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Mkrn2 makorin, ring finger protein, 2 [ Mus musculus (house mouse) ]

Gene ID: 67027, updated on 12-May-2024

Summary

Official Symbol
Mkrn2provided by MGI
Official Full Name
makorin, ring finger protein, 2provided by MGI
Primary source
MGI:MGI:1914277
See related
Ensembl:ENSMUSG00000000439 AllianceGenome:MGI:1914277
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610002L04Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in early conceptus and genitourinary system. Orthologous to human MKRN2 (makorin ring finger protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 33.7), adrenal adult (RPKM 19.9) and 28 other tissues See more
Orthologs
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Genomic context

See Mkrn2 in Genome Data Viewer
Location:
6 E3; 6 53.61 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (115578844..115598647)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (115601883..115621683)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115510052-115510235 Neighboring gene STARR-seq mESC enhancer starr_17082 Neighboring gene STARR-positive B cell enhancer mm9_chr6:115533495-115533796 Neighboring gene makorin, ring finger protein 2, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115551710-115551893 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:115570008-115570117 Neighboring gene v-raf-leukemia viral oncogene 1 Neighboring gene TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor pseudogene Neighboring gene STARR-seq mESC enhancer starr_17084 Neighboring gene RIKEN cDNA D830050J10 gene Neighboring gene STARR-positive B cell enhancer ABC_E10401

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase makorin-2
Names
Makorin RING zinc-finger protein 2
RING-type E3 ubiquitin transferase makorin-2
probable E3 ubiquitin-protein ligase makorin-2
NP_075779.2
XP_011239733.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023290.3NP_075779.2  E3 ubiquitin-protein ligase makorin-2

    See identical proteins and their annotated locations for NP_075779.2

    Status: VALIDATED

    Source sequence(s)
    AC160032
    Consensus CDS
    CCDS39600.1
    UniProtKB/Swiss-Prot
    Q6GTY9, Q9D0L9, Q9ERV1
    UniProtKB/TrEMBL
    Q9D776
    Related
    ENSMUSP00000000449.8, ENSMUST00000000449.9
    Conserved Domains (3) summary
    smart00356
    Location:3555
    ZnF_C3H1; zinc finger
    PHA03096
    Location:178327
    PHA03096; p28-like protein; Provisional
    cd00162
    Location:238292
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    115578844..115598647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241431.3XP_011239733.1  E3 ubiquitin-protein ligase makorin-2 isoform X1

    Conserved Domains (2) summary
    COG5252
    Location:102175
    COG5252; Uncharacterized conserved protein, contains CCCH-type Zn-finger protein [General function prediction only]
    cd16731
    Location:3794
    RING-HC_MKRN2; RING finger, HC subclass, found in makorin-2 (MKRN2) and similar proteins