH; NESHBP
Summary
Predicted to enable actin filament binding activity and glycosaminoglycan binding activity. Predicted to be involved in regulation of actin cytoskeleton reorganization; regulation of dendritic spine morphogenesis; and regulation of postsynaptic density assembly. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in gall bladder (RPKM 33.8), lung (RPKM 26.2) and 21 other tissues See more
Orthologs
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Genomic context

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See ABI3BP in Genome Data Viewer
Location:
3q12.2
Exon count:
68
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100749156..100993421, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103454905..103699234, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100468000..100712265, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20163 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100427906-100428797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100428798-100429688 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100456051-100456928 Neighboring gene trafficking from ER to golgi regulator Neighboring gene uncharacterized LOC124906260 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63759 Neighboring gene Sharpr-MPRA regulatory region 7106 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63902 Neighboring gene Sharpr-MPRA regulatory region 14979 Neighboring gene ABRAXAS1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 865, pseudogene Neighboring gene Sharpr-MPRA regulatory region 13899 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:100847709-100847923 Neighboring gene OCT4 hESC enhancer GRCh37_chr3:100917183-100917684 Neighboring gene small nucleolar RNA U13 Neighboring gene ACTR3 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease. Zhang F, et al. Hum Genet, 2014 Jun. PMID 24442417
  2. Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion. Latini FR, et al. Endocr Relat Cancer, 2008 Sep. PMID 18559958, Free PMC Article
  3. Cancer-associated loss of TARSH gene expression in human primary lung cancer. Terauchi K, et al. J Cancer Res Clin Oncol, 2006 Jan. PMID 16205947
  4. The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma. Cai H, et al. Mediators Inflamm, 2020. PMID 32774142, Free PMC Article
  5. Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells. Lin N, et al. J Exp Clin Cancer Res, 2019 Jun 7. PMID 31174563, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A Potential Four-Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer.
    Title: A Potential Four-Gene Signature and Nomogram for Predicting the Overall Survival of Papillary Thyroid Cancer.
  2. The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma.
    Title: The Depletion of ABI3BP by MicroRNA-183 Promotes the Development of Esophageal Carcinoma.
  3. The current study clarifies that MALAT1 silencing and ABI3BP elevation impede the GBC development through the H3K27 methylation suppression induced by EZH2, highlighting a promising competitive paradigm for therapeutic approaches of GBC.
    Title: Long noncoding RNA MALAT1 potentiates growth and inhibits senescence by antagonizing ABI3BP in gallbladder cancer cells.
  4. ABI3BP is a susceptibility gene for Kashin-Beck disease in the Chinese Han population.
    Title: Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin-Beck disease.
  5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
    Title: Genome-wide association study of suicide attempts in mood disorder patients.
  6. These results suggest that TARSH plays an important role in proliferation of replicative senescence and may serve as a trigger of tumor development.
    Title: Implication of p53-dependent cellular senescence related gene, TARSH in tumor suppression.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
  8. The loss of ABI3BP expression could play a functional role in thyroid tumorigenesis.
    Title: Re-expression of ABI3-binding protein suppresses thyroid tumor growth by promoting senescence and inhibiting invasion.
  9. Thus, TARSH presumably represents a trigger gene for evoking cellular senescence, which has also been suggested to be involved in the prevention of tumorigenesis.
    Title: Expression of TARSH gene in MEFs senescence and its potential implication in human lung cancer.
  10. expression of TARSH mRNA is remarkably downregulated in all lung cancer cell lines examined; also TARSH expression was significantly low in all of the tumor specimens when compared to the expression in corresponding non-neoplastic lung tissue specimens
    Title: Cancer-associated loss of TARSH gene expression in human primary lung cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.
EBI GWAS Catalog
Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41743, FLJ41754

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell-substrate adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
colocalizes_with collagen-containing extracellular matrix HDA PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region HDA PubMed 
located_in extracellular space HDA PubMed 

