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SUN1 Sad1 and UNC84 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 23353, updated on 8-Jul-2019

Summary

Official Symbol
SUN1provided by HGNC
Official Full Name
Sad1 and UNC84 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:18587
See related
Ensembl:ENSG00000164828 MIM:607723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC84A
Summary
This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2019]
Expression
Ubiquitous expression in endometrium (RPKM 45.0), skin (RPKM 41.1) and 25 other tissues See more
Orthologs

Genomic context

See SUN1 in Genome Data Viewer
Location:
7p22.3
Exon count:
30
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (815557..874934)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (855194..914557)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene protein kinase cAMP-dependent type I regulatory subunit beta Neighboring gene uncharacterized LOC105375119 Neighboring gene dynein axonemal assembly factor 5 Neighboring gene guided entry of tail-anchored proteins factor 4 Neighboring gene ArfGAP with dual PH domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 is identified to have a physical interaction with Sad1 and UNC84 domain containing 1 (SUN1; UNC84A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Meiosis, organism-specific biosystem (from REACTOME)
    Meiosis, organism-specific biosystemDuring meiosis the replicated chromosomes of a single diploid cell are segregated into 4 haploid daughter cells by two successive divisions, meiosis I and meiosis II. In meiosis I, the distinguishing...
  • Meiotic synapsis, organism-specific biosystem (from REACTOME)
    Meiotic synapsis, organism-specific biosystemMeiotic synapsis is the stable physical pairing of homologous chromosomes that begins in leptonema of prophase I and lasts until anaphase of prophase I. First, short segments of axial elements form a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GET4

Homology

Clone Names

  • FLJ12407, KIAA0810, MGC176649

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lamin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein membrane anchor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
centrosome localization IEA
Inferred from Electronic Annotation
more info
 
cytoskeletal anchoring at nuclear membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoskeletal anchoring at nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
meiotic attachment of telomere to nuclear envelope IEA
Inferred from Electronic Annotation
more info
 
nuclear envelope organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope organization IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear matrix anchoring at nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration IEA
Inferred from Electronic Annotation
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
synapsis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
meiotic nuclear membrane microtubule tethering complex IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear envelope IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
SUN domain-containing protein 1
Names
Sad1 unc-84 domain protein 1
protein unc-84 homolog A
sad1/unc-84 protein-like 1
unc-84 homolog A

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130965.3NP_001124437.1  SUN domain-containing protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 72, and 73 all encode the same isoform (a).
    Source sequence(s)
    AB018353, AC099731, AK022816, BM689998
    Consensus CDS
    CCDS47525.1
    UniProtKB/Swiss-Prot
    O94901
    Related
    ENSP00000384015.1, ENST00000401592.6
    Conserved Domains (3) summary
    pfam07738
    Location:648783
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:72291
    MRP; Mitochondrial RNA binding protein MRP
    pfam16043
    Location:439555
    DUF4795; Domain of unknown function (DUF4795)
  2. NM_001171944.2NP_001165415.1  SUN domain-containing protein 1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks three in-frame exons in the middle portion of the coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS55080.1
    UniProtKB/Swiss-Prot
    O94901
    Related
    ENSP00000413439.2, ENST00000452783.6
    Conserved Domains (3) summary
    pfam07738
    Location:545680
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:72189
    MRP; Mitochondrial RNA binding protein MRP
    pfam16043
    Location:336452
    DUF4795; Domain of unknown function (DUF4795)
  3. NM_001171945.2NP_001165416.1  SUN domain-containing protein 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences compared to variant 1. These differences result in distinct 5' and 3' UTRs and cause translation initiation at an alternate, upstream start codon, compared to variant 1. The encoded protein (isoform d) is shorter than isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS55078.1
    UniProtKB/Swiss-Prot
    O94901
    Related
    ENSP00000395952.2, ENST00000457378.6
    Conserved Domains (1) summary
    pfam09387
    Location:93269
    MRP; Mitochondrial RNA binding protein MRP
  4. NM_001171946.2NP_001165417.1  SUN domain-containing protein 1 isoform e

