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NUP62 nucleoporin 62 [ Homo sapiens (human) ]

Gene ID: 23636, updated on 7-Jun-2020

Summary

Official Symbol
NUP62provided by HGNC
Official Full Name
nucleoporin 62provided by HGNC
Primary source
HGNC:HGNC:8066
See related
Ensembl:ENSG00000213024 MIM:605815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p62; IBSN; SNDI
Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 21.4), appendix (RPKM 16.1) and 25 other tissues See more
Orthologs

Genomic context

See NUP62 in Genome Data Viewer
Location:
19q13.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49906825..49929504, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50410082..50432988, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AKT1 substrate 1 Neighboring gene TBC1 domain family member 17 Neighboring gene microRNA 4750 Neighboring gene interleukin 4 induced 1 Neighboring gene activating transcription factor 5 Neighboring gene microRNA 4751 Neighboring gene sialic acid binding Ig like lectin 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleoporin 62kDa (NUP62) by shRNA inhibits HIV-1 infection by reducing viral DNA integration in CD4+ C8166 T cells and macrophages PubMed
Knockdown of nucleoporin 62kDa (NUP62) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev nup62 is involved in Rev-mediated nuclear export of HIV-1 mRNA through an interaction with eukaryotic initiation factor 5A (eIF-5A) which binds to Rev PubMed
integrase gag-pol HIV-1 IN specifically binds NUP62 through the IN binding domain (residues 328-522) of NUP62 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC841, FLJ20822, FLJ43869, DKFZp547L134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
PTB domain binding IEA
Inferred from Electronic Annotation
more info
 
SH2 domain binding IDA
Inferred from Direct Assay
more info
 
chromatin binding NAS
Non-traceable Author Statement
more info
 
kinesin binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
receptor signaling complex scaffold activity IDA
Inferred from Direct Assay
more info
 
structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
thyroid hormone receptor binding IPI
Inferred from Physical Interaction
more info
 
ubiquitin binding IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell aging IEA
Inferred from Electronic Annotation
more info
 
cell death IMP
Inferred from Mutant Phenotype
more info
 
cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
 
centriole assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone-mediated signaling pathway NAS
Non-traceable Author Statement
more info
 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
mRNA export from nucleus TAS
Traceable Author Statement
more info
 
mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 
negative regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of programmed cell death IDA
Inferred from Direct Assay
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
 
positive regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of epidermal growth factor receptor signaling pathway NAS
Non-traceable Author Statement
more info
 
positive regulation of mitotic cytokinetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 
protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein sumoylation TAS
Traceable Author Statement
more info
 
regulation of Ras protein signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of gene silencing by miRNA TAS
Traceable Author Statement
more info
 
regulation of glycolytic process TAS
Traceable Author Statement
more info
 
regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction NAS
Non-traceable Author Statement
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
tRNA export from nucleus TAS
Traceable Author Statement
more info
 
transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 
viral process TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Flemming body IDA
Inferred from Direct Assay
more info
PubMed 
annulate lamellae IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
 
host cell IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope TAS
Traceable Author Statement
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear pore glycoprotein p62
Names
62 kDa nucleoporin
nucleoporin 62kD
nucleoporin 62kDa
nucleoporin Nup62

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023448.1 RefSeqGene

    Range
    5228..27907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193357.2NP_001180286.1  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_001180286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BG575286, BM672281, DB076767
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    cl25599
    Location:2251
    Nucleoporin_FG2; Nucleoporin FG repeated region
  2. NM_012346.5NP_036478.2  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_036478.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BG575286, BM672281, DA856902
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    cl25599
    Location:2251
    Nucleoporin_FG2; Nucleoporin FG repeated region
  3. NM_016553.5NP_057637.2  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_057637.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BG575286, BM672281, DA949331
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Related
    ENSP00000305503.2, ENST00000352066.7
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    cl25599
    Location:2251
    Nucleoporin_FG2; Nucleoporin FG repeated region
  4. NM_153718.4NP_714940.1  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_714940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BG575286, BM672281, DA438104
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Related
    ENSP00000407331.1, ENST00000422090.2
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    cl25599
    Location:2251
    Nucleoporin_FG2; Nucleoporin FG repeated region
  5. NM_153719.4NP_714941.1  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_714941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BC101107, BG575286, BM672281, DA945913
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Related
    ENSP00000473192.1, ENST00000597029.5
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    cl25599
    Location:2251
    Nucleoporin_FG2; Nucleoporin FG repeated region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49906825..49929504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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