General protein information

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Preferred Names
target of Nesh-SH3
Names
ABI family, member 3 (NESH) binding protein
ABI gene family member 3-binding protein
ABI gene family, member 3 (NESH) binding protein
nesh-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001349329.2 → NP_001336258.2  target of Nesh-SH3 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    Conserved Domains (4) summary
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:700 → 1197
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:1080 → 1332
    PRK10263; DNA translocase FtsK; Provisional
    cd00063
    Location:1479 → 1570
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. NM_001349330.2 → NP_001336259.2  target of Nesh-SH3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    Conserved Domains (4) summary
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:670 → 1127
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:1010 → 1262
    PRK10263; DNA translocase FtsK; Provisional
    cd00063
    Location:1409 → 1500
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  3. NM_001349331.2 → NP_001336260.2  target of Nesh-SH3 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    Consensus CDS
    CCDS93332.1
    UniProtKB/TrEMBL
    A0A1S5UZ16, H7C556
    Related
    ENSP00000419029.3, ENST00000486770.7
    Conserved Domains (4) summary
    PHA03247
    Location:422 → 845
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:986 → 1077
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:116 → 195
    fn3; Fibronectin type III domain
    pfam17823
    Location:289 → 546
    DUF5585; Family of unknown function (DUF5585)

  4. NM_001349332.2 → NP_001336261.2  target of Nesh-SH3 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    UniProtKB/TrEMBL
    A0A1S5UZ16
    Conserved Domains (4) summary
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:257 → 591
    PHA03247; large tegument protein UL36; Provisional
    PHA03307
    Location:422 → 832
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00063
    Location:857 → 948
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  5. NM_001365642.2 → NP_001352571.2  target of Nesh-SH3 isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    UniProtKB/TrEMBL
    A0A1S5UZ16
    Conserved Domains (3) summary
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:447 → 867
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:1108 → 1199
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  6. NM_001365643.2 → NP_001352572.2  target of Nesh-SH3 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC080014, AC093009, AC106721
    Consensus CDS
    CCDS93333.1
    UniProtKB/TrEMBL
    F6R962, Q5JPC9
    Related
    ENSP00000433993.2, ENST00000495063.6
    Conserved Domains (2) summary
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:471 → 926
    PHA03247; large tegument protein UL36; Provisional

  7. NM_001375547.2 → NP_001362476.1  target of Nesh-SH3 isoform 8 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    Consensus CDS
    CCDS93334.1
    UniProtKB/TrEMBL
    D3YTG3
    Related
    ENSP00000420524.2, ENST00000471714.6
    Conserved Domains (4) summary
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:771 → 1268
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:1151 → 1403
    PRK10263; DNA translocase FtsK; Provisional
    cd00063
    Location:1550 → 1641
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  8. NM_001375549.2 → NP_001362478.1  target of Nesh-SH3 isoform 9 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    Conserved Domains (4) summary
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:771 → 1268
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:1151 → 1387
    PRK10263; DNA translocase FtsK; Provisional
    cd00063
    Location:1534 → 1625
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  9. NM_001375550.1 → NP_001362479.1  target of Nesh-SH3 isoform 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    Conserved Domains (4) summary
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:757 → 1254
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:1137 → 1389
    PRK10263; DNA translocase FtsK; Provisional
    cd00063
    Location:1536 → 1627
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  10. NM_001377332.1 → NP_001364261.1  target of Nesh-SH3 isoform 11 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    Conserved Domains (4) summary
    PTZ00449
    Location:900 → 1258
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    PHA03247
    Location:533 → 1073
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:1301 → 1392
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:116 → 195
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  11. NM_015429.4 → NP_056244.3  target of Nesh-SH3 isoform 5 precursor

    Status: VALIDATED

    Source sequence(s)
    AC068763, AC069223, AC080014, AC093009, AC106721
    Consensus CDS
    CCDS46880.2
    UniProtKB/Swiss-Prot
    B3KSL4, Q6ZW20, Q6ZW22, Q7Z7G0, Q9C082, Q9UFI6
    UniProtKB/TrEMBL
    A0A1S5UZ16
    Related
    ENSP00000284322.6, ENST00000284322.10
    Conserved Domains (4) summary
    PTZ00449
    Location:477 → 789
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    smart00060
    Location:117 → 195
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:257 → 591
    PHA03247; large tegument protein UL36; Provisional
    cd00063
    Location:832 → 923
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    100749156..100993421 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006713572.4 → XP_006713635.1  target of Nesh-SH3 isoform X39

    Conserved Domains (2) summary
    cd00063
    Location:1483 → 1574
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  2. XM_047447926.1 → XP_047303882.1  target of Nesh-SH3 isoform X45

