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ZNF345 zinc finger protein 345 [ Homo sapiens (human) ]

Gene ID: 25850, updated on 9-Sep-2025
Official Symbol
ZNF345provided by HGNC
Official Full Name
zinc finger protein 345provided by HGNC
Primary source
HGNC:HGNC:16367
See related
Ensembl:ENSG00000251247 MIM:621272; AllianceGenome:HGNC:16367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF10
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Ubiquitous expression in testis (RPKM 2.1), skin (RPKM 1.8) and 25 other tissues See more
Orthologs
all
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See ZNF345 in Genome Data Viewer
Location:
19q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (36850365..36893218)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (39526030..39568903)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37341267..37384120)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ZNF850 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:37282721-37283221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14534 Neighboring gene ZNF790 antisense RNA 1 Neighboring gene zinc finger protein 790 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14535 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37368334-37369533 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:37382329-37383528 Neighboring gene zinc finger protein 829 Neighboring gene ribosomal protein L31 pseudogene 61 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14537 Neighboring gene zinc finger protein 568

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor. Moosmann P, et al. Biol Chem, 1997 Jul. PMID 9278146
  2. Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937. Abrink M, et al. DNA Cell Biol, 1995 Feb. PMID 7865130
  3. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
  4. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article
  5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36827, FLJ51247, FLJ96023, MGC33794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase III TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
involved_in transcription by RNA polymerase III TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 345
Names
zinc finger protein HZF10

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242472.2 → NP_001229401.1  zinc finger protein 345

    See identical proteins and their annotated locations for NP_001229401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AK315069, BC032863, DB289823
    Consensus CDS
    CCDS12497.1
    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000431216.1, ENST00000420450.6
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001242474.2 → NP_001229403.1  zinc finger protein 345

    See identical proteins and their annotated locations for NP_001229403.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AK315069, BC032863, BP195158, DB289823
    Consensus CDS
    CCDS12497.1
    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000431289.2, ENST00000532141.6
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001242475.2 → NP_001229404.1  zinc finger protein 345

    See identical proteins and their annotated locations for NP_001229404.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AC008733, BC032863, DB028175, DB289823
    Consensus CDS
    CCDS12497.1
    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000331120.5, ENST00000331800.9
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001242476.2 → NP_001229405.1  zinc finger protein 345

    See identical proteins and their annotated locations for NP_001229405.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AC008733, BC032863, DB028175, DB085650, DB289823
    Consensus CDS
    CCDS12497.1
    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000634032.1, ENST00000963973.1
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_003419.5 → NP_003410.1  zinc finger protein 345

    See identical proteins and their annotated locations for NP_003410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variants 2 through 5 encode the same protein.
    Source sequence(s)
    BC032863, DB096099, DB289823
    Consensus CDS
    CCDS12497.1
    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000465431.1, ENST00000589046.1
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_038362.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has alternate 5' and 3' sequences, compared to variant 1. The transcript does not have a supported open reading frame and therefore does not encode a protein.
    Source sequence(s)
    AC008733, DA625929

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    36850365..36893218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438566.1 → XP_047294522.1  zinc finger protein 345 isoform X1

    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000634034.1, ENST00000963975.1

  2. XM_017026568.2 → XP_016882057.1  zinc finger protein 345 isoform X1

    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000538577.1, ENST00000868518.1
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_017026573.2 → XP_016882062.1  zinc finger protein 345 isoform X1

    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000538572.1, ENST00000868513.1
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_017026569.3 → XP_016882058.1  zinc finger protein 345 isoform X1

    UniProtKB/Swiss-Prot
    Q14585
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_011526704.4 → XP_011525006.1  zinc finger protein 345 isoform X1

    See identical proteins and their annotated locations for XP_011525006.1

    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000538578.1, ENST00000868519.1
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_017026570.3 → XP_016882059.1  zinc finger protein 345 isoform X1

    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000538576.1, ENST00000868517.1
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_017026572.3 → XP_016882061.1  zinc finger protein 345 isoform X1

    UniProtKB/Swiss-Prot
    Q14585
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_017026571.3 → XP_016882060.1  zinc finger protein 345 isoform X1

    UniProtKB/Swiss-Prot
    Q14585
    Related
    ENSP00000584851.1, ENST00000914792.1
    Conserved Domains (2) summary
    COG5048
    Location:88 → 476
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    39526030..39568903
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320479.1 → XP_054176454.1  zinc finger protein 345 isoform X1

  2. XM_054320477.1 → XP_054176452.1  zinc finger protein 345 isoform X1

  3. XM_054320482.1 → XP_054176457.1  zinc finger protein 345 isoform X1

  4. XM_054320476.1 → XP_054176451.1  zinc finger protein 345 isoform X1

  5. XM_054320474.1 → XP_054176449.1  zinc finger protein 345 isoform X1

  6. XM_054320483.1 → XP_054176458.1  zinc finger protein 345 isoform X1

  7. XM_054320480.1 → XP_054176455.1  zinc finger protein 345 isoform X1

  8. XM_054320478.1 → XP_054176453.1  zinc finger protein 345 isoform X1

  9. XM_054320481.1 → XP_054176456.1  zinc finger protein 345 isoform X1

  10. XM_054320475.1 → XP_054176450.1  zinc finger protein 345 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14585.1 GenPept UniProtKB/Swiss-Prot:Q14585

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