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NUP62 nucleoporin 62 [ Homo sapiens (human) ]

Gene ID: 23636, updated on 5-Sep-2021

Summary

Official Symbol
NUP62provided by HGNC
Official Full Name
nucleoporin 62provided by HGNC
Primary source
HGNC:HGNC:8066
See related
Ensembl:ENSG00000213024 MIM:605815
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p62; IBSN; SNDI
Summary
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 21.4), appendix (RPKM 16.1) and 25 other tissues See more
Orthologs
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Genomic context

See NUP62 in Genome Data Viewer
Location:
19q13.33
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49906825..49929504, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (50410082..50432761, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene AKT1 substrate 1 Neighboring gene TBC1 domain family member 17 Neighboring gene microRNA 4750 Neighboring gene interleukin 4 induced 1 Neighboring gene activating transcription factor 5 Neighboring gene microRNA 4751 Neighboring gene sialic acid binding Ig like lectin 11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of nucleoporin 62kDa (NUP62) by shRNA inhibits HIV-1 infection by reducing viral DNA integration in CD4+ C8166 T cells and macrophages PubMed
Knockdown of nucleoporin 62kDa (NUP62) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Rev rev nup62 is involved in Rev-mediated nuclear export of HIV-1 mRNA through an interaction with eukaryotic initiation factor 5A (eIF-5A) which binds to Rev PubMed
integrase gag-pol HIV-1 IN specifically binds NUP62 through the IN binding domain (residues 328-522) of NUP62 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC841, FLJ20822, FLJ43869, DKFZp547L134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables Hsp90 protein binding IEA
Inferred from Electronic Annotation
more info
 
enables PTB domain binding IEA
Inferred from Electronic Annotation
more info
 
enables SH2 domain binding IDA
Inferred from Direct Assay
more info
 
enables chromatin binding NAS
Non-traceable Author Statement
more info
 
enables kinesin binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor complex adaptor activity IDA
Inferred from Direct Assay
more info
 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
involved_in RNA export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell aging IEA
Inferred from Electronic Annotation
more info
 
involved_in cell death IMP
Inferred from Mutant Phenotype
more info
 
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell surface receptor signaling pathway NAS
Non-traceable Author Statement
more info
 
involved_in centriole assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic metaphase plate congression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of MAP kinase activity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of programmed cell death IDA
Inferred from Direct Assay
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
 
involved_in positive regulation of centriole replication IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway NAS
Non-traceable Author Statement
more info
 
involved_in positive regulation of mitotic cytokinetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
 
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of Ras protein signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of mitotic spindle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein import into nucleus IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of signal transduction NAS
Non-traceable Author Statement
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Flemming body IDA
Inferred from Direct Assay
more info
PubMed 
located_in annulate lamellae IEA
Inferred from Electronic Annotation
more info
 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear envelope TAS
Traceable Author Statement
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
part_of nuclear pore IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nuclear pore glycoprotein p62
Names
62 kDa nucleoporin
nucleoporin 62kD
nucleoporin 62kDa
nucleoporin Nup62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023448.1 RefSeqGene

    Range
    5228..27907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193357.2NP_001180286.1  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_001180286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BG575286, BM672281, DB076767
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    pfam15967
    Location:1255
    Nucleoporin_FG2; Nucleoporin FG repeated region
  2. NM_012346.5NP_036478.2  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_036478.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BG575286, BM672281, DA856902
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    pfam15967
    Location:1255
    Nucleoporin_FG2; Nucleoporin FG repeated region
  3. NM_016553.5NP_057637.2  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_057637.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BG575286, BM672281, DA949331
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Related
    ENSP00000305503.3, ENST00000352066.8
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    pfam15967
    Location:1255
    Nucleoporin_FG2; Nucleoporin FG repeated region
  4. NM_153718.4NP_714940.1  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_714940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BG575286, BM672281, DA438104
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Related
    ENSP00000407331.1, ENST00000422090.2
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    pfam15967
    Location:1255
    Nucleoporin_FG2; Nucleoporin FG repeated region
  5. NM_153719.4NP_714941.1  nuclear pore glycoprotein p62

    See identical proteins and their annotated locations for NP_714941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants encode the same protein.
    Source sequence(s)
    AL162061, BC050717, BC101107, BG575286, BM672281, DA945913
    Consensus CDS
    CCDS12788.1
    UniProtKB/Swiss-Prot
    P37198
    UniProtKB/TrEMBL
    A0A024QZF1
    Related
    ENSP00000473192.1, ENST00000597029.5
    Conserved Domains (3) summary
    pfam05064
    Location:328429
    Nsp1_C; Nsp1-like C-terminal region
    pfam13851
    Location:367512
    GAS; Growth-arrest specific micro-tubule binding
    pfam15967
    Location:1255
    Nucleoporin_FG2; Nucleoporin FG repeated region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49906825..49929504 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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