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MKRN2 makorin ring finger protein 2 [ Homo sapiens (human) ]

Gene ID: 23609, updated on 24-Nov-2020

Summary

Official Symbol
MKRN2provided by HGNC
Official Full Name
makorin ring finger protein 2provided by HGNC
Primary source
HGNC:HGNC:7113
See related
Ensembl:ENSG00000075975 MIM:608426
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF62; HSPC070
Summary
This gene encodes a probable E3 ubiquitin ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Ubiquitous expression in testis (RPKM 30.6), thyroid (RPKM 16.5) and 25 other tissues See more
Orthologs

Genomic context

See MKRN2 in Genome Data Viewer
Location:
3p25.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (12557087..12583713)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (12598513..12625212)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene RNA, 5S ribosomal pseudogene 123 Neighboring gene RNA, U6 small nuclear 377, pseudogene Neighboring gene MKRN2 opposite strand Neighboring gene Raf-1 proto-oncogene, serine/threonine kinase Neighboring gene cysteine rich protein 1 pseudogene 1 Neighboring gene transmembrane protein 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of makorin ring finger protein 2 (MKRN2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase makorin-2
Names
RING finger protein 62
RING-type E3 ubiquitin transferase makorin-2
makorin RING zinc-finger protein 2
NP_001258636.1
NP_054879.3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271707.2NP_001258636.1  probable E3 ubiquitin-protein ligase makorin-2 isoform 2

    See identical proteins and their annotated locations for NP_001258636.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AK298463, BC015715
    Consensus CDS
    CCDS63545.1
    UniProtKB/Swiss-Prot
    Q9H000
    Related
    ENSP00000396340.1, ENST00000411987.5
    Conserved Domains (2) summary
    PHA03096
    Location:135284
    PHA03096; p28-like protein; Provisional
    cd00162
    Location:195249
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_014160.5NP_054879.3  probable E3 ubiquitin-protein ligase makorin-2 isoform 1

    See identical proteins and their annotated locations for NP_054879.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK298463, BC015715
    Consensus CDS
    CCDS33702.1
    UniProtKB/Swiss-Prot
    Q9H000
    Related
    ENSP00000170447.7, ENST00000170447.12
    Conserved Domains (3) summary
    smart00356
    Location:3555
    ZnF_C3H1; zinc finger
    PHA03096
    Location:178327
    PHA03096; p28-like protein; Provisional
    cd00162
    Location:238292
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    12557087..12583713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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