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PRKD3 protein kinase D3 [ Homo sapiens (human) ]

Gene ID: 23683, updated on 1-Jun-2020

Summary

Official Symbol
PRKD3provided by HGNC
Official Full Name
protein kinase D3provided by HGNC
Primary source
HGNC:HGNC:9408
See related
Ensembl:ENSG00000115825 MIM:607077
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EPK2; PKD3; PRKCN; PKC-NU; nPKC-NU
Summary
This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in lymph node (RPKM 16.0), testis (RPKM 14.3) and 25 other tissues See more
Orthologs

Genomic context

See PRKD3 in Genome Data Viewer
Location:
2p22.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (37250502..37324833, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (37477645..37551915, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sulfotransferase family 6B member 1 Neighboring gene ribosomal protein L31 pseudogene 16 Neighboring gene CEBPZ opposite strand Neighboring gene CCAAT enhancer binding protein zeta Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene uncharacterized LOC101929542 Neighboring gene RNA, U6 small nuclear 939, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Protein kinase C is required for HIV-1 Tat-mediated transactivation of the viral LTR promoter, indicating protein kinase C regulates the process of HIV-1 transactivation and may play a role in the transition of HIV from latency to productive growth PubMed
tat Protein kinase C phosphorylates HIV-1 Tat on serine residue 46 PubMed
tat HIV-1 Tat activates protein kinase C, resulting in the induction of TNF-alpha, IL-6 and IL-10 expression and the secretion of MCP-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
calcium-dependent protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein kinase C-activating G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
protein kinase D signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
sphingolipid biosynthetic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase D3
Names
protein kinase C nu type
protein kinase EPK2
NP_005804.1
XP_005264294.1
XP_005264295.1
XP_016859230.1
XP_016859231.1
XP_016859232.1
XP_016859233.1
XP_024308545.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005813.6NP_005804.1  serine/threonine-protein kinase D3

    See identical proteins and their annotated locations for NP_005804.1

    Status: REVIEWED

    Source sequence(s)
    AC007390, AC007391
    Consensus CDS
    CCDS1789.1
    UniProtKB/Swiss-Prot
    O94806
    Related
    ENSP00000234179.2, ENST00000234179.7
    Conserved Domains (4) summary
    cd00029
    Location:272321
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:410534
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:572831
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:159204
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    37250502..37324833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264237.4XP_005264294.1  serine/threonine-protein kinase D3 isoform X1

    See identical proteins and their annotated locations for XP_005264294.1

    UniProtKB/Swiss-Prot
    O94806
    Conserved Domains (4) summary
    cd00029
    Location:272321
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:410534
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:572831
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:159204
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  2. XM_005264238.3XP_005264295.1  serine/threonine-protein kinase D3 isoform X2

    See identical proteins and their annotated locations for XP_005264295.1

    Conserved Domains (5) summary
    smart00220
    Location:476728
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:168217
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:306430
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:468727
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:55100
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  3. XM_017003741.2XP_016859230.1  serine/threonine-protein kinase D3 isoform X3

    Conserved Domains (5) summary
    smart00220
    Location:407659
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:99148
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:237361
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:399658
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:131
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  4. XM_017003742.2XP_016859231.1  serine/threonine-protein kinase D3 isoform X3

    Conserved Domains (5) summary
    smart00220
    Location:407659
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00029
    Location:99148
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:237361
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:399658
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00130
    Location:131
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
  5. XM_024452777.1XP_024308545.1  serine/threonine-protein kinase D3 isoform X4

    Conserved Domains (3) summary
    cd00029
    Location:1362
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:151275
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:313572
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
  6. XM_017003743.2XP_016859232.1  serine/threonine-protein kinase D3 isoform X4

    Conserved Domains (3) summary
    cd00029
    Location:1362
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:151275
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:313572
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
  7. XM_017003744.2XP_016859233.1  serine/threonine-protein kinase D3 isoform X4

    Conserved Domains (3) summary
    cd00029
    Location:1362
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:151275
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:313572
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
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