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ALOX5 arachidonate 5-lipoxygenase [ Homo sapiens (human) ]

Gene ID: 240, updated on 23-Nov-2021

Summary

Official Symbol
ALOX5provided by HGNC
Official Full Name
arachidonate 5-lipoxygenaseprovided by HGNC
Primary source
HGNC:HGNC:435
See related
Ensembl:ENSG00000012779 MIM:152390
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-LO; 5LPG; LOG5; 5-LOX
Summary
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Expression
Broad expression in bone marrow (RPKM 35.1), lung (RPKM 26.8) and 15 other tissues See more
Orthologs
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Genomic context

See ALOX5 in Genome Data Viewer
Location:
10q11.21
Exon count:
13
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (45374209..45446121)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45869664..45941565)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 6 subfamily D member 1 pseudogene Neighboring gene olfactory receptor family 13 subfamily A member 1 Neighboring gene uncharacterized LOC102724323 Neighboring gene uncharacterized LOC105378286 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene VISTA enhancer hs2065

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Asthma, susceptibility to
MedGen: C1869116 OMIM: 600807 GeneReviews: Not available
Compare labs
Discovery and refinement of loci associated with lipid levels.
GeneReviews: Not available
Genome-wide association study of hematological and biochemical traits in a Japanese population.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 downregulates the expression of arachidonate 5-lipoxygenase (ALOX5) in human B cells PubMed
env HIV-1 gp120 increases the intracellular concentrations of prostaglandin E2 and leukotriene B4 by upregulating the activity and expression of the arachidonate-metabolizing enzymes prostaglandin H synthase and 5-lipoxygenase, respectively PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163204

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendritic cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in humoral immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in leukocyte chemotaxis involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte migration involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in leukotriene A4 biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukotriene A4 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukotriene metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in leukotriene production involved in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipoxin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipoxygenase pathway TAS
Traceable Author Statement
more info
 
involved_in long-chain fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 
involved_in negative regulation of angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of endothelial cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of response to endoplasmic reticulum stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of sprouting angiogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of vascular wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of bone mineralization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cytokine production involved in inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response to wounding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of reactive oxygen species biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in extracellular space HDA PubMed 
located_in ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 
located_in nuclear envelope lumen IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
polyunsaturated fatty acid 5-lipoxygenase
Names
LOX-5
arachidonic acid 5-lipoxygenase
leukotriene A4 synthase
NP_000689.1
NP_001243082.1
NP_001243083.1
NP_001307790.1
NP_001307791.1
XP_016871501.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011437.1 RefSeqGene

    Range
    5036..76937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000698.5NP_000689.1  polyunsaturated fatty acid 5-lipoxygenase isoform 1

    See identical proteins and their annotated locations for NP_000689.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AW403395, BC132677
    Consensus CDS
    CCDS7212.1
    UniProtKB/Swiss-Prot
    P09917
    Related
    ENSP00000363512.2, ENST00000374391.7
    Conserved Domains (2) summary
    cd01753
    Location:2115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    cl27717
    Location:227665
    Lipoxygenase; Lipoxygenase
  2. NM_001256153.3NP_001243082.1  polyunsaturated fatty acid 5-lipoxygenase isoform 2

    See identical proteins and their annotated locations for NP_001243082.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK225603, AK315223, AW403395, BC132677
    UniProtKB/Swiss-Prot
    P09917
    Conserved Domains (2) summary
    cd01753
    Location:2115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:227633
    Lipoxygenase; Lipoxygenase
  3. NM_001256154.3NP_001243083.1  polyunsaturated fatty acid 5-lipoxygenase isoform 3

    See identical proteins and their annotated locations for NP_001243083.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AW403395, BC143985
    Consensus CDS
    CCDS58078.1
    UniProtKB/Swiss-Prot
    P09917
    Related
    ENSP00000437634.1, ENST00000542434.5
    Conserved Domains (2) summary
    cd01753
    Location:2115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:227608
    Lipoxygenase; Lipoxygenase
  4. NM_001320861.2NP_001307790.1  polyunsaturated fatty acid 5-lipoxygenase isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AL731567, AW403395, BC132677
    UniProtKB/Swiss-Prot
    P09917
    Conserved Domains (2) summary
    cd01753
    Location:2115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:227636
    Lipoxygenase; Lipoxygenase
  5. NM_001320862.2NP_001307791.1  polyunsaturated fatty acid 5-lipoxygenase isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at a downstream start site compared to variant 1. The encoded isoform (5) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AW403395, BC143986
    Conserved Domains (1) summary
    pfam00305
    Location:82520
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    45374209..45446121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016012.1XP_016871501.1  polyunsaturated fatty acid 5-lipoxygenase isoform X1

    Conserved Domains (1) summary
    pfam00305
    Location:82520
    Lipoxygenase; Lipoxygenase

RNA

  1. XR_001747075.1 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315935.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    215047..286948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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