  3. XM_047447922.1 → XP_047303878.1  target of Nesh-SH3 isoform X41

  4. XM_024453445.2 → XP_024309213.1  target of Nesh-SH3 isoform X46

    Conserved Domains (4) summary
    cd00063
    Location:1463 → 1554
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:123 → 202
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl26464
    Location:724 → 1181
    Atrophin-1; Atrophin-1 family
    cl28087
    Location:1064 → 1316
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  5. XM_047447921.1 → XP_047303877.1  target of Nesh-SH3 isoform X38

  6. XM_047447920.1 → XP_047303876.1  target of Nesh-SH3 isoform X36

  7. XM_005247299.5 → XP_005247356.1  target of Nesh-SH3 isoform X29

    Conserved Domains (2) summary
    cd00063
    Location:1508 → 1599
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  8. XM_011512641.3 → XP_011510943.1  target of Nesh-SH3 isoform X10

    Conserved Domains (4) summary
    smart00060
    Location:124 → 202
    FN3; Fibronectin type 3 domain
    PHA03247
    Location:753 → 1250
    PHA03247; large tegument protein UL36; Provisional
    PRK10263
    Location:1133 → 1385
    PRK10263; DNA translocase FtsK; Provisional
    cd00063
    Location:1532 → 1623
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  9. XM_011512648.3 → XP_011510950.1  target of Nesh-SH3 isoform X25

    Conserved Domains (2) summary
    cd00063
    Location:1511 → 1602
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  10. XM_047447919.1 → XP_047303875.1  target of Nesh-SH3 isoform X33

  11. XM_047447914.1 → XP_047303870.1  target of Nesh-SH3 isoform X20

  12. XM_047447917.1 → XP_047303873.1  target of Nesh-SH3 isoform X30

  13. XM_047447925.1 → XP_047303881.1  target of Nesh-SH3 isoform X44

  14. XM_047447918.1 → XP_047303874.1  target of Nesh-SH3 isoform X32

  15. XM_047447915.1 → XP_047303871.1  target of Nesh-SH3 isoform X21

  16. XM_005247288.4 → XP_005247345.1  target of Nesh-SH3 isoform X7

    Conserved Domains (2) summary
    cd00063
    Location:1533 → 1624
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  17. XM_006713571.4 → XP_006713634.1  target of Nesh-SH3 isoform X37

    Conserved Domains (2) summary
    cd00063
    Location:1485 → 1576
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  18. XM_011512640.3 → XP_011510942.1  target of Nesh-SH3 isoform X6

    Conserved Domains (2) summary
    cd00063
    Location:1535 → 1626
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  19. XM_011512643.3 → XP_011510945.1  target of Nesh-SH3 isoform X13

    Conserved Domains (2) summary
    cd00063
    Location:1530 → 1621
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  20. XM_011512647.3 → XP_011510949.1  target of Nesh-SH3 isoform X23

    Conserved Domains (2) summary
    cd00063
    Location:1512 → 1603
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  21. XM_047447923.1 → XP_047303879.1  target of Nesh-SH3 isoform X42

  22. XM_047447911.1 → XP_047303867.1  target of Nesh-SH3 isoform X17

  23. XM_011512646.3 → XP_011510948.1  target of Nesh-SH3 isoform X16

    Conserved Domains (2) summary
    cd00063
    Location:1526 → 1617
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  24. XM_005247295.4 → XP_005247352.1  target of Nesh-SH3 isoform X24

    Conserved Domains (2) summary
    cd00063
    Location:1511 → 1602
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  25. XM_024453444.2 → XP_024309212.1  target of Nesh-SH3 isoform X22

    Conserved Domains (4) summary
    smart00060
    Location:124 → 202
    FN3; Fibronectin type 3 domain
    cd00063
    Location:1512 → 1603
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl26464
    Location:803 → 1230
    Atrophin-1; Atrophin-1 family
    cl28087
    Location:1113 → 1365
    FtsK; DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell cycle control, cell division, chromosome partitioning]

  26. XM_005247289.4 → XP_005247346.1  target of Nesh-SH3 isoform X8

    Conserved Domains (2) summary
    cd00063
    Location:1532 → 1623
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  27. XM_047447924.1 → XP_047303880.1  target of Nesh-SH3 isoform X43

  28. XM_005247303.4 → XP_005247360.1  target of Nesh-SH3 isoform X40

    Conserved Domains (2) summary
    cd00063
    Location:1470 → 1561
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  29. XM_011512651.3 → XP_011510953.1  target of Nesh-SH3 isoform X35