    See identical proteins and their annotated locations for NP_001165417.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS55079.1
    UniProtKB/Swiss-Prot
    O94901
    Related
    ENSP00000383947.1, ENST00000403868.5
    Conserved Domains (1) summary
    pfam09387
    Location:72248
    MRP; Mitochondrial RNA binding protein MRP
  5. NM_001367633.1NP_001354562.1  SUN domain-containing protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (73), as well as variants 1 and 72, encodes isoform a.
    Source sequence(s)
    AC099731
  6. NM_001367634.1NP_001354563.1  SUN domain-containing protein 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (72), as well as variants 1 and 73, encodes isoform a.
    Source sequence(s)
    AC099731
  7. NM_001367635.1NP_001354564.1  SUN domain-containing protein 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC099731
  8. NM_001367636.1NP_001354565.1  SUN domain-containing protein 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC099731
  9. NM_001367637.1NP_001354566.1  SUN domain-containing protein 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC099731
  10. NM_001367638.1NP_001354567.1  SUN domain-containing protein 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC099731
  11. NM_001367639.1NP_001354568.1  SUN domain-containing protein 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC099731
    Related
    ENSP00000406653.1, ENST00000433212.5
  12. NM_001367640.1NP_001354569.1  SUN domain-containing protein 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC099731
  13. NM_001367641.1NP_001354570.1  SUN domain-containing protein 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC099731
  14. NM_001367642.1NP_001354571.1  SUN domain-containing protein 1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AC099731
  15. NM_001367643.1NP_001354572.1  SUN domain-containing protein 1 isoform n

    Status: REVIEWED

    Source sequence(s)
    AC099731
  16. NM_001367644.1NP_001354573.1  SUN domain-containing protein 1 isoform o

    Status: REVIEWED

    Source sequence(s)
    AC099731
  17. NM_001367645.1NP_001354574.1  SUN domain-containing protein 1 isoform p

    Status: REVIEWED

    Source sequence(s)
    AC099731
  18. NM_001367646.1NP_001354575.1  SUN domain-containing protein 1 isoform q

    Status: REVIEWED

    Source sequence(s)
    AC099731
  19. NM_001367647.1NP_001354576.1  SUN domain-containing protein 1 isoform r

    Status: REVIEWED

    Source sequence(s)
    AC099731
  20. NM_001367648.1NP_001354577.1  SUN domain-containing protein 1 isoform s

    Status: REVIEWED

    Source sequence(s)
    AC099731
  21. NM_001367649.1NP_001354578.1  SUN domain-containing protein 1 isoform t

    Status: REVIEWED

    Source sequence(s)
    AC099731
  22. NM_001367651.1NP_001354580.1  SUN domain-containing protein 1 isoform u

    Status: REVIEWED

    Source sequence(s)
    AC099731
  23. NM_001367653.1NP_001354582.1  SUN domain-containing protein 1 isoform v

    Status: REVIEWED

    Source sequence(s)
    AC099731
  24. NM_001367655.1NP_001354584.1  SUN domain-containing protein 1 isoform w

    Status: REVIEWED

    Source sequence(s)
    AC099731
  25. NM_001367658.1NP_001354587.1  SUN domain-containing protein 1 isoform x

    Status: REVIEWED

    Source sequence(s)
    AC099731
  26. NM_001367660.1NP_001354589.1  SUN domain-containing protein 1 isoform y

    Status: REVIEWED

    Source sequence(s)
    AC099731
  27. NM_001367662.1NP_001354591.1  SUN domain-containing protein 1 isoform z

    Status: REVIEWED

    Source sequence(s)
    AC099731
  28. NM_001367664.1NP_001354593.1  SUN domain-containing protein 1 isoform aa

    Status: REVIEWED

    Source sequence(s)
    AC099731
    Related
    ENSP00000384116.1, ENST00000405266.5
  29. NM_001367665.1NP_001354594.1  SUN domain-containing protein 1 isoform bb

