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Alox5 arachidonate 5-lipoxygenase [ Mus musculus (house mouse) ]

Gene ID: 11689, updated on 18-Jan-2022

Summary

Official Symbol
Alox5provided by MGI
Official Full Name
arachidonate 5-lipoxygenaseprovided by MGI
Primary source
MGI:MGI:87999
See related
Ensembl:ENSMUSG00000025701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5LO; 5LX; 5-LO; 5-LOX; AI850497; F730011J02
Summary
Enables arachidonate 5-lipoxygenase activity. Involved in several processes, including leukocyte migration; negative regulation of angiogenesis; and regulation of cellular response to stress. Acts upstream of or within leukotriene biosynthetic process and leukotriene production involved in inflammatory response. Located in cytoplasm and nucleus. Is expressed in duodenum epithelium and small intestine epithelium. Human ortholog(s) of this gene implicated in artery disease (multiple); asthma (multiple); pancreatic cancer; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in lung adult (RPKM 3.4), heart adult (RPKM 2.7) and 22 other tissues See more
Orthologs
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Genomic context

See Alox5 in Genome Data Viewer
Location:
6 E3; 6 53.79 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (116387030..116438139, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (116410071..116461178, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (116360089..116411196, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger, AN1-type domain 4 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene predicted gene, 23527 Neighboring gene predicted gene, 38880 Neighboring gene olfactory receptor 211 Neighboring gene olfactory receptor 212

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arachidonate 5-lipoxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arachidonate 5-lipoxygenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arachidonate 5-lipoxygenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables arachidonate 5-lipoxygenase activity ISO
Inferred from Sequence Orthology
more info
 
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acute inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in dendritic cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hepoxilin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in humoral immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte chemotaxis involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte migration involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukotriene A4 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukotriene A4 biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukotriene biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within leukotriene biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukotriene biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukotriene biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within leukotriene metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within leukotriene production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid oxidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lipoxin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipoxygenase pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytochrome-c oxidase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of leukocyte adhesion to arterial endothelial cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of inflammatory response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope lumen ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
polyunsaturated fatty acid 5-lipoxygenase
Names
5-lipoxygenase
NP_033792.1
XP_036021653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009662.2NP_033792.1  polyunsaturated fatty acid 5-lipoxygenase

    See identical proteins and their annotated locations for NP_033792.1

    Status: VALIDATED

    Source sequence(s)
    AK171413, BY205433, BY555055
    Consensus CDS
    CCDS20452.1
    UniProtKB/Swiss-Prot
    P48999
    Related
    ENSMUSP00000026795.7, ENSMUST00000026795.13
    Conserved Domains (2) summary
    cd01753
    Location:2115
    PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
    pfam00305
    Location:224665
    Lipoxygenase; Lipoxygenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    116387030..116438139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165760.1XP_036021653.1  polyunsaturated fatty acid 5-lipoxygenase isoform X1

    Conserved Domains (1) summary
    pfam00305
    Location:36480
    Lipoxygenase
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