    Conserved Domains (2) summary
    cd00063
    Location:1490 → 1581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  30. XM_005247296.4 → XP_005247353.1  target of Nesh-SH3 isoform X26

    Conserved Domains (2) summary
    cd00063
    Location:1510 → 1601
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  31. XM_047447912.1 → XP_047303868.1  target of Nesh-SH3 isoform X18

  32. XM_005247284.4 → XP_005247341.1  target of Nesh-SH3 isoform X1

    Conserved Domains (2) summary
    cd00063
    Location:1538 → 1629
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  33. XM_011512649.3 → XP_011510951.1  target of Nesh-SH3 isoform X27

    Conserved Domains (2) summary
    cd00063
    Location:1509 → 1600
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  34. XM_011512644.3 → XP_011510946.1  target of Nesh-SH3 isoform X14

    Conserved Domains (2) summary
    cd00063
    Location:1529 → 1620
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  35. XM_011512639.3 → XP_011510941.1  target of Nesh-SH3 isoform X4

    Conserved Domains (2) summary
    cd00063
    Location:1537 → 1628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  36. XM_005247285.4 → XP_005247342.1  target of Nesh-SH3 isoform X3

    Conserved Domains (2) summary
    cd00063
    Location:1537 → 1628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  37. XM_005247298.4 → XP_005247355.1  target of Nesh-SH3 isoform X28

    Conserved Domains (2) summary
    cd00063
    Location:1509 → 1600
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  38. XM_011512645.3 → XP_011510947.1  target of Nesh-SH3 isoform X15

    Conserved Domains (2) summary
    cd00063
    Location:1529 → 1620
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  39. XM_017006105.3 → XP_016861594.1  target of Nesh-SH3 isoform X2

  40. XM_017006106.3 → XP_016861595.1  target of Nesh-SH3 isoform X11

  41. XM_005247287.4 → XP_005247344.1  target of Nesh-SH3 isoform X5

    Conserved Domains (2) summary
    cd00063
    Location:1535 → 1626
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  42. XM_005247293.4 → XP_005247350.1  target of Nesh-SH3 isoform X19

    Conserved Domains (2) summary
    cd00063
    Location:1521 → 1612
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  43. XM_005247301.4 → XP_005247358.1  target of Nesh-SH3 isoform X34

    Conserved Domains (2) summary
    cd00063
    Location:1490 → 1581
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  44. XM_006713569.4 → XP_006713632.1  target of Nesh-SH3 isoform X31

    Conserved Domains (2) summary
    cd00063
    Location:1506 → 1597
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  45. XM_005247291.4 → XP_005247348.1  target of Nesh-SH3 isoform X12

    Conserved Domains (2) summary
    cd00063
    Location:1531 → 1622
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

  46. XM_005247290.4 → XP_005247347.1  target of Nesh-SH3 isoform X9

    Conserved Domains (2) summary
    cd00063
    Location:1532 → 1623
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:123 → 211
    fn3; Fibronectin type III domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    103454905..103699234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346084.1 → XP_054202059.1  target of Nesh-SH3 isoform X68