    Status: REVIEWED

    Source sequence(s)
    AC099731
  30. NM_001367666.1NP_001354595.1  SUN domain-containing protein 1 isoform cc

    Status: REVIEWED

    Source sequence(s)
    AC099731
  31. NM_001367667.1NP_001354596.1  SUN domain-containing protein 1 isoform dd

    Status: REVIEWED

    Source sequence(s)
    AC099731
  32. NM_001367668.1NP_001354597.1  SUN domain-containing protein 1 isoform ee

    Status: REVIEWED

    Source sequence(s)
    AC099731
  33. NM_001367669.1NP_001354598.1  SUN domain-containing protein 1 isoform ff

    Status: REVIEWED

    Source sequence(s)
    AC099731
  34. NM_001367670.1NP_001354599.1  SUN domain-containing protein 1 isoform gg

    Status: REVIEWED

    Source sequence(s)
    AC099731
  35. NM_001367671.1NP_001354600.1  SUN domain-containing protein 1 isoform hh

    Status: REVIEWED

    Source sequence(s)
    AC099731
  36. NM_001367672.1NP_001354601.1  SUN domain-containing protein 1 isoform ii

    Status: REVIEWED

    Source sequence(s)
    AC099731
  37. NM_001367673.1NP_001354602.1  SUN domain-containing protein 1 isoform jj

    Status: REVIEWED

    Source sequence(s)
    AC099731
    Related
    ENSP00000409909.1, ENST00000429178.5
  38. NM_001367674.1NP_001354603.1  SUN domain-containing protein 1 isoform kk

    Status: REVIEWED

    Source sequence(s)
    AC099731
  39. NM_001367675.1NP_001354604.1  SUN domain-containing protein 1 isoform ll

    Status: REVIEWED

    Source sequence(s)
    AC099731
  40. NM_001367676.1NP_001354605.1  SUN domain-containing protein 1 isoform mm

    Status: REVIEWED

    Source sequence(s)
    AC099731
  41. NM_001367677.1NP_001354606.1  SUN domain-containing protein 1 isoform nn

    Status: REVIEWED

    Source sequence(s)
    AC099731
  42. NM_001367678.1NP_001354607.1  SUN domain-containing protein 1 isoform oo

    Status: REVIEWED

    Source sequence(s)
    AC099731
  43. NM_001367679.1NP_001354608.1  SUN domain-containing protein 1 isoform pp

    Status: REVIEWED

    Source sequence(s)
    AC099731
  44. NM_001367680.1NP_001354609.1  SUN domain-containing protein 1 isoform qq

    Status: REVIEWED

    Source sequence(s)
    AC099731
  45. NM_001367681.1NP_001354610.1  SUN domain-containing protein 1 isoform rr

    Status: REVIEWED

    Source sequence(s)
    AC099731
  46. NM_001367682.1NP_001354611.1  SUN domain-containing protein 1 isoform ss

    Status: REVIEWED

    Source sequence(s)
    AC099731
  47. NM_001367683.1NP_001354612.1  SUN domain-containing protein 1 isoform tt

    Status: REVIEWED

    Source sequence(s)
    AC099731
  48. NM_001367684.1NP_001354613.1  SUN domain-containing protein 1 isoform uu

    Status: REVIEWED

    Source sequence(s)
    AC099731
  49. NM_001367685.1NP_001354614.1  SUN domain-containing protein 1 isoform vv

    Status: REVIEWED

    Source sequence(s)
    AC099731
  50. NM_001367686.1NP_001354615.1  SUN domain-containing protein 1 isoform ww

    Status: REVIEWED

    Source sequence(s)
    AC099731
  51. NM_001367687.1NP_001354616.1  SUN domain-containing protein 1 isoform xx

    Status: REVIEWED

    Source sequence(s)
    AC099731
  52. NM_001367688.1NP_001354617.1  SUN domain-containing protein 1 isoform yy

    Status: REVIEWED

    Source sequence(s)
    AC099731
  53. NM_001367689.1NP_001354618.1  SUN domain-containing protein 1 isoform zz

    Status: REVIEWED

    Source sequence(s)
    AC099731
  54. NM_001367690.1NP_001354619.1  SUN domain-containing protein 1 isoform aaa

    Status: REVIEWED

    Source sequence(s)
    AC099731
  55. NM_001367691.1NP_001354620.1  SUN domain-containing protein 1 isoform bbb

    Status: REVIEWED

    Source sequence(s)
    AC099731
  56. NM_001367692.1NP_001354621.1  SUN domain-containing protein 1 isoform ccc

    Status: REVIEWED

    Source sequence(s)
    AC099731
  57. NM_001367693.1NP_001354622.1  SUN domain-containing protein 1 isoform ddd

    Status: REVIEWED

    Source sequence(s)
    AC099731
  58. NM_001367694.1NP_001354623.1  SUN domain-containing protein 1 isoform eee

    Status: REVIEWED

    Source sequence(s)
    AC099731
  59. NM_001367695.1NP_001354624.1  SUN domain-containing protein 1 isoform fff

    Status: REVIEWED

    Source sequence(s)
    AC099731
  60. NM_001367696.1NP_001354625.1  SUN domain-containing protein 1 isoform ggg

    Status: REVIEWED

    Source sequence(s)
    AC099731
  61. NM_001367697.1NP_001354626.1  SUN domain-containing protein 1 isoform hhh

    Status: REVIEWED

    Source sequence(s)
    AC099731
  62. NM_001367698.1NP_001354627.1  SUN domain-containing protein 1 isoform iii

    Status: REVIEWED

    Source sequence(s)
    AC099731
  63. NM_001367699.1NP_001354628.1  SUN domain-containing protein 1 isoform jjj

    Status: REVIEWED

    Source sequence(s)
    AC099731
  64. NM_001367700.1NP_001354629.1  SUN domain-containing protein 1 isoform kkk

    Status: REVIEWED

    Source sequence(s)
    AC099731
  65. NM_001367701.1NP_001354630.1  SUN domain-containing protein 1 isoform lll

    Status: REVIEWED

    Source sequence(s)
    AC099731
  66. NM_001367702.1NP_001354631.1  SUN domain-containing protein 1 isoform mmm

    Status: REVIEWED

    Source sequence(s)
    AC099731
  67. NM_001367703.1NP_001354632.1  SUN domain-containing protein 1 isoform nnn

    Status: REVIEWED

    Source sequence(s)
    AC099731
  68. NM_001367704.1NP_001354633.1  SUN domain-containing protein 1 isoform ooo

    Status: REVIEWED

    Source sequence(s)
    AC099731
  69. NM_001367705.1NP_001354634.1  SUN domain-containing protein 1 isoform ppp

    Status: REVIEWED

    Source sequence(s)
    AC099731
  70. NM_001367706.1NP_001354635.1  SUN domain-containing protein 1 isoform qqq

    Status: REVIEWED

    Source sequence(s)
    AC099731
  71. NM_001367708.1NP_001354637.1  SUN domain-containing protein 1 isoform sss

    Status: REVIEWED

    Source sequence(s)
    AC099731
  72. NM_025154.6NP_079430.3  SUN domain-containing protein 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an in-frame exon in the 5' portion of the coding region. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AC099731
    Consensus CDS
    CCDS43533.1
    UniProtKB/Swiss-Prot
    O94901
    Related
    ENSP00000374225.3, ENST00000389574.7
    Conserved Domains (3) summary
    pfam07738
    Location:565700
    Sad1_UNC; Sad1 / UNC-like C-terminal
    pfam09387
    Location:22208
    MRP; Mitochondrial RNA binding protein MRP
    pfam16043
    Location:356472
    DUF4795; Domain of unknown function (DUF4795)

RNA

  1. NR_160281.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099731
  2. NR_160282.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099731
    Related
    ENST00000413171.6
  3. NR_160283.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC099731

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    815557..874934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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