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Eml3 echinoderm microtubule associated protein like 3 [ Mus musculus (house mouse) ]

Gene ID: 225898, updated on 11-Apr-2024

Summary

Official Symbol
Eml3provided by MGI
Official Full Name
echinoderm microtubule associated protein like 3provided by MGI
Primary source
MGI:MGI:2387612
See related
Ensembl:ENSMUSG00000071647 AllianceGenome:MGI:2387612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emap-3
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization; mitotic metaphase plate congression; and regulation of mitotic spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including midbody; mitotic spindle microtubule; and nucleus. Predicted to colocalize with mitotic spindle. Orthologous to human EML3 (EMAP like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 29.9), spleen adult (RPKM 28.0) and 28 other tissues See more
Orthologs
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Genomic context

Location:
19 A; 19 6.04 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8904584..8918946)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8929663..8941582)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4265 Neighboring gene alpha glucosidase 2 alpha neutral subunit Neighboring gene STARR-seq mESC enhancer starr_45501 Neighboring gene predicted gene, 36629 Neighboring gene beta-1,3-glucuronyltransferase 3 Neighboring gene rod outer segment membrane protein 1 Neighboring gene predicted gene 10353 Neighboring gene STARR-positive B cell enhancer ABC_E5684 Neighboring gene metastasis-associated gene family, member 2 Neighboring gene STARR-positive B cell enhancer ABC_E11018 Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Clone Names

  • MGC37888, MGC38588

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mitotic metaphase chromosome alignment ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitotic spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
echinoderm microtubule-associated protein-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374671.1NP_001361600.1  echinoderm microtubule-associated protein-like 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129217, BC034112
    UniProtKB/TrEMBL
    A0A286YDN1
    Related
    ENSMUSP00000153500.2, ENSMUST00000224272.2
    Conserved Domains (3) summary
    sd00039
    Location:517555
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:215284
    HELP; HELP motif
    cl29593
    Location:551868
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_144872.1NP_659121.1  echinoderm microtubule-associated protein-like 3 isoform 1

    See identical proteins and their annotated locations for NP_659121.1

    Status: VALIDATED

    Source sequence(s)
    BC022146
    Consensus CDS
    CCDS29560.1
    UniProtKB/Swiss-Prot
    Q8R1S1, Q8VC03
    Related
    ENSMUSP00000093960.5, ENSMUST00000096241.6
    Conserved Domains (4) summary
    sd00039
    Location:518556
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:216285
    HELP; HELP motif
    cd21949
    Location:634
    TD_EMAP3; trimerization domain of echinoderm microtubule-associated protein-like 3
    cl29593
    Location:552869
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8904584..8918946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161541.1XP_036017434.1  echinoderm microtubule-associated protein-like 3 isoform X2

    Conserved Domains (3) summary
    sd00039
    Location:489527
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:187256
    HELP; HELP motif
    cl29593
    Location:523840
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_036161540.1XP_036017433.1  echinoderm microtubule-associated protein-like 3 isoform X1

    UniProtKB/Swiss-Prot
    Q8R1S1, Q8VC03
    Conserved Domains (4) summary
    sd00039
    Location:518556
    7WD40; WD40 repeat [structural motif]
    pfam03451
    Location:216285
    HELP; HELP motif
    cd21949
    Location:634
    TD_EMAP3; trimerization domain of echinoderm microtubule-associated protein-like 3
    cl29593
    Location:552869
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004940136.1 RNA Sequence

  2. XR_004940137.1 RNA Sequence