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EML3 EMAP like 3 [ Homo sapiens (human) ]

Gene ID: 256364, updated on 7-Jun-2020

Summary

Official Symbol
EML3provided by HGNC
Official Full Name
EMAP like 3provided by HGNC
Primary source
HGNC:HGNC:26666
See related
Ensembl:ENSG00000149499 MIM:618118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ELP95; EMAP3; EMAP95
Expression
Ubiquitous expression in spleen (RPKM 13.3), fat (RPKM 13.0) and 25 other tissues See more
Orthologs

Genomic context

See EML3 in Genome Data Viewer
Location:
11q12.3
Exon count:
23
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62602218..62612775, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62369690..62380492, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene metastasis associated 1 family member 2 Neighboring gene retinal outer segment membrane protein 1 Neighboring gene beta-1,3-glucuronyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with echinoderm microtubule associated protein like 3 (EML3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35827, MGC111422

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
echinoderm microtubule-associated protein-like 3
Names
EMAP-3
echinoderm microtubule associated protein like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001300793.2NP_001287722.1  echinoderm microtubule-associated protein-like 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK093146, AP001458, BC050467, CN386216
    UniProtKB/Swiss-Prot
    Q32P44
    Related
    ENSP00000378256.4, ENST00000394776.8
    Conserved Domains (5) summary
    smart00320
    Location:300344
    WD40; WD40 repeats
    COG2319
    Location:348756
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:216285
    HELP; HELP motif
    sd00039
    Location:518556
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:399755
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001300794.2NP_001287723.1  echinoderm microtubule-associated protein-like 3 isoform 2

    See identical proteins and their annotated locations for NP_001287723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AK296901, AP001458, BC050467, CN386216, CN386217
    Consensus CDS
    CCDS76415.1
    UniProtKB/TrEMBL
    B4DL97
    Related
    ENSP00000434513.1, ENST00000529309.5
    Conserved Domains (5) summary
    smart00320
    Location:299343
    WD40; WD40 repeats
    COG2319
    Location:347755
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:215284
    HELP; HELP motif
    sd00039
    Location:517555
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:398754
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. NM_153265.3NP_694997.2  echinoderm microtubule-associated protein-like 3 isoform 3

    See identical proteins and their annotated locations for NP_694997.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon and differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) lacks a single alternate aa and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AP001458, BC050467, BC108280, CN386216, CN386217
    Consensus CDS
    CCDS8023.2
    UniProtKB/Swiss-Prot
    Q32P44
    Related
    ENSP00000378254.2, ENST00000394773.6
    Conserved Domains (3) summary
    sd00039
    Location:517555
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:215284
    HELP; HELP motif
    cl25539
    Location:551868
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62602218..62612775 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273878.4XP_005273935.1  echinoderm microtubule-associated protein-like 3 isoform X6

    See identical proteins and their annotated locations for XP_005273935.1

    UniProtKB/TrEMBL
    B7WPE2
    Related
    ENSP00000278845.4, ENST00000278845.8
    Conserved Domains (4) summary
    COG2319
    Location:514871
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:216285
    HELP; HELP motif
    sd00039
    Location:518556
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:552869
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_017017481.2XP_016872970.1  echinoderm microtubule-associated protein-like 3 isoform X7

  3. XM_017017480.1XP_016872969.1  echinoderm microtubule-associated protein-like 3 isoform X7

  4. XM_017017482.1XP_016872971.1  echinoderm microtubule-associated protein-like 3 isoform X8

    Related
    ENSP00000433417.1, ENST00000531557.5
    Conserved Domains (4) summary
    COG2319
    Location:397754
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:99168
    HELP; HELP motif
    sd00039
    Location:401439
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:435752
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  5. XM_006718489.4XP_006718552.1  echinoderm microtubule-associated protein-like 3 isoform X1

    Conserved Domains (5) summary
    smart00320
    Location:350394
    WD40; WD40 repeats
    COG2319
    Location:398806
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:266335
    HELP; HELP motif
    sd00039
    Location:568606
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:449805
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  6. XM_011544896.3XP_011543198.1  echinoderm microtubule-associated protein-like 3 isoform X2

    Conserved Domains (5) summary
    smart00320
    Location:349393
    WD40; WD40 repeats
    COG2319
    Location:397805
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:265334
    HELP; HELP motif
    sd00039
    Location:567605
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:448804
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  7. XM_006718491.4XP_006718554.1  echinoderm microtubule-associated protein-like 3 isoform X4

    Conserved Domains (4) summary
    COG2319
    Location:563920
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:265334
    HELP; HELP motif
    sd00039
    Location:567605
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:601918
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  8. XM_011544897.3XP_011543199.1  echinoderm microtubule-associated protein-like 3 isoform X5

    Conserved Domains (4) summary
    COG2319
    Location:352754
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:266335
    HELP; HELP motif
    sd00039
    Location:516554
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:350753
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  9. XM_006718490.4XP_006718553.1  echinoderm microtubule-associated protein-like 3 isoform X3

    Conserved Domains (4) summary
    COG2319
    Location:564921
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:266335
    HELP; HELP motif
    sd00039
    Location:568606
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:602919
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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