    UniProtKB/TrEMBL
    A0A1S5UZ16

  2. XM_054346083.1 → XP_054202058.1  target of Nesh-SH3 isoform X67

    UniProtKB/TrEMBL
    A0A1S5UZ16

  3. XM_054346080.1 → XP_054202055.1  target of Nesh-SH3 isoform X64

    UniProtKB/TrEMBL
    A0A1S5UZ16

  4. XM_054346066.1 → XP_054202041.1  target of Nesh-SH3 isoform X50

  5. XM_054346064.1 → XP_054202039.1  target of Nesh-SH3 isoform X48

  6. XM_054346062.1 → XP_054202037.1  target of Nesh-SH3 isoform X45

  7. XM_054346058.1 → XP_054202033.1  target of Nesh-SH3 isoform X41

  8. XM_054346056.1 → XP_054202031.1  target of Nesh-SH3 isoform X38

  9. XM_054346073.1 → XP_054202048.1  target of Nesh-SH3 isoform X57

    UniProtKB/TrEMBL
    A0A1S5UZ16

  10. XM_054346072.1 → XP_054202047.1  target of Nesh-SH3 isoform X56

    UniProtKB/TrEMBL
    A0A1S5UZ16

  11. XM_054346055.1 → XP_054202030.1  target of Nesh-SH3 isoform X36

  12. XM_054346049.1 → XP_054202024.1  target of Nesh-SH3 isoform X29

  13. XM_054346081.1 → XP_054202056.1  target of Nesh-SH3 isoform X65

    UniProtKB/TrEMBL
    A0A1S5UZ16

  14. XM_054346079.1 → XP_054202054.1  target of Nesh-SH3 isoform X63

    UniProtKB/TrEMBL
    A0A1S5UZ16

  15. XM_054346077.1 → XP_054202052.1  target of Nesh-SH3 isoform X61

    UniProtKB/TrEMBL
    A0A1S5UZ16

  16. XM_054346067.1 → XP_054202042.1  target of Nesh-SH3 isoform X51

  17. XM_054346053.1 → XP_054202028.1  target of Nesh-SH3 isoform X33

  18. XM_054346046.1 → XP_054202021.1  target of Nesh-SH3 isoform X20

  19. XM_054346074.1 → XP_054202049.1  target of Nesh-SH3 isoform X58

    UniProtKB/TrEMBL
    A0A1S5UZ16

  20. XM_054346065.1 → XP_054202040.1  target of Nesh-SH3 isoform X49

  21. XM_054346050.1 → XP_054202025.1  target of Nesh-SH3 isoform X30

  22. XM_054346061.1 → XP_054202036.1  target of Nesh-SH3 isoform X44

  23. XM_054346052.1 → XP_054202027.1  target of Nesh-SH3 isoform X32

  24. XM_054346047.1 → XP_054202022.1  target of Nesh-SH3 isoform X21

  25. XM_054346039.1 → XP_054202014.1  target of Nesh-SH3 isoform X7

  26. XM_054346078.1 → XP_054202053.1  target of Nesh-SH3 isoform X62

    UniProtKB/TrEMBL
    A0A1S5UZ16

  27. XM_054346082.1 → XP_054202057.1  target of Nesh-SH3 isoform X66

    UniProtKB/TrEMBL
    A0A1S5UZ16

  28. XM_054346076.1 → XP_054202051.1  target of Nesh-SH3 isoform X60

    UniProtKB/TrEMBL
    A0A1S5UZ16

  29. XM_054346075.1 → XP_054202050.1  target of Nesh-SH3 isoform X59

    UniProtKB/TrEMBL
    A0A1S5UZ16

  30. XM_054346063.1 → XP_054202038.1  target of Nesh-SH3 isoform X47

  31. XM_054346059.1 → XP_054202034.1  target of Nesh-SH3 isoform X42

  32. XM_054346043.1 → XP_054202018.1  target of Nesh-SH3 isoform X17

  33. XM_054346070.1 → XP_054202045.1  target of Nesh-SH3 isoform X54

    UniProtKB/TrEMBL
    A0A1S5UZ16

  34. XM_054346040.1 → XP_054202015.1  target of Nesh-SH3 isoform X8

  35. XM_054346071.1 → XP_054202046.1  target of Nesh-SH3 isoform X55

  36. XM_054346069.1 → XP_054202044.1  target of Nesh-SH3 isoform X53

    UniProtKB/TrEMBL
    A0A1S5UZ16

  37. XM_054346068.1 → XP_054202043.1  target of Nesh-SH3 isoform X52

  38. XM_054346060.1 → XP_054202035.1  target of Nesh-SH3 isoform X43

  39. XM_054346057.1 → XP_054202032.1  target of Nesh-SH3 isoform X40

  40. XM_054346048.1 → XP_054202023.1  target of Nesh-SH3 isoform X26

  41. XM_054346044.1 → XP_054202019.1  target of Nesh-SH3 isoform X18

  42. XM_054346038.1 → XP_054202013.1  target of Nesh-SH3 isoform X1

  43. XM_054346045.1 → XP_054202020.1  target of Nesh-SH3 isoform X19

  44. XM_054346054.1 → XP_054202029.1  target of Nesh-SH3 isoform X34

  45. XM_054346051.1 → XP_054202026.1  target of Nesh-SH3 isoform X31

  46. XM_054346042.1 → XP_054202017.1  target of Nesh-SH3 isoform X12

  47. XM_054346041.1 → XP_054202016.1  target of Nesh-SH3 isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z7G0.2 GenPept UniProtKB/Swiss-Prot:Q7Z7G0

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