1FBV,1CHC,1JM7,1RMD,1G25


Conserved Protein Domain Family
RING

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cd00162: RING (this model, PSSM-Id:238093 is obsolete and has been replaced by 319361)
Click on image for an interactive view with Cn3D
RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in mediating protein-protein interactions; identified in a proteins with a wide range of functions such as viral replication, signal transduction, and development; has two variants, the C3HC4-type and a C3H2C3-type (RING-H2 finger), which have different cysteine/histidine pattern; a subset of RINGs are associated with B-Boxes (C-X2-H-X7-C-X7-C-X2-C-H-X2-H)
Statistics
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PSSM-Id: 238093
View PSSM: cd00162
Aligned: 555 rows
Threshold Bit Score: 28.9508
Threshold Setting Gi: 2078309
Created: 1-Nov-2000
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
 
cross-brace
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:cross-brace motif
Evidence:
  • Comment:C-X(2)-C-X(9,39)-C-X(1,3)-H-X(2,3)-[NCH]-X(2)-C-X(4,48)-C-X(2)-C.
  • Comment:specialized type of zinc-finger
  • Citation:PMID 8744354
  • Structure:binds two zinc ions
    View structure with Cn3D

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
Feature 1         #  #                    # #   #  #                  #  #    
1FBV_A       334 LCKICAEnd---------kDVKIEpCGHL-MCTSCLTSWqes-------egqGCPFCRCEI 377
gi 3618207    80 ICFICAEgi--------tySCVLP-CNHR-MCHVCALRLraly------ktkECTFCKTEW 124
gi 14248546  298 ICKICYSee---------rNVCFVpCGHVvACAKCALSTd------------KCPMCRRTF 337
gi 13905182  329 PCPICARql--------gkQWAVLtCGHC-FCNECTSIIieqysvgshrssiKCAICRQTT 380
gi 2497243   390 LCKICYGae---------yNTAFLpCGHVvACAKCASSVt------------KCPLCRKPF 429
gi 8920629   652 ECIICMKde---------vSVVFLpCAHQvVCGSCSDSFfasnn---ggskvTCPCCRGRE 700
gi 16740774  823 KCSICNSale-------lpSVHFL-CGHS-FHQHCFESYses--------daDCPTCLPEN 866
gi 15218791  767 ECVMCLSee---------mSVIFLpCAHQvLCFKCNQLHeke-------gmmDCPSCRGTI 811
gi 418248    206 LCHICSCtftdiqnynsnfVTSTE-CNHA-VCFKCYVSIvfgk------esyKCSICNRTT 258
gi 1353157   772 KCSACDTplq-------lpTVHFL-CKHA-YHVHCFESYnmd-------gsdKCPACQTTR